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Older Adults with Diabetes in Korea: Latest Clinical and Epidemiologic Trends

Kim K, Kim B, Lee K, Ahn YB, Ko SH, Choi SH, Han K, Yun JS, on Behalf of the Committee of Public Relation of the Korean Diabetes Association

Background: Diabetes in older adults is becoming a significant public burden to South Korea. However, a comprehensive understanding of epidemiologic trends and the detailed clinical characteristics of older adults with...
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Effects of Pancreatitis and Type 2 Diabetes Mellitus on the Development of Pancreatic Cancer: A Nationwide Nested Case-Control Study

Kim Ye, Yu MH, Nam CM, Kang ES

Background: Despite diabetes mellitus (DM) and pancreatitis being known risk factors for pancreatic cancer, patients with these conditions are not included in pancreatic cancer screening due to the low incidence...
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Exon Sequencing of HNF1β in Chinese Patients with Early-Onset Diabetes

Gong S, Lian H, Li Y, Cai X, Liu W, Luo Y, Li M, Zhang Sm, Zhang R, Zhou L, Zhu Y, Ren Q, Zhang X, Chen J, Wu J, Zhou X, Wang X, Han X, Ji L

Background: Maturity-onset diabetes of the young (MODY) due to variants of hepatocyte nuclear factor 1-beta (HNF1β) (MODY5) has not been well studied in the Chinese population. This study aimed to...
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Do Time-Dependent Repeated Measures of Anthropometric and Body Composition Indices Improve the Prediction of Incident Diabetes in the Cohort Study? Findings from a Community-Based Korean Genome and Epidemiology Study

Lee HA, Park H, Park B

Background: Cumulative evidence consistently shows that anthropometric and body composition measurements are strongly linked to the risk of incident diabetes, typically based on baseline measurements. This study aims to assess...
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Efficacy and Safety of Automated Insulin Delivery Systems in Patients with Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Fan W, Deng C, Xu R, Liu Z, Leslie RD, Zhou Z, Li X

Background: Automated insulin delivery (AID) systems studies are upsurging, half of which were published in the last 5 years. We aimed to evaluate the efficacy and safety of AID systems...
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Kidney Gastrin/CCKBR Attenuates Type 2 Diabetes Mellitus by Inhibiting SGLT2-Mediated Glucose Reabsorption through Erk/NF-κB Signaling Pathway

Zhang X, Zhang Y, Shi Y, Shi D, Niu M, Liu X, Liu X, Yang Z, Wu X

Background: Both sodium-glucose cotransporters (SGLTs) and Na+/H+ exchangers (NHEs) rely on a favorable Na-electrochemical gradient. Gastrin, through the cholecystokinin B receptor (CCKBR), can induce natriuresis and diuresis by inhibiting renal...
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Does 10-Year Atherosclerotic Cardiovascular Disease Risk Predict Incident Diabetic Nephropathy and Retinopathy in Patients with Type 2 Diabetes Mellitus? Results from Two Prospective Cohort Studies in Southern China

Chen J, Li YT, Niu Z, He Z, Xie YJ, Hernandez J, Huang W, Wang HH, on Behalf of the Guangzhou Diabetic Eye Study Group

Background: Diabetic macrovascular and microvascular complications often coexist and may share similar risk factors and pathological pathways. We aimed to investigate whether 10-year atherosclerotic cardiovascular disease (ASCVD) risk, which is...
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Rbbp6-Mediated Bmal1 Ubiquitination Inhibits YAP1 Signaling Pathway to Promote Ferroptosis in Diabetes-Induced Testicular Damage

Tian Y, Zhu Z, Qiao J, Liu B, Xiao Y

Background: Diabetes-induced testicular damage (DITD) is a common complication of diabetes. We investigated underlying mechanism of retinoblastoma-binding protein 6 (Rbbp6)-mediated brain and muscle ARNT-like 1 (Bmal1) ubiquitination in modulating ferroptosis...
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Study Design and Protocol for a Randomized Controlled Trial of Enavogliflozin to Evaluate Cardiorenal Outcomes in Type 2 Diabetes (ENVELOP)

Kim NH, Lim S, Jeong IK, Rhee EJ, Moon JS, Ryu OH, Kwon HS, Won JC, Kim SS, Kim SY, Ku BJ, Jin HY, Kim SG, Cha BS, on Behalf of Investigators of ENVELOP Study

Background: The novel sodium-glucose cotransporter-2 (SGLT2) inhibitor enavogliflozin effectively lowers glycosylated hemoglobin levels and body weights without the increased risk of serious adverse events; however, the long-term clinical benefits of...
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To Determine the Risk-Based Screening Interval for Diabetic Retinopathy: Development and Validation of Risk Algorithm from a Retrospective Cohort Study

Lian J, So C, McGhee SM, Thach Tq, Lam CLK, Fung CSC, Kwong ASK, Chan JCH

Background: The optimal screening interval for diabetic retinopathy (DR) remains controversial. This study aimed to develop a risk algorithm to predict the individual risk of referable sight-threatening diabetic retinopathy (STDR)...
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Prevalence, Incidence, and Metabolic Characteristics of Young Adults with Type 2 Diabetes Mellitus in South Korea (2010–2020)

Kim JY, Lee J, Moon JH, Park SE, Ko SH, Choi SH, Kim NH

Background: This study aimed to examine trends in the prevalence, incidence, metabolic characteristics, and management of type 2 diabetes mellitus (T2DM) among young adults in South Korea. Methods: Young adults with...
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Impact of Meal Frequency on Insulin Resistance in Middle-Aged and Older Adults: A Prospective Cohort Study

Ryu HE, Lee JH, Park B, Heo SJ, Kwon YJ

Background: Insulin resistance (IR) is central to metabolic disorders and significantly influenced by diet. Studies on meal frequency (MF) and metabolic indicators have shown mixed results. This study explores the...
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MondoA Is Required for Normal Myogenesis and Regulation of the Skeletal Muscle Glycogen Content in Mice

Ran H, Lu Y, Zhang Q, Hu Q, Zhao J, Wang K, Tong X, Su Q

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Glucagon-Like Peptide-1 Receptor Agonists: What’s the Optimizing Policies for Obesity-Related Metabolic Diseases?

Park TS

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Beyond Body Mass Index: New Criteria for a Holistic Approach to Clinical Obesity

Sung K, Lee SH, Lim S

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Comparison of SPISE and METS-IR and Other Markers to Predict Insulin Resistance and Elevated Liver Transaminases in Children and Adolescents

Song K, Lee E, Lee HS, Lee H, Lee JW, Chae HW, Kwon YJ

Background: Studies on predictive markers of insulin resistance (IR) and elevated liver transaminases in children and adolescents are limited. We evaluated the predictive capabilities of the single-point insulin sensitivity estimator...
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