- Pharmacogenomics in Drug Discovery and Development
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Ahn C
- KMID: 2166254
- Genomics Inform.
- 2007 Jun;5(2):41-45.
Pharmacogenomics is the study that examines how genetic variations affect the ways in which people respond to drugs. The ways people respond to drugs are complex traits that are influenced... -
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- Intercellular Lipid Mediators and GPCR Drug Discovery
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Im DS
- KMID: 2170658
- Biomol Ther.
- 2013 Nov;21(6):411-422.
G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets.... -
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- Genetically Engineered Mouse Models for Drug Development and Preclinical Trials
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Lee H
- KMID: 2170618
- Biomol Ther.
- 2014 Jul;22(4):267-274.
Drug development and preclinical trials are challenging processes and more than 80% to 90% of drug candidates fail to gain approval from the United States Food and Drug Administration. Predictive... -
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- Natural radioprotectors and their impact on cancer drug discovery
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Kuruba V, Gollapalli P
- KMID: 2434315
- Radiat Oncol J.
- 2018 Dec;36(4):265-275.
- doi: 10.3857/roj.2018.00381
Cancer is a complex multifaceted illness that affects different patients in discrete ways. For a number of cancers the use of chemotherapy has become standard practice. Chemotherapy is a use... -
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- Natural Product-Derived Drugs for the Treatment of Inflammatory Bowel Diseases
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Joo YE
- KMID: 2284894
- Intest Res.
- 2014 Apr;12(2):103-109.
- doi: 10.5217/ir.2014.12.2.103
Natural products have been used as drugs for millennia, and the therapeutic potential of natural products has been studied for more than a century. Since the mid-1880s, approximately 60% of... -
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- Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery
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Park SJ, Im DS
- KMID: 2367621
- Biomol Ther.
- 2017 Jan;25(1):80-90.
- doi: 10.4062/biomolther.2016.160
Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G... -
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- Evaluation of Advanced Structure-Based Virtual Screening Methods for Computer-Aided Drug Discovery
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Lee HS, Choi JW, Yoon SJ
- KMID: 2166251
- Genomics Inform.
- 2007 Mar;5(1):24-29.
Computational virtual screening has become an essential platform of drug discovery for the efficient identification of active candidates. Moleculardocking, a key technology of receptor-centric virtual screening, is commonly used to... -
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- New Molecules in Babesia gibsoni and Their Application for Diagnosis, Vaccine Development, and Drug Discovery
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Goo YK, Xuan X
- KMID: 1792195
- Korean J Parasitol.
- 2014 Aug;52(4):345-353.
- doi: 10.3347/kjp.2014.52.4.345
Babesia gibsoni is an intraerythrocytic apicomplexan parasite that causes piroplasmosis in dogs. B. gibsoni infection is characterized clinically by fever, regenerative anemia, splenomegaly, and sometimes death. Since no vaccine is... -
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- MicroSPECT and MicroPET Imaging of Small Animals for Drug Development
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Jang BS
- KMID: 2317809
- Toxicol Res.
- 2013 Mar;29(1):1-6.
The process of drug discovery and development requires substantial resources and time. The drug industry has tried to reduce costs by conducting appropriate animal studies together with molecular biological and... -
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- Ubiquitin Ligases in Cholesterol Metabolism
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Jiang W, Song BL
- KMID: 2280686
- Diabetes Metab J.
- 2014 Jun;38(3):171-180.
- doi: 10.4093/dmj.2014.38.3.171
To maintain cholesterol homeostasis, the processes of cholesterol metabolism are regulated at multiple levels including transcription, translation, and enzymatic activity. Recently, the regulation of protein stability of some key players... -
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- Dual Inhibitors Against Topoisomerases and Histone Deacetylases
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Seo YH
- KMID: 2171332
- J Cancer Prev.
- 2015 Jun;20(2):85-91.
