- Pleckstrin homology domain of phospholipase C-gamma1 directly binds to 68-kDa neurofilament light chain
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Kim SK, Choi JH, Suh PG, Chang JS
- KMID: 1094152
- Exp Mol Med.
- 2006 Jun;38(3):265-272.
Phosphoinositide-specific phospholipase C-gamma1 (PLC-gamma1) has two pleckstrin homology (PH) domains: an amino-terminal domain (PH1) and a split PH domain (PH2). Here, we show that overlay assay of bovine brain tubulin... -
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- The role of the alpha4 integrin-paxillin interaction in regulating leukocyte trafficking
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Rose DM
- KMID: 1094143
- Exp Mol Med.
- 2006 Jun;38(3):191-195.
The movement of leukocytes from the blood into peripheral tissues is a central feature of immune surveillance, but also contributes to the pathogenesis of inflammatory and autoimmune diseases. Integrins are... -
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- The role of tonicity responsive enhancer sites in the transcriptional regulation of human hsp70-2 in response to hypertonic stress
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Heo JI, Lee MS, Kim JH, Lee JS, Kim J, Park JB, Lee JY, Han JA, Kim JI
- KMID: 1094155
- Exp Mol Med.
- 2006 Jun;38(3):295-301.
The inducible 70 kDa heat shock proteins (Hsp70) in mice are encoded by two almost identical genes, hsp70.1 and hsp70.3. Studies have found that only hsp70.1 is induced by hypertonic... -
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- Delayed allograft rejection by the suppression of class II transactivator
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Kim TW, Choi YM, Seo JN, Kim JH, Suh YH, Chung DH, Jung KC, Oh KI
- KMID: 1094146
- Exp Mol Med.
- 2006 Jun;38(3):210-216.
We examined the effect of class II transactivator (CIITA) down-modulation on allograft rejection. To inhibit the function of CIITA, we constructed a series of CIITA mutants and found one exhibiting... -
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- Expression of hepatitis C virus nonstructural 4B in transgenic mice
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Wang AG, Moon HB, Kim JM, Hwang SB, Yu DY, Lee DS
- KMID: 1094149
- Exp Mol Med.
- 2006 Jun;38(3):241-246.
Hepatitis C virus (HCV) is a pathogen that is of great medical significance in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Although the HCV proteins have been intensively investigated... -
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- Analysis of the variations in IL-28RA gene and their association with allergic rhinitis
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Chae SC, Park YR, Li CS, Lee JH, Yang YS, Zhang Q, Kim KS, Chung HT
- KMID: 1094156
- Exp Mol Med.
- 2006 Jun;38(3):302-309.
IL-28RA is one of the important candidate genes for complex trait of genetic diseases, but there is no published information of the genetic variation in this gene. We scanned the... -
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- Antisurvivin oligonucleotides inhibit growth and induce apoptosis in human medullary thyroid carcinoma cells
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Du ZX, Zhang HY, Gao DX, Wang HQ, Li YJ, Liu GL
- KMID: 1094148
- Exp Mol Med.
- 2006 Jun;38(3):230-240.
Suvivin is a novel member of the inhibitor of apoptosis protein (IAP) family, which is known to be over-expressed in various carcinomas and associated with their biologically aggressive characteristics. The... -
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- An antioxidant modulates expression of receptor activator of NF-kappaB in asthma
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Lee KS, Park HS, Park SJ, Kim SR, Min KH, Jin SM, Li L, Lee YC
- KMID: 1094147
- Exp Mol Med.
- 2006 Jun;38(3):217-229.
Oxidative stress plays critical roles in airway inflammation that is usually accompanied by increased vascular permeability and plasma exudation. VEGF increases vascular permeability and leads to airway inflammation. In addition,... -
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- Role of p21CIP1 as a determinant of SC-560 response in human HCT116 colon carcinoma cells
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Lee E, Choi MK, Han IO, Lim SJ
- KMID: 1094159
- Exp Mol Med.
- 2006 Jun;38(3):325-331.
SC-560, a strucutral analogue of celecoxib, induces growth inhibition in a wide range of human cancer cells in a cyclooxygenase (COX)-independent manner. Since SC-560 suppresses the growth of cancer cells... -
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- Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1
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Kwak HB, Yang D, Ha H, Lee JH, Kim HN, Woo ER, Lee S, Kim HH, Lee ZH
- KMID: 1094151
- Exp Mol Med.
