- Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells
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Oh SY, Park KS, Kim AJ, Choi KY
- KMID: 1093594
- Exp Mol Med.
- 2002 Mar;34(1):27-31.
Activation of the extra cellular signal regulated kinase (ERK) pathway is involved in both proliferation and growth arrest of cells depending on intensity and duration of stimuli. In this study,... -
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- Spinal Gabapentin and Antinociception: Mechanisms of Action
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Yoon MH, Choi JI, Jeong SW
- KMID: 2157631
- J Korean Med Sci.
- 2003 Apr;18(2):255-261.
- doi: 10.3346/jkms.2003.18.2.255
Spinal gabapentin has been known to show the antinociceptive effect. Although several assumptions have been suggested, mechanisms of action of gabapentin have not been clearly established. The present study was... -
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- Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media
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Lee YS, Lan Tran H, Van Ta Q
- KMID: 1088601
- Exp Mol Med.
- 2009 Apr;41(4):259-268.
- doi: 10.3858/emm.2009.41.4.029
Matrix metalloproteinase-9 (MMP-9) secreted from macrophages plays an important role in tissue destruction and inflammation through degradation of matrix proteins and proteolytic activation of cytokines/chemokines. Whereas the MEK-ERK and PI3K-Akt... -
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- Protein kinase C modulates telomerase activity in human cervical cancer cells
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Kim YW, Hur SY, Kim TE, Lee JM, Namkoong S, Ki IK, Kim JW
- KMID: 938880
- Exp Mol Med.
- 2001 Sep;33(3):156-163.
Telomerase, a ribonucleoprotein reverse transcriptase that extends telomeres of eukaryotic chromosomes is repressed in normal somatic cells but is activated during development and neoplasia. The regulation mechanism of telomerase activity... -
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- Prologation of c-Jun N-Terminal Kinase is Associated with Cell Death Induced by Tumor Necrosis Factor Alpha in Human Chondrocytes
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Yoon HS, Kim HA
- KMID: 2157687
- J Korean Med Sci.
- 2004 Aug;19(4):567-573.
- doi: 10.3346/jkms.2004.19.4.567
The aim of this study was to elucidate the role of JNK signaling pathway involved in tumor necrosis factor-alpha (TNF-alpha)-induced death of chondrocytes. Primary chondrocyte cultures were obtained from human... -
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- The Effects of Antioxidants and Nitric Oxide Modulators on Hepatic Ischemic-Reperfusion Injury in Rats
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Rhee JE, Jung SE, Shin SD, Suh GJ, Noh DY, Youn YK, Oh SK, Choe KJ
- KMID: 1109759
- J Korean Med Sci.
- 2002 Aug;17(4):502-506.
- doi: 10.3346/jkms.2002.17.4.502
Ischemic-reperfusion injury (IRI) is thought to be caused by oxygen radicals. Nitric oxide (NO) also has been thought to play a key role in IRI. This experiment was designed to... -
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- Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract
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Kim SE, Thuy TT, Lee JH, Ro JY, Bae YA, Kong Y, Ahn JY, Lee DS, Oh YM, Lee SD, Lee YS
- KMID: 1088603
- Exp Mol Med.
- 2009 Apr;41(4):277-287.
- doi: 10.3858/emm.2009.41.4.031
Matrix metalloproteinase-9 (MMP-9) may play an important role in emphysematous change in chronic obstructive pulmonary disease (COPD), one of the leading causes of mortality and morbidity worldwide. We previously reported... -
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- Expression of cyclin dependent kinase inhibitor p21WAF1 alone and in combination with p27KIP1 shows prognostic value in gastric carcinoma
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Jang SJ, Ahn MJ, Paik SS, Kong G, Keum JS, Park YW, Lee JD
- KMID: 1038163
- J Korean Med Sci.
- 1998 Aug;13(4):369-376.
- doi: 10.3346/jkms.1998.13.4.369
Evidence suggests that multiple molecular events, including alteration of cell cycle regulators are involved in the development and progression of gastric carcinoma. Recently, it has been reported that the... -
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- Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat
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Kang JW, Kim TW, La JH, Sung TS, Kim HJ, Kwon YB, Kim JY, Yang IS
- KMID: 1099831
- J Vet Sci.
- 2004 Sep;5(3):189-195.
The effect of electroacupuncture (EA) on experimental colitis was investigated in Sprague-Dawley rats. Colitis was induced by intracolonic instillation of 4% acetic acid. EA (2 Hz, 0.05 ms, 2 V... -
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- Genotype-Phenotype correlation of SMN locus genes in spinal muscular atrophy patients from India
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Kesari A, Idris MM, Chandak GR, Mittal B
- KMID: 1056225
- Exp Mol Med.
- 2005 Jun;37(3):147-154.
Spinal muscular atrophy has been classified into four groups based on the age of onset and clinical severity of the disease. Homozygous deletion in SMN1 gene causes the disease but... -
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