- Down-Regulation of TGF-β Expression Sensitizes the Resistance of Hepatocellular Carcinoma Cells to Sorafenib
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Kang D, Han Z, Oh GH, Joo Y, Choi HJ, Song JJ
- KMID: 2418924
- Yonsei Med J.
- 2017 Sep;58(5):899-909.
- doi: 10.3349/ymj.2017.58.5.899
PURPOSE: Sorafenib, a multikinase inhibitor, is the standard therapy for patients with advanced-stage hepatocellular carcinoma (HCC). However, resistance develops to the treatment, therefore, we tried to unravel the underlying mechanism... -
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- Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells
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Kim DS, Na YJ, Kang MH, Yoon SY, Choi CW
- KMID: 2373811
- Korean J Intern Med.
- 2016 Mar;31(2):357-366.
- doi: 10.3904/kjim.2015.024
BACKGROUND/AIMS: The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed,... -
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- Expression of Heat Shock Protein 70 Modulates the Chemoresponsiveness of Pancreatic Cancer
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Hyun JJ, Lee HS, Keum B, Seo YS, Jeen YT, Chun HJ, Um SH, Kim CD
- KMID: 1712336
- Gut Liver.
- 2013 Nov;7(6):739-746.
BACKGROUND/AIMS: Heat shock protein (HSP) 70 is constitutively overexpressed in pancreatic cancer cells (PCCs) and appears to confer protection against chemotherapeutics. We investigated whether modulating HSP 70 increases chemoresponsiveness to... -
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- Pseudomonas aeruginosa Exotoxin A Reduces Chemoresistance of Oral Squamous Carcinoma Cell via Inhibition of Heat Shock Proteins 70 (HSP70)
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Park SR, Lee KD, Kim UK, Gil YG, Oh KS, Park BS, Kim GC
- KMID: 1071422
- Yonsei Med J.
- 2010 Sep;51(5):708-716.
- doi: 10.3349/ymj.2010.51.5.708
PURPOSE: Oral squamous carcinoma (OSCC) cells exhibit resistance to chemotherapeutic agent-mediated apoptosis in the late stage of malignancy. Increased levels of heat shock proteins 70 (HSP70) in cancer cells are... -
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