- The role of adiponectin in the production of IL-6, IL-8, VEGF and MMPs in human endothelial cells and osteoblasts: implications for arthritic joints
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Lee YA, Ji HI, Lee SH, Hong SJ, Yang HI, Chul Yoo M, Kim KS
- KMID: 2155337
- Exp Mol Med.
- 2014 Jan;46(1):e72.
- doi: 10.1038/emm.2013.141
This study was performed to evaluate the contribution of adiponectin to the production of interleukin (IL)-6, IL-8, vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-1 and MMP-13 in human endothelial... -
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- KR-31831, a new synthetic anti-ischemic agent, inhibits in vivo and in vitro angiogenesis
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Yi EY, Park SY, Song HS, Son MJ, Yi KY, Yoo SE, Kim YJ
- KMID: 1098084
- Exp Mol Med.
- 2006 Oct;38(5):502-508.
Angiogenesis is considered to be an integral process to the growth and spread of solid tumors. Anti-angiogenesis therapy recently has been found to be one of the most promising anti-cancer... -
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- Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase
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Chung BH, Kim S, Kim JD, Lee JJ, Baek YY, Jeoung D, Lee H, Choe J, Ha KS, Won MH, Kwon YG, Kim YM
- KMID: 1245262
- Exp Mol Med.
- 2012 Mar;44(3):191-201.
- doi: 10.3858/emm.2012.44.3.014
Nitric oxide (NO) produced by endothelial NO synthase (eNOS) plays an important role in vascular functions, including vasorelaxation. We here investigated the pharmacological effect of the natural product syringaresinol on... -
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- Morphine Attenuates Endothelial Cell Adhesion Molecules Induced by the Supernatant of LPS-Stimulated Colon Cancer Cells
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Min TJ, Park SH, Ji YH, Lee YS, Kim TW, Kim JH, Kim WY, Park YC
- KMID: 1785959
- J Korean Med Sci.
- 2011 Jun;26(6):747-752.
- doi: 10.3346/jkms.2011.26.6.747
A large reservoir of bacterial lipopolysaccharide (LPS) is available in the colon and this could promote colon cancer metastasis by enhancing tumor cell adhesion, intravasation, and extravasation. Furthermore, adhesion molecules... -
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- Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity
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Woo A, Min B, Ryoo S
- KMID: 1104212
- Exp Mol Med.
- 2010 Jul;42(7):524-532.
- doi: 10.3858/emm.2010.42.7.053
Arginase competitively inhibits nitric oxide synthase (NOS) via use of the common substrate L-arginine. Arginase II has recently reported as a novel therapeutic target for the treatment of cardiovascular diseases... -
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- Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro
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Hur JM, Shim JS, Jung HJ, Kwon HJ
- KMID: 755752
- Exp Mol Med.
- 2005 Apr;37(2):133-137.
In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of... -
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- KR-31543 reduces the production of proinflammatory molecules in human endothelial cells and monocytes and attenuates atherosclerosis in mouse model
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Choi JH, Yoo JY, Kim SO, Yoo SE, Oh GT
- KMID: 1402317
- Exp Mol Med.
- 2012 Dec;44(12):733-739.
KR-31543, (2S, 3R, 4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro-2-dimethyoxymethyl-3-hydroxy-2-methyl-2H-1-benz opyran is a new neuroprotective agent for ischemia-reperfusion damage. It has also been reported that KR-31543 has protective effects on lipid peroxidation and H2O2-induced reactive... -
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- Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1
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Kang JH, Kim SA, Chang SY, Hong S, Hong KJ
- KMID: 1047092
- Exp Mol Med.
- 2007 Jun;39(3):402-411.
Expression of thrombospondin-1 (TSP-1), which is a known inhibitor of tumor growth and angiogenesis, is reciprocally regulated by positive regulators, such as VEGF. Additionally, trichostatin A (TSA) suppresses tumor progression... -
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- Expression and Regulation of Latent TGF-beta Binding Protein-1 Transcripts and Their Splice Variants in Human Glomerular Endothelial Cells
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Kwak JH, Woo JS, Shin K, Kim HJ, Jeong HS, Han DC, Kim SI, Park CS
- KMID: 1712745
- J Korean Med Sci.
- 2005 Aug;20(4):628-635.
- doi: 10.3346/jkms.2005.20.4.628
Latent transforming growth factor (TGF)-beta-binding protein (LTBP) is required for the assembly, secretion, matrix association, and activation of latent TGF-beta complex. To elucidate the cell specific expression of the genes... -
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- Cinnamyl alcohol attenuates vasoconstriction by activation of K+ channels via NO-cGMP-protein kinase G pathway and inhibition of Rho-kinase
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Kang YH, Yang IJ, Morgan KG, Shin HM
- KMID: 1402319
- Exp Mol Med.
- 2012 Dec;44(12):749-755.
Cinnamyl alcohol (CAL) is known as an antipyretic, and a recent study showed its vasodilatory activity without explaining the mechanism. Here we demonstrate the vasodilatory effect and the mechanism of... -
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- Natural compounds, fraxin and chemicals structurally related to fraxin protect cells from oxidative stress
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Whang WK, Park HS, Ham I, Oh M, Namkoong H, Kim HK, Hwang DW, Hur SY, Kim TE, Park YG, Kim JR, Kim JW
- KMID: 1089453
- Exp Mol Med.
- 2005 Oct;37(5):436-446.
Coumarins comprise a group of natural phenolic compounds found in a variety of plant sources. In view of the established low toxicity, relative cheapness, presence in the diet and occurrence... -
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- Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells
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Lee WJ, Yoo HS, Suh PG, Lim JS, Oh S, Lee YM
- KMID: 1123763
- Exp Mol Med.
- 2004 Oct;36(5):420-427.
FTY720, a synthetic sphingoid base analog, was examined as a new sphingosine kinase inhibitor, which converts endogenous sphingosine into its phosphate form. With 20 micrometer of FTY720, sphingosine accumulated in... -
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