- Expression of Th1 and Th2 type cytokines responding to HBsAg and HBxAg in chronic hepatitis B patients
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Lee M, Lee MA, Lee SK, Son M, Cho SW, Park S, Kim HI
- KMID: 648077
- J Korean Med Sci.
- 1999 Apr;14(2):175-181.
- doi: 10.3346/jkms.1999.14.2.175
The cytokine pattern on viral antigen recognition is believed to exert a profound influence on the resolution of viral infections and viral clearance. This study was initiated to investigate whether... -
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- Role of Endoplasmic Reticulum Stress in Rheumatoid Arthritis Pathogenesis
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Park YJ, Yoo SA, Kim WU
- KMID: 1796908
- J Korean Med Sci.
- 2014 Jan;29(1):2-11.
- doi: 10.3346/jkms.2014.29.1.2
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by abnormal proliferation of synoviocytes, leukocyte infiltration, and angiogenesis. The endoplasmic reticulum (ER) is the site of biosynthesis for all secreted... -
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- Protease-Activated Receptor 2 Is Involved in Th2 Responses against Trichinella spiralis Infection
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Park MK, Cho MK, Kang SA, Park HK, Kim YS, Kim KU, Ahn SC, Kim DH, Yu HS
- KMID: 1715646
- Korean J Parasitol.
- 2011 Sep;49(3):235-243.
- doi: 10.3347/kjp.2011.49.3.235
In order to get a better understanding of the role of protease-activated receptor 2 (PAR2) in type 2 helper T (Th2) cell responses against Trichinella spiralis infection, we analyzed Th2... -
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- Streptococcal infection in the pathogenesis of Behcet's disease and clinical effects of minocycline on the disease symptoms
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Kaneko F, Oyama N, Nishibu A
- KMID: 2158074
- Yonsei Med J.
- 1997 Dec;38(6):444-454.
- doi: 10.3349/ymj.1997.38.6.444
Although the precise pathoetiology of Behcet's disease (BD) remains obscure, patients with BD have a high incidence of chronic infectious foci, indicating an enhanced susceptibility to chronic tonsillitis, and dental... -
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- Activated natural killer cell-mediated immunity is required for the inhibition of tumor metastasis by dendritic cell vaccination
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Kim A, Noh YW, Kim KD, Jang YS, Choe YK, Lim JS
- KMID: 1123764
- Exp Mol Med.
- 2004 Oct;36(5):428-443.
Immunization with dendritic cells (DCs) pulsed with tumor antigen can activate tumor-specific cytotoxic T lymphocytes (CTL), which is responsible for tumor protection and regression. In this study, we examined whether... -
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- Eupatilin Ameliorates Collagen Induced Arthritis
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Kim J, Kim Y, Yi H, Jung H, Rim YA, Park N, Jung SM, Park SH, Ju JH
- KMID: 2133298
- J Korean Med Sci.
- 2015 Mar;30(3):233-239.
- doi: 10.3346/jkms.2015.30.3.233
Eupatilin is the main active component of DA-9601, an extract from Artemisia. Recently, eupatilin was reported to have anti-inflammatory properties. We investigated the anti-arthritic effect of eupatilin in a murine... -
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- Negative regulatory approaches to the attenuation of Toll-like receptor signaling
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Anwar MA, Basith S, Choi S
- KMID: 2154230
- Exp Mol Med.
- 2013 Feb;45(2):e11.
Toll-like receptors (TLRs) are pivotal components of the innate immune response, which is responsible for eradicating invading microorganisms through the induction of inflammatory molecules. These receptors are also involved in... -
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- Alveolar macrophages modulate allergic inflammation in a murine model of asthma
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Bang BR, Chun E, Shim EJ, Lee HS, Lee SY, Cho SH, Min KU, Kim YY, Park HW
- KMID: 1009966
- Exp Mol Med.
- 2011 May;43(5):275-280.
- doi: 10.3858/emm.2011.43.5.028
The role of alveolar macrophages (AMs) in the pathogenesis of asthma is still unknown. The aim of the present study was to investigate the effects of AM in the murine... -
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- B cell-associated immune profiles in patients with end-stage renal disease (ESRD)
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Kim KW, Chung BH, Jeon EJ, Kim BM, Choi BS, Park CW, Kim YS, Cho SG, Cho ML, Yang CW
- KMID: 1387357
- Exp Mol Med.
- 2012 Aug;44(8):465-472.
Most of the previous studies on immune dysregulation in end-stage renal disease (ESRD) have focused on T cell immunity. We investigated B cell subpopulations in ESRD patients and the effect... -
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- Anti-tumor immunostimulatory effect of heat-killed tumor cells
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Yoon TJ, Kim JY, Kim H, Hong C, Lee H, Lee CK, Lee KH, Hong S, Park SH
- KMID: 1103596
- Exp Mol Med.
- 2008 Feb;40(1):130-144.
- doi: 10.3858/emm.2008.40.1.130
As a part of our ongoing search for a safe and efficient anti-tumor vaccine, we attempted to determine whether the molecular nature of certain tumor antigens would influence immune responses... -
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- Potential use of an anticancer drug gefinitib, an EGFR inhibitor, on allergic airway inflammation
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Hur GY, Lee SY, Lee SH, Kim SJ, Lee KJ, Jung JY, Lee EJ, Kang EH, Jung KH, Lee SY, Kim JH, Shin C, Shim JJ, In KH, Kang KH, Yoo SH
- KMID: 1047088
- Exp Mol Med.
- 2007 Jun;39(3):367-375.
The EGFR plays an essential role in goblet cell hyperplasia and mucus hypersecretion. EGFR has an intrinsic tyrosine kinase activity that, when activated, induces the production of MUC5AC through the... -
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