- doi: 10.15430/JCP.2015.20.2.85
Topoisomerases and histone deacetylases (HDACs) are considered as important therapeutic targets for a wide range of cancers, due to their association with the initiation, proliferation and survival of cancer cells.... -
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- Basic Concept of Gene Microarray
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Hwang SY
- KMID: 2202800
- J Korean Soc Biol Psychiatry.
- 2001 Nov;8(2):203-207.
The genome sequencing project has generated and will continue to generate enormous amounts of sequence data including 5 eukaryotic and about 60 prokaryotic genomes. Given this ever-increasing amounts of sequence... -
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- Data Mining for High Dimensional Data in Drug Discovery and Development
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Lee KR, Park DC, Lin X, Eslava S
- KMID: 2053068
- Genomics Inform.
- 2003 Dec;1(2):65-74.
Data mining differs primarily from traditional data analysis on an important dimension, namely the scale of the data. That is the reason why not only statistical but also computer science... -
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- Modeling of Human Genetic Diseases Via Cellular Reprogramming
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Kang MY, Suh JH, Han YM
- KMID: 1428896
- J Genet Med.
- 2012 Dec;9(2):67-72.
- doi: 10.5734/JGM.2012.9.2.67
The generation of induced pluripotent stem cells (iPSCs) derived from patients' somatic cells provides a new paradigm for studying human genetic diseases. Human iPSCs which have similar properties of human... -
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- Diagnosing Diabetic Neuropathy: Something Old, Something New
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Petropoulos IN, Ponirakis , Khan A, Almuhannadi H, Gad H, Malik RA
- KMID: 2418714
- Diabetes Metab J.
- 2018 Aug;42(4):255-269.
- doi: 10.4093/dmj.2018.0056
There are potentially many ways of assessing diabetic peripheral neuropathy (DPN). However, they do not fulfill U.S. Food and Drug Administration (FDA) requirements in relation to their capacity to assess... -
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- Emerging strategies for the treatment of pulmonary tuberculosis: promise and limitations?
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Yew WW, Koh WJ
- KMID: 2373768
- Korean J Intern Med.
- 2016 Jan;31(1):15-29.
- doi: 10.3904/kjim.2016.31.1.15
A worsening scenario of drug-resistant tuberculosis has increased the need for new treatment strategies to tackle this worldwide emergency. There is a pressing need to simplify and shorten the current... -
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- Mining the Proteome of Fusobacterium nucleatum subsp. nucleatum ATCC 25586 for Potential Therapeutics Discovery: An In Silico Approach
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Habib AM, Islam MS, Sohel M, Mazumder M, Sikder MO, Shahik SM
- KMID: 2366444
- Genomics Inform.
- 2016 Dec;14(4):255-264.
- doi: 10.5808/GI.2016.14.4.255
The plethora of genome sequence information of bacteria in recent times has ushered in many novel strategies for antibacterial drug discovery and facilitated medical science to take up the challenge... -
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- Animal Models of Dementia
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Choi DH, Lee J
- KMID: 1445605
- Brain Neurorehabil.
- 2011 Mar;4(1):21-29.
- doi: 10.12786/bn.2011.4.1.21
The discovery of new therapies for neurological disorders is especially predicated on the use of animal models both to identify new therapeutic targets and to carry out preclinical drug trials.... -
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- PET-Based Molecular Nuclear Neuro-Imaging
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Kim JH
- KMID: 2078808
- Korean J Nucl Med.
- 2004 Apr;38(2):161-170.
Molecular Nuclear Neuro - Imaging in "CNS" drug discovery and development can be divided into four categories that are clearly inter-related. (1) Neuroreceptor mapping to examine the involvement of specific... -
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- The Role of medical doctor in the era of artificial intelligence
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Seo JB
- KMID: 2441063
- J Korean Med Assoc.
- 2019 Mar;62(3):136-139.
- doi: 10.5124/jkma.2019.62.3.136
Recent advances in new technologies such as artificial intelligence, big data, and virtual reality have led to significant innovations in various industries. Artificial intelligence, particularly in applications using deep learning... -
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