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Inevitability of Balance Restoration

Oh MS

Prolonged imbalance between input and output of any element in a living organism is incompatible with life. The duration of imbalance varies, but eventually balance is achieved. This rule applies...
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A Practical Approach to Genetic Hypokalemia

Lin SH, Yang SS, Chau T

Mutations in genes encoding ion channels, transporters, exchangers, and pumps in human tissues have been increasingly reported to cause hypokalemia. Assessment of history and blood pressure as well as the...
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Uncoventional Views on Certain Aspects of Toxin-Induced Metabolic Acidosis

Oh MS

This discussion will highlight the following 9 specific points that related to metabolic acidosis caused by various toxins. The current recommendation suggests that alcohol dehydrogenase inhibitor fomepizole is preferred to...
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Is There Escape from Renal Actions of Vasopressin in Rats with a Hyponatremia for Greater than 48 Hours?

Cheema-Dhadli S, Chong CK, Alazmi M, Kamel KS, Halperin M

Escape from the renal actions of vasopressin is said to occur in rats with chronic hyponatremia. Our objective was to provide specific evidence to test this hypothesis. Hence the osmolality...
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Molecular Approach for Distal Renal Tubular Acidosis Associated AE1 Mutations

Vasuvattakul S

The molecular approaches to distal renal tubular acidosis (dRTA) associated AE1 mutations lead us to understand the genetic and pathophysiological aspects of the acidification defects. An unanticipated high value of...
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Importance of Residual Water Permeability on the Excretion of Water during Water Diuresis in Rats

Cheema-Dhadli S, Chong CK, Kim N, Kamel KS, Halperin M

When the concentration of sodium (Na+) in arterial plasma (P(Na)) declines sufficiently to inhibit the release of vasopressin, water will be excreted promptly when the vast majority of aquaporin 2...
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Thiazide-Induced Hyponatremia

Hwang KS, Kim GH

The importance of thiazide-induced hyponatremia (TIH) is reemerging because thiazide diuretic prescription seems to be increasing after the guidelines recommending thiazides as first-line treatment of essential hypertension have been introduced....
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