- 2006 Jun;38(3):256-264.
Bone is a dynamic tissue that is regulated by the activity of bone-resorbing osteoclasts and bone-forming osteoblasts. Excessive osteoclast formation causes diseases such as osteoporosis and rheumatoid arthritis. Natural substances... -
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- Characterization of a brain tumor cell line established from transgenic mice expressing the vasopressin SV-40 T antigen
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Kim SH, Kim MO, Lee SR, Kim KS, Lee TH, Lee HT, Ha JH, Kim TY, Ryoo ZY
- KMID: 1094144
- Exp Mol Med.
- 2006 Jun;38(3):196-202.
We previously reported that transgenic mice produced with a transgene consisting of the SV40 T antigen and vasopressin without the 3'-flanking region exhibit brain tumors and lymphoma. In this study,... -
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- Heterogeneous nuclear ribonuclear protein C is increased in the celecoxib-induced growth inhibition of human oral squamous cell carcinoma
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Lee EJ, Kim SH, Kwark YE, Kim J
- KMID: 1094145
- Exp Mol Med.
- 2006 Jun;38(3):203-209.
Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) that is a critical factor in carcinogenesis, but precise mechanism of its action remains to be elucidated. Here we evaluated the inhibitory... -
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- Association between excision repair cross-complementation group 1 polymorphism and clinical outcome of platinum-based chemotherapy in patients with epithelial ovarian cancer
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Kang S, Ju W, Kim JW, Park NH, Song YS, Kim SC, Park SY, Kang SB, Lee HP
- KMID: 1094158
- Exp Mol Med.
- 2006 Jun;38(3):320-324.
ERCC1 is a DNA repair gene and has been associated with resistance to DNA damaging agents. In this study we hypothesized that a polymorphism of ERCC1 Asn118Asn (C->T) might affect... -
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- Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas
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Cho YG, Kim CJ, Song JH, Rhie DJ, Park YK, Kim SY, Nam SW, Yoo NJ, Lee JY, Park WS
- KMID: 1094150
- Exp Mol Med.
- 2006 Jun;38(3):247-255.
The potassium channels are ubiquitous multisubunit membrane proteins, and potassium-dependent alterations in the membrane potential play an important role in the proliferation of many types of cells. This study analyzed... -
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- Two-signal blockade with anti-CD45RB and anti-CD154 monoclonal antibodies inhibits graft rejection via CD4-dependent mechanisms in allogeneic skin transplantation
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Kim EY, Lee EN, Lee J, Park HJ, Chang CY, Jung DY, Choi SY, Lee SK, Joh JW, Kim SJ
- KMID: 1094154
- Exp Mol Med.
- 2006 Jun;38(3):284-294.
Blockade of signal 1 or 2 for T-cell activation by the use of anti-CD45RB and anti-CD154 monoclonal antibodies (mAb) (two-signal blockade) has been proven effective in preventing or delaying graft... -
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- Cell type-specific upregulation of myristoylated alanine-rich C kinase substrate and protein kinase C-alpha, -beta I, -beta II, and -delta in microglia following kainic acid-induced seizures
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Eun SY, Kim EH, Kang KS, Kim HJ, Jo SA, Kim SJ, Jo SH, Kim SJ, Blackshear PJ, Kim J
- KMID: 1094157
- Exp Mol Med.
- 2006 Jun;38(3):310-319.
Myristoylated alanine-rich C kinase substrate (MARCKS) is a widely distributed protein kinase C (PKC) substrate and has been implicated in actin cytoskeletal rearrangement in response to extracellular stimuli. Although MARCKS... -
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- Tissue engineering of heart valves by recellularization of glutaraldehyde-fixed porcine valves using bone marrow-derived cells
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Kim SS, Lim SH, Cho SW, Gwak SJ, Hong YS, Chang BC, Park MH, Song KW, Choi CY, Kim BS
- KMID: 1094153
- Exp Mol Med.
- 2006 Jun;38(3):273-283.
To increase the biocompatibility and durability of glutaraldehyde (GA)-fixed valves, a biological coating with viable endothelial cells (ECs) has been proposed. However, stable EC layers have not been formed successfully... -
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