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Preparation of Drug Eluting Natural Composite Scaffold Using Response Surface Methodology and Artificial Neural Network Approach

Shera SS, Sahu S, Banik RM

Silk fibroin/xanthan composite was investigated as a suitable biomedical material for controlled drug delivery, and blending ratios of silk fibroin and xanthan were optimized by response surface methodology (RSM) and...
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Absorption Study of Genistein Using Solid Lipid Microparticles and Nanoparticles: Control of Oral Bioavailability by Particle Sizes

Kim JT, Barua S, Kim H, Hong SC, Yoo SY, Jeon H, Cho Y, Gil S, Oh K, Lee J

In this study, the effect of particle size of genistein-loaded solid lipid particulate systems on drug dissolution behavior and oral bioavailability was investigated. Genistein-loaded solid lipid microparticles and nanoparticles were...
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Effect of Drug Carrier Melting Points on Drug Release of Dexamethasone-Loaded Microspheres

Park JH, Kwon DY, Heo JY, Park SH, Park JY, Lee B, Kim JH, Kim MS

Here, we examined the effect of melting point of drug carriers on drug release of dexamethasone (Dex)-loaded microspheres. We prepared poly(L-lactide-ran-ε-caprolactone) (PLC) copolymers with varying compositions of poly(εcaprolactone) (PCL) and...
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The Control of Drug Release and Vascular Endothelialization after Hyaluronic Acid-Coated Paclitaxel Multi-Layer Coating Stent Implantation in Porcine Coronary Restenosis Model

Bae IH, Jeong MH, Kim JH, Park YH, Lim KS, Park DS, Shim JW, Kim JH, Ahn Y, Hong YJ, Sim DS

BACKGROUND AND OBJECTIVES: Hyaluronic acid (HA) is highly biocompatible with cells and the extracellular matrix. In contrast to degradation products of a synthetic polymer, degradation products of HA do not...
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Bioresorbable Vascular Scaffold Korean Expert Panel Report

Ahn JM, Park DW, Hong SJ, Ahn YK, Hahn JY, Kim WJ, Hong SJ, Nam CW, Kang DY, Lee SY, Chun WJ, Heo JH, Cho DK, Kim JW, Her SH, Kim SW, Yoo SY, Hong MK, Tahk SJ, Kim KS, Kim MH, Jang Y, Park SJ

Bioresorbable vascular scaffold (BRS) is an innovative device that provides structural support and drug release to prevent early recoil or restenosis, and then degrades into nontoxic compounds to avoid late...
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Poloxamer 407 Hydrogels for Intravesical Instillation to Mouse Bladder: Gel-Forming Capacity and Retention Performance

Kim SH, Kim SR, Yoon HY, Chang IH, Whang YM, Cho MJ, Kim MJ, Kim SY, Lee SJ, Choi YW

PURPOSE: Poloxamer 407 (P407) thermo-sensitive hydrogel formulations were developed to enhance the retention time in the urinary bladder after intravesical instillation. MATERIALS AND METHODS: P407 hydrogels (P407Gels) containing 0.2 w/w% fluorescein...
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