- Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas
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Lee H
- KMID: 1093618
- Exp Mol Med.
- 2003 Oct;35(5):448-453.
Breast cancer susceptibility gene, BRCA2, is a tumor suppressor and individuals who inherit one defected copy of BRCA2 allele experience early onset breast cancer or ovarian cancer accompanied by the... -
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- Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: Involvement of RTP801 in amyloid beta-peptide toxicity
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Kim JR, Lee SR, Chung HJ, Kim S, Baek SH, Kim JH, Kim YS
- KMID: 1093613
- Exp Mol Med.
- 2003 Oct;35(5):403-411.
Amyloid beta-peptide (Abeta), a causative molecule in the pathogenesis of Alzheimer's disease and the main component of senile plaques, is known to be neurotoxic in vitro and in vivo. The... -
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- Chronic activation of CREB and p90RSK in human epileptic hippocampus
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Park SA, Kim TS, Choi KS, Park HJ, Heo K, Lee BI
- KMID: 1093608
- Exp Mol Med.
- 2003 Oct;35(5):365-370.
Mesial temporal lobe epilepsy (MTLE) is associated with severe neuronal death and reactive gliosis in hippocampus. However, the molecular mechanisms underlying these pathological changes remain unanswered. ERK has been reported... -
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- Real-time PCR analysis of the apoptosis related genes in ATRA treated APL t(15;17) patients
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Savli H, Sirma S, Nagy B, Aktan M, Dincol G, Ozbek U
- KMID: 1093619
- Exp Mol Med.
- 2003 Oct;35(5):454-459.
All-trans retinoic acid (ATRA) treatment of the acute promyelocytic leukemia (APL) have subsequently resulted in cell apoptosis, but the molecular mechanism of this effect remains elusive. In order to understand... -
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- Genomic organization and expression of parkin in Drosophila melanogaster
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Bae YJ, Park KS, Kang SJ
- KMID: 1093612
- Exp Mol Med.
- 2003 Oct;35(5):393-402.
We report here the isolation, characterization on genomic structure and expression of the D. melanogaster homolog of human parkin. The 2,122 bp parkin gene sequence contains six exons that form... -
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- B cells activated in the presence of Th1 cytokines inhibit osteoclastogenesis
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Choi Y, Kim JJ
- KMID: 1093611
- Exp Mol Med.
- 2003 Oct;35(5):385-392.
Host immune response has been considered as an important disease-modifying factor of periodontitis, however, which immune cell(s) or factor(s) are involved in the destruction of periodontium remains unclear. Previously, we... -
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- Biochemical characterizations reveal different properties between CDK4/cyclin D1 and CDK2/cyclin A
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Kim DM, Yang K, Yang BS
- KMID: 1093615
- Exp Mol Med.
- 2003 Oct;35(5):421-430.
CDK2 and CDK4 known promoter of cell cycling catalyze phosphorylation of RB protein. Enzyme specificity between two CDKs that work at a different cell cycle phase is not clearly understood.... -
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- Phagocytosis induces superoxide formation and apoptosis in macrophages
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Park JB
- KMID: 1093604
- Exp Mol Med.
- 2003 Oct;35(5):325-335.
Phagocytosis by inflammatory cells is an essential step and a part of innate immunity for protection against foreign pathogens, microorganism or dead cells. Phagocytosis, endocytotic events sequel to binding particle... -
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- Dexamethasone-induced differentiation of pancreatic AR42J cell involves p21(waf1/cip1)and MAP kinase pathway
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Eum WS, Li MZ, Sin GS, Choi SY, Park JB, Lee JY, Kwon HY
- KMID: 1093610
- Exp Mol Med.
- 2003 Oct;35(5):379-384.
Dexamethasone converts pluripotent pancreatic AR42J cells into exocrine cells expressing digestive enzymes. In order to address molecular mechanism of this differentiation, we have investigated the role of mitogen-activated protein (MAP)... -
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- Soluble glucocorticoid-induced TNF receptor (sGITR) induces inflammation in mice
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Shin HH, Kim SG, Lee MH, Suh JH, Kwon BS, Choi HS
- KMID: 1093607
- Exp Mol Med.
- 2003 Oct;35(5):358-364.
Glucocorticoid-induced TNF receptor (GITR) was a new member of the TNF/nerve growth factor receptor (TNFR/ NGFR) family and induced in murine T cells by dexamathasone. Recombinant soluble GITR (sGITR) induced... -
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- Grape extracts suppress the formation of preneoplastic foci and activity of fatty acid synthase in rat liver
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Kweon S, Kim Y, Choi H
- KMID: 1093609
- Exp Mol Med.
- 2003 Oct;35(5):371-378.
This study was conducted to examine the effects of dietary grape extracts on preneoplastic foci formation in rat hepatocarcinogenesis, and related hepatic enzymes. Male Sprague-Dawley rats were fed basal diet... -
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- CD99 type II is a determining factor for the differentiation of primitive neuroectodermal cells
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Lee EJ, Lee HG, Park SH, Choi EY, Park SH
- KMID: 1093617
- Exp Mol Med.
- 2003 Oct;35(5):438-447.
CD99 is a 32-kDa cell surface molecule present on thymocytes, peripheral T cells, many other hematopoietic stem cells and somatic cells were implicated in cell-cell adhesion and cell-activation phenomena. Two... -
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- NF-kappaB is involved in the TNF-alpha induced inhibition of the differentiation of 3T3-L1 cells by reducing PPARg expression
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Chae GN, Kwak SJ
- KMID: 1093616
- Exp Mol Med.
- 2003 Oct;35(5):431-437.
TNF-alpha, a trimeric cytokine, was known to inhibit differention of preadipocytes to adipocytes. In the present study, we investigated signal mediators working downstream of TNF-alpha using murine 3T3-L1 cells. TNF-alpha... -
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- Comparison of oligonucleotide-microarray and serial analysis of gene expression (SAGE) in transcript profiling analysis of megakaryocytes derived from CD34+ cells
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Kim HL
- KMID: 1093620
- Exp Mol Med.
- 2003 Oct;35(5):460-466.
For the comprehensive analysis of transcript expression, the array-based hybridization analysis and the serial analysis of gene expression (SAGE) are commonly used platforms. The SAGE is based on a high-throughput... -
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- High efficiency transduction of human VEGF(165)into human skeletal myoblasts: in vitro studies
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Ye L, Haider HK, Jiang S, Ge R, Law PK, Sim EK
- KMID: 1093614
- Exp Mol Med.
- 2003 Oct;35(5):412-420.
We report the transduction of human VEGF(165)gene into human myoblast and characterization of the transduced myoblasts for transduction and expression efficiency. Human myoblasts were assessed by immunostaining for desmin expression.... -
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- Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells
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Joung YH, Park JH, Park T, Lee CS, Kim OH, Ye SK, Yang UM, Lee KJ, Yang YM
- KMID: 1093606
- Exp Mol Med.
- 2003 Oct;35(5):350-357.
STATs (signal transducers and activators of transcription) are proteins with dual functions: signal transducers in the cytoplasm and transcriptional activators in the nucleus. STAT proteins act as transcription factors activated... -
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- Gene expression profiling of oxidative stress on atrial fibrillation in humans
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Kim YH, Lee JH, Lim DS, Shim WJ, Ro YM, Park GH, Becker KG, Cho-Chung , Kim MK
- KMID: 1093605
- Exp Mol Med.
- 2003 Oct;35(5):336-349.
Atrial Fibrillation (AF) is thought be caused by oxidative stress. Oxidative stress at the cellular level results from many factors, including exposure to alcohol, medications, cold, toxins or radiation. In... -
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