- Properties of Hepatitis B Virus Associated DNA Polymerase
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Oh SH, Park YH
- KMID: 1729535
- Yonsei Med J.
- 1985 Dec;26(2):175-183.
- doi: 10.3349/ymj.1985.26.2.175
The nature of hepatitis B virus (HBV) particle associated DNA polymerase was studied in relation to various enzyme inhibitors including antiviral agents. HBV DNA polymerase required high concentration of MgCl2(>... -
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- The Mechanism of White and Brown Adipocyte Differentiation
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Nakagami H
- KMID: 2280709
- Diabetes Metab J.
- 2013 Apr;37(2):85-90.
- doi: 10.4093/dmj.2013.37.2.85
Obesity gives vent to many diseases such as type 2 diabetes, hypertension, and hyperlipidemia, being considered as the main causes of mortality and morbidity worldwide. The pathogenesis and pathophysiology of... -
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- Oral Bisphosphonates Induced Osteonecrosis of the Mandible : a Case Report
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Son HJ, Jang HY, Keum YS, Lee JY, Kim HC, Lee SC
- KMID: 2328434
- J Korean Assoc Oral Maxillofac Surg.
- 2009 Apr;35(2):106-111.
Bisphosphonates have been approved for Paget's disease, cancer - related hypercalcemia, bone involvement in multiple myeloma or solid tumors and osteoporosis. Although, underlying pathophysiological mechanisms remain unclear, it seems that bisphosphonates... -
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- Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations
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Kim JH, Jung YK, Joo MK, Kim JH, Yim HJ, Park JJ, Kim JS, Bak YT, Yeon JE, Byun KS
- KMID: 1779257
- J Korean Med Sci.
- 2010 Feb;25(2):257-264.
- doi: 10.3346/jkms.2010.25.2.257
The hepatitis B virus (HBV) polymerase gene has overlapping reading frames with surface genes, which allows to alter the amino acid codon of the surface genes. In adefovir (ADV) treated... -
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- Long-Term Outcomes and Dynamics of Mutants Associated with Lamivudine-Adefovir Rescue Therapy in Patients with Lamivudine-Resistant Chronic Hepatitis B
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Kim J, Lee SH, Kim HS, Choi K, Jeong SW, Kim SG, Jang JY, Kim YS, Kim BS
- KMID: 2380789
- Gut Liver.
- 2015 Jan;9(1):103-108.
- doi: 10.5009/gnl14018
BACKGROUND/AIMS: To investigate the association between the baseline profiles and dynamics of hepatitis B virus (HBV) DNA polymerase gene mutations and the long-term virological response of lamivudine (LAM)-adefovir (ADV) combination... -
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- The efficacy of adefovir dipivoxil monotherapy and the incidence of genotypic resistance to adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B infection
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Moon JH, Cho M, Yoon KT, Bae JH, Heo J, Kim GH, Kang DH, Song GA
- KMID: 1073302
- Korean J Hepatol.
- 2008 Dec;14(4):503-512.
- doi: 10.3350/kjhep.2008.14.4.503
BACKGROUND/AIMS: Adefovir dipivoxil (ADV) is a nucleotide analogue that inhibits wild-type hepatitis B virus (HBV) and lamivudine (LMV)-resistant HBV mutants. The aim of this study was to elucidate the... -
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- Overlapping Gene Mutations of Hepatitis B Virus in a Chronic Hepatitis B Patient with Hepatitis B Surface Antigen Loss during Lamivudine Therapy
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Lee SY, Choi MS, Lee D, Lee JH, Koh KC, Paik SW, Yoo BC
- KMID: 1778502
- J Korean Med Sci.
- 2005 Jun;20(3):433-437.
- doi: 10.3346/jkms.2005.20.3.433
Disappearance of hepatitis B surface antigens (HBsAg) in chronic hepatitis B usually indicates clearance of hepatitis B virus (HBV) infection. However, false HBsAg negativity with mutations in pre-S2 and 'a'... -
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