- Expression of DNA Topoisomerase II and P-Glycoprotein in Breast Cancer
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Park HR, Jung EH, Sohn JH, Park YE
- KMID: 2175461
- J Korean Cancer Assoc.
- 1997 Apr;29(2):242-249.
PURPOSE: To determine whether the expression of DNA topoisomerase II and P-glycoprotein are of prognostic value. MATERIALS AND METHODS: We evaluated the expression of DNA topoisomerase II and P-glycoprotein immunohistochemically... -
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- Localization of DNA Topoisomerase II on High Salt Extract Chromatin Fraction of Mouse Embry Fibroblast Cells Treated with Bezo(a)pyrene and Doxorubicin
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Lee DG, Kim JG, Jung IC, Cho MY
- KMID: 2260972
- Korean J Obstet Gynecol.
- 1998 May;41(5):1437-1445.
This study was conducted to determine if there exists a DNA topoisomerase II participating in the cleave and rejoining of DNA in the nuclear fraction of a mouse embryo fibroblast,... -
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- Altered Expression of DNA Topoisomerase IIalpha, Ki-67, p53 and p27 in Non-Hodgkin's Lymphoma
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Lee KM, Sol MY, Kang HJ, Shin DH, Choi KU, Kim HW, Kim JY, Park DY, Lee CH
- KMID: 1598234
- Korean J Pathol.
- 2005 Oct;39(5):332-337.
BACKGROUND: Topoisomerase II (TOPO II) is an enzyme that separates intertwined chromosomes during DNA synthesis by transiently breaking and joining DNA strands. The level of TOP II is one of... -
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- Multidrug Resistance-Related Gene Expressions in Germ Cell Tumors in Testis
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Lee JW, Lee SC, Kim WJ
- KMID: 2290041
- Korean J Urol.
- 1996 Apr;37(4):392-400.
The development of drug resistance is a major obstacle in effective cancer chemotherapy. Multidrug resistance(MDR) is a widely studied phenomenon of interest to both clinicians and research workers because many... -
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- Reduced Levofloxacin Susceptibility in Clinical Respiratory Isolates of Haemophilus Influenzae Is Not yet Associated with Mutations in the DNA Gyrase and Topoisomerase II Genes in Korea
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Kim IS, Lee NY, Kim S, Ki CS, Kim SH
- KMID: 1106455
- Yonsei Med J.
- 2011 Jan;52(1):188-191.
- doi: 10.3349/ymj.2011.52.1.188
Among 155 clinical respiratory isolates of Haemophilus influenzae in Korea, 6 (3.9%) isolates had reduced levofloxacin susceptibility (MICs > or = 0.5 microg/mL). These six isolates had no significant quinolone... -
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- Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90
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Jun KY, Kwon Y
- KMID: 2351668
- Biomol Ther.
- 2016 Sep;24(5):453-468.
- doi: 10.4062/biomolther.2016.168
There is a conserved ATPase domain in topoisomerase II (topo II) and heat shock protein 90 (Hsp90) which belong to the GHKL (gyrase, Hsp90, histidine kinase, and MutL) family. The... -
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- Expression of Topoisomerase II alpha and Ki-67 in Invasive Mammary Carcinoma and Their Clinicopathologic Implication
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Oh SM, Kim DC, Cho SH
- KMID: 2211097
- J Korean Surg Soc.
- 2007 Sep;73(3):204-209.
PURPOSE: Various prognostic indicators have been identified for mammary carcinomas, but the issue of their significance remains unsettled. The prognostic impact of c-erb B2, Ki-67 and topoisomerase II alpha expression... -
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- Identification of Candida Species by Multiplex Polymerase Chain Reaction
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Lee MK, Kim HR, Lee YJ
- KMID: 2224724
- Korean J Clin Microbiol.
- 2006 Oct;9(2):119-124.
BACKGROUND: Polymerase chain reacation (PCR)-based methods have been described for rapid detection and identification of Candida spp. Multiplex PCR assay was developed using internal transcribed spacers and topoisomerase II gene... -
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- Role of ATF on Transcriptional Regulation of DNA Topoisomerase II a Gene in HL - 60 Arrested to G2 / M and M Phase
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Lim K, Son MY, Choi BI, Yun KA, Zheng M, Kang TW, Lee YC, Park JI, Yoon WH, Hwang BD
- KMID: 2175140
- J Korean Cancer Assoc.
- 1999 Dec;31(6):1279-1287.
PURPOSE: To gain insight on transcriptional repression of Topo II a in HL-60 cells arrested to G2/M and M phase, the levels of Topo IIa mRNA and the binding activity... -
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- A Study Tumoric Topoisomerase II alpha enzyme, c-erb B-2oncoprotein, and P-glycoprotein Expression as an Indicator of Therapeutic Failure in Breast Cancer Patients Received Chemotherapy
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Kim WH, Yoon JH, Jaegal YJ, Park CS
- KMID: 2173616
- J Korean Breast Cancer Soc.
- 1999 Dec;2(2):211-220.
- doi: 10.4048/jkbcs.1999.2.2.211
It is deirable to identify the tumoric factors anticipating the therapeutic failure in breast cancer patients received postoperative adjuvant chemotherapy. So, we studued the tumoric topoisomerase II alpha enzyme, c-erbB-2... -
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- Proliferative Markers of Breast Cancer
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Bok SH, Gwag G, Yang KH, Bae BN, Kim KH, Kim HJ, Kim YD, Kim HY, Park K, Han S
- KMID: 1963235
- J Breast Cancer.
- 2005 Dec;8(4):165-171.
- doi: 10.4048/jbc.2005.8.4.165
PURPOSE: The mitotic index (MI) and Ki-67 labeling index have been used as cell proliferative markers in the various tumors. Topoisomerase II alpha (Topo II alpha) is also expressed in... -
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- Expression of Ki-67 and Topoisomerase IIa in Human Middle Ear Cholesteatoma Epithelium
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Suh HK, Lee ES, Choi JH, Jun BS, Song JJ, Lim HH, Hwang SJ
- KMID: 2115393
- Korean J Otolaryngol-Head Neck Surg.
- 1999 Aug;42(8):950-954.
BACKGROUND AND OBJECTIVES: Cholesteatoma is a destructive lesion of the middle ear or mastoid process. The development of human cholesteatoma is due to the altered control of cellular proliferation in... -
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- Genistein Induced Inginition of Cell Proliferation and Programmed Cell Death in the Human Cancer Cell Lines
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Choi YH, Lee SJ, Kim M, Zhang L, Lee WH, Park KY
- KMID: 2006874
- J Korean Cancer Assoc.
- 1998 Aug;30(4):800-808.
PURPOSE: Genistein, a natural isoflavonoid phyto-oestrogen present in plant foods including citrus fruits and soybean, is a specific inhibitor of tyrosine kinase and topoisomerase II. In this paper we examined... -
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- Immunohistochemical Study on the Expression of Topoisomerase II alpha and Glutathione S-Transferase pi in Acute Myeloid Leukemia
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Kim BK, Jeong YS, Chang CH, Son HC, Kim SH, Sol MY, Lee EY
- KMID: 2089488
- Korean J Clin Pathol.
- 1998 Jun;18(2):107-114.
BACKGROUND: Topoisomerase II (topo II) is a major target of anthracyclines and epipodophyllotoxins for anticancer treatment. The expression of topo II is low in drug resistant cell lines. High levels... -
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- Value of urinary topoisomerase-IIA cell-free DNA for diagnosis of bladder cancer
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Kim YH, Yan C, Lee IS, Piao XM, Byun YJ, Jeong P, Kim WT, Yun SJ, Kim WJ
- KMID: 2363132
- Investig Clin Urol.
- 2016 Mar;57(2):106-112.
- doi: 10.4111/icu.2016.57.2.106
PURPOSE: Topoisomerase-II alpha (TopoIIA ), a DNA gyrase isoform that plays an important role in the cell cycle, is present in normal tissues and various human cancers, and can show... -
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- Expression of Multidrug Resistant Genes in Bone Marrow Mononuclear Cells of Patients with Myeloid Leukemia
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Cho SG, Yang IH, Eom HS, Min CG, Kim HJ, Kim DW, Lee JW, Han CW, Min WS, Kim WI, Kim CC
- KMID: 2175286
- J Korean Cancer Assoc.
- 1999 Feb;31(1):153-164.
PURPOSE: Multidrug resistance mediated by several drug resistant genes impedes the successful outcome of anti-cancer chemotherapy. In this study, we investigated the expressions of drug resistant genes encoding multidrug resistance... -
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- The Expression of Topoisomerase II alpha in the Gastric Carcinoma
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Kim SJ, Yoon CM, Rew JS, Choi SK, Park CS, Koo C
- KMID: 2240625
- Korean J Gastroenterol.
- 1998 Apr;31(4):477-488.
BACKGROUND AND AIMS: Topoisomerase IIa (Topo IIa) separates chromosomes at the end of mitosis and thus, is the target for various chemotherapeutic agents. Expression of this enzyme has been demonstrated... -
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- Effect of TNF-alpha Gene Transfer to Respiratory Cancer Cell Lines onSensitivity to Anticancer drugs
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Mo EK, Lee JH, Lee KY, Yoo CG, Kim YW, Han SK, Shim YS, Choi HS
- KMID: 2317910
- Tuberc Respir Dis.
- 1995 Jun;42(3):302-313.
BACKGROUND: Tumor necrosis factor(TNF) showed antitumor cytolytic effects on sensitive tumor cells in numerous in vivo and in vitro studies. But it could not be administered systemically to human because... -
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- Cytotoxicity and Structure-activity Relationships of Naphthyridine Derivatives in Human Cervical Cancer, Leukemia, and Prostate Cancer
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Hwang YJ, Chung ML, Sohn UD, Im C
- KMID: 2285479
- Korean J Physiol Pharmacol.
- 2013 Dec;17(6):517-523.
- doi: 10.4196/kjpp.2013.17.6.517
Naphthyridine compounds are important, because they exhibit various biological activities including anticancer, antimicrobial, and anti-inflammatory activity. Some naphthyridines have antimitotic effects or demonstrate anticancer activity by inhibiting topoisomerase II. These... -
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- Multiplication of Chromosome 17 Centromere Is Associated with Prognosis in Patients with Invasive Breast Cancers Exhibiting Normal HER2 and TOP2A Status
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Kim A, Shin HC, Bae YK, Kim MK, Kang SH, Lee SJ, Lee EH
- KMID: 2286470
- J Breast Cancer.
- 2012 Mar;15(1):24-33.
- doi: 10.4048/jbc.2012.15.1.24
PURPOSE: This study aimed to investigate the clinical significance of chromosome 17 centromere (CEP17) multiplication (increased copy number of CEP17) related to human epidermal growth factor receptor 2 (HER2) and... -
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