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Age-related decline in expression of calnexin

Choi BH, Kim JS

  • KMID: 1123772
  • Exp Mol Med.
  • 2004 Oct;36(5):499-503.
Aging is accompanied by the changes in the cells that decrease their capacity to respond to various forms of stress. Cells are known to respond to stresses through expression of...
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Involvement of mitogen-activated protein kinases and p21Waf1 in hydroxyurea-induced G1 arrest and senescence of McA-RH7777 rat hepatoma cell line

Hong SH, Hong BS, Kim DC, Rho MS, Park JI, Rha SH, Jun HS, Jeong JS

  • KMID: 1123771
  • Exp Mol Med.
  • 2004 Oct;36(5):493-498.
Hydroxyurea is commonly used to treat hematologic disorders and some type of solid tumors, but the mechanism for its therapeutic effect is not clearly known. In this study, we examined...
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Der f 2 activates phospholipase D in human T lymphocytes from Dermatophagoides farinae specific allergic individuals: Involvement of protein kinase C-alpha

Oh JW, Kim EY, Koo BS, Lee HB, Lee KS, Kim YS, Han JS

  • KMID: 1123770
  • Exp Mol Med.
  • 2004 Oct;36(5):486-492.
The major house-dust mite allergen, Der f 2, stimulates the phospholipase D (PLD) in T lymphocytes from Dermatophagoides farinae specific allergic individuals. PLD activity increased more than two-fold in T...
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Extracellular ATP is generated by ATP synthase complex in adipocyte lipid rafts

Kim BW, Choo HJ, Lee JW, Kim JH, Ko YG

  • KMID: 1123769
  • Exp Mol Med.
  • 2004 Oct;36(5):476-485.
Mitochondrial biogenesis is known to accompany adipogenesis to complement ATP and acetyl-CoA required for lipogenesis. Here, we demonstrated that mitochondrial proteins such as ATP synthase alpha and beta, and cytochrome...
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Transcriptional regulation of Zic3 by heterodimeric AP-1(c-Jun/c-Fos) during Xenopus development

Lee SY, Lee HS, Moon JS, Kim JI, Park JB, Lee JY, Park MJ, Kim J

  • KMID: 1123768
  • Exp Mol Med.
  • 2004 Oct;36(5):468-475.
The heterodimeric c-Jun/c-Fos, an activator protein-1 (AP-1) has been implicated in mesoderm induction (Dong et al., 1996; Kim et al., 1998) whereas the homodimer of c-Jun was reported to be...
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Protein kinase A mediates microglial activation induced by plasminogen and gangliosides

Min KJ, Yang MS, Jou I, Joe EH

  • KMID: 1123767
  • Exp Mol Med.
  • 2004 Oct;36(5):461-467.
In the injured brain, microglia is known to be activated and produce proinflammatory mediators such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS). We investigated...
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Phospholipase D activity is elevated in hepatitis C virus core protein-transformed NIH3T3 mouse fibroblast cells

Kim J, Choi BH, Jang KL, Min DS

  • KMID: 1123766
  • Exp Mol Med.
  • 2004 Oct;36(5):454-460.
Hepatitis C Virus (HCV) is associated with a severe liver disease and increased frequency in the development of hepatocellular carcinoma. Overexpression of HCV core protein is known to transform fibroblast...
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Involvement of Sox-4 in the cytochrome c-dependent AIF-independent apoptotic pathway in HeLa cells induced by delta12-prostaglandin J2

Kim BE, Lee JH, Kim HS, Kwon OJ, Jeong SW, Kim IK

  • KMID: 1123765
  • Exp Mol Med.
  • 2004 Oct;36(5):444-453.
delta12-Prostaglandin (PG) J2 is known to elicit an anti-neoplastic effects via apoptosis induction. Previous study showed delta12-PGJ2-induced apoptosis utilized caspase cascade through cytochrome c-dependent pathways in HeLa cells. In this...
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Activated natural killer cell-mediated immunity is required for the inhibition of tumor metastasis by dendritic cell vaccination

Kim A, Noh YW, Kim KD, Jang YS, Choe YK, Lim JS

  • KMID: 1123764
  • Exp Mol Med.
  • 2004 Oct;36(5):428-443.
Immunization with dendritic cells (DCs) pulsed with tumor antigen can activate tumor-specific cytotoxic T lymphocytes (CTL), which is responsible for tumor protection and regression. In this study, we examined whether...
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Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells

Lee WJ, Yoo HS, Suh PG, Lim JS, Oh S, Lee YM

  • KMID: 1123763
  • Exp Mol Med.
  • 2004 Oct;36(5):420-427.
FTY720, a synthetic sphingoid base analog, was examined as a new sphingosine kinase inhibitor, which converts endogenous sphingosine into its phosphate form. With 20 micrometer of FTY720, sphingosine accumulated in...
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Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells

Park HW, Song JY, Kim KS, Han Y, Kim CW, Yi SY, Yun YS

  • KMID: 1123762
  • Exp Mol Med.
  • 2004 Oct;36(5):411-419.
Ceramide generated from sphingomyelin in response to ionizing radiation has been implicated as a second messenger to induce cellular proapoptotic signals. Both ceramide and its metabolic inhibitor, N, N-dimethyl-D-erythro-sphingosine (DMS),...
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Evaluation of biological monitoring markers using genomic and proteomic analysis for automobile emission inspectors and waste incinerating workers exposed to polycyclic aromatic hydrocarbons or 2,3,7,8,-tetracholrodedibenzo-p-dioxins

Kim MK, Oh S, Lee JH, Im H, Ryu YM, Oh E, Lee J, Lee E, Sul D

  • KMID: 1123761
  • Exp Mol Med.
  • 2004 Oct;36(5):396-410.
In this study, we investigated the effects of PAHs and dioxin on mRNA and plasma protein expression using genomic and proteomic analysis for automobile emission inspectors and waste incineration workers....
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Early effect of Mycobacterium tuberculosis infection on Mac-1 and ICAM-1 expression on mouse peritoneal macrophages

Ghosh S, Saxena RK

  • KMID: 1123760
  • Exp Mol Med.
  • 2004 Oct;36(5):387-395.
Effect of M. tuberculosis infection was studied on the expression of intercellular adhesion molocule-1 (ICAM-1) and Mac-1 markers on murine peritoneal macrophages. Intraperitoneal administration of M. tuberculosis resulted in a...
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