- Methylation Pattern of DNA Repair Genes and Microsatellite Instability in Hepatocelluar Carcinoma
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Park JH, Cho SB, Lee WS, Park CH, Joo YE, Kim HS, Choi SK, Rew JS, Lee JH, Kim SJ
- KMID: 1113480
- Korean J Gastroenterol.
- 2006 Nov;48(5):327-336.
BACKGROUND/AIMS: Epigenetic silencing of DNA repair genes, O6-methylguanine-DNA methyltransferase (MGMT), hMLH1 and hMSH3, by promoter hypermethylation have been observed in various cancers. However, the relationship between hypermethylation of DNA... -
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- DNA mismatch repair-related protein loss as a prognostic factor in endometrial cancers
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Kato M, Takano M, Miyamoto M, Sasaki N, Goto T, Tsuda H, Furuya K
- KMID: 2158801
- J Gynecol Oncol.
- 2015 Jan;26(1):40-45.
- doi: 10.3802/jgo.2015.26.1.40
OBJECTIVE: Recent investigations have revealed DNA mismatch repair (MMR) gene mutations are closely related with carcinogenesis of endometrial cancer; however the impact of MMR protein expression on prognosis is not... -
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- Germline and somatic mutations in homologous recombination genes among Chinese ovarian cancer patients detected using next-generation sequencing
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Zhao Q, Yang J, Li L, Cao D, Yu M, Shen K, the BGI Group
- KMID: 2413427
- J Gynecol Oncol.
- 2017 Jul;28(4):e39.
- doi: 10.3802/jgo.2017.28.e39
OBJECTIVE: To define genetic profiling of homologous recombination (HR) deficiency in Chinese ovarian cancer patients. METHODS: we have applied next-generation sequencing to detect deleterious mutations through all exons in 31 core... -
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- A Consideration of MGMT Gene Promotor Methylation Analysis for Glioblastoma Using Methylation-Specific Polymerase Chain Reaction and Pyrosequencing
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Lee SH, Hwang TS, Koh YC, Kim WY, Han HS, Kim WS, Ko YS, Lim SD
- KMID: 2277516
- Korean J Pathol.
- 2011 Feb;45(1):21-29.
BACKGROUND: O6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation is currently the most promising predictive marker for the outcome and benefit from temozolomide treatment in patients with glioblastoma, but there is no... -
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- Clinicopathological Characteristics of Colorectal Cancer with Family History: an Evaluation of Family History as a Predictive Factor for Microsatellite Instability
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Park IJ, Kim HC, Yoon YS, Yu CS, Jang SJ, Kim JC
- KMID: 1785795
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S91-S97.
- doi: 10.3346/jkms.2007.22.S.S91
To determine whether family history of cancer may be a risk factor for the mutator phenotype in colorectal cancer, we recruited 143 consecutive colorectal cancer patients with a family history... -
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- Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells
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Choi JH, Kim JS, Kim YC, Kim YS, Chung NH, Cho MH
- KMID: 1094683
- J Vet Sci.
- 2004 Mar;5(1):11-18.
Accurate estimation of the exposure-response relationship between ambient urban particulate matters (PM) and public health is important for regulatory perspective of ambient urban particulate matters (PM). Ambient PM contains various... -
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- Time-course analysis of DNA damage response-related genes after in vitro radiation in H460 and H1229 lung cancer cell lines
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Kim KH, Yoo HY, Joo KM, Jung Y, Jin J, Kim Y, Yoon SJ, Choi SH, Seol HJ, Park WY, Nam DH
- KMID: 1015461
- Exp Mol Med.
- 2011 Jul;43(7):419-426.
- doi: 10.3858/emm.2011.43.7.046
Radiation is the most useful treatment modality for cancer patients. It initiates a series of signal cascades such as DNA damage response (DDR) signaling for repairing damaged DNA, arresting the... -
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