- Screening of Dihydropyrimidine Dehydrogenase Genetic Variants by Direct Sequencing in Different Ethnic Groups
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Shin JG, Cheong HS, Kim JY, Kim LH, Han CS, Kim JO, Kim HD, Kim YH, Chung MW, Han SY, Shin HD
- KMID: 1793015
- J Korean Med Sci.
- 2013 Aug;28(8):1129-1133.
- doi: 10.3346/jkms.2013.28.8.1129
Dihydropyrimidine dehydrogenase (DPYD) is an enzyme that regulates the rate-limiting step in pyrimidine metabolism, especially catabolism of fluorouracil, a chemotherapeutic agent for cancer. In order to determine the genetic distribution... -
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- PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis
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Fan JH, Xiang MQ, Li QL, Shi HT, Guo JJ
- KMID: 2411974
- Gut Liver.
- 2016 May;10(3):456-463.
- doi: 10.5009/gnl15261
BACKGROUND/AIMS: The recognition of a correlation between patatin-like phospholipase domain containing-protein 3 (PNPLA3) rs738409 (C>G) and the severity of liver steatosis or fibrosis in chronic hepatitis C (CHC) has not... -
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- Comprehensive Variant Screening of the UGT Gene Family
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Kim JY, Cheong HS, Park BL, Kim LH, Namgoong S, Kim JO, Kim HD, Kim YH, Chung MW, Han SY, Shin HD
- KMID: 1779911
- Yonsei Med J.
- 2014 Jan;55(1):232-239.
- doi: 10.3349/ymj.2014.55.1.232
PURPOSE: UGT1A1, UGT2B7, and UGT2B15 are well-known pharmacogenes that belong to the uridine diphosphate glucuronyltransferase gene family. For personalized drug treatment, it is important to study differences in the frequency... -
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- IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis
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Ke Z, Yuan L, Ma J, Zhang X, Guo Y, Xiong H
- KMID: 2163619
- Yonsei Med J.
- 2015 Sep;56(5):1274-1287.
- doi: 10.3349/ymj.2015.56.5.1274
PURPOSE: The association of interleukin-10 (IL-10) polymorphisms (-1082G/A, -819C/T, -592A/C) and interleukin-6 (IL-6) poly-morphisms (-174G/C) with tuberculosis (TB) risk has been widely reported. However, the results are controversial. To clarify... -
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- Association between Toll-Like Receptor 9-1237T/C Polymorphism and the Susceptibility of Inflammatory Bowel Diseases: A Meta-Analysis
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Shang J, Wang X, Wang W, Pan H, Liu S, Li L, Chen L, Xia B
- KMID: 2466365
- Yonsei Med J.
- 2016 Jan;57(1):153-164.
- doi: 10.3349/ymj.2016.57.1.153
PURPOSE: The -1237T/C polymorphism of the Toll-like receptor 9 (TLR9) gene has been implicated in the susceptibility of inflammatory bowel diseases (IBDs), but the results remain conflicting. We further investigated... -
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- Investigation of -308G>A and -1031T>C Polymorphisms in the TNFA Promoter Region in Polish Peptic Ulcer Patients
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Salagacka , Zebrowska , Jelen A, Mirowski M, Balcerczak E
- KMID: 2070080
- Gut Liver.
- 2014 Nov;8(6):632-636.
- doi: 10.5009/gnl13224
BACKGROUND/AIMS: Tumor necrosis factor alpha (TNF-alpha) encoded by TNFA is a key mediator in inflammation, a precursor condition for peptic ulceration. Promoter polymorphisms of TNFA that influence its transcriptional activity... -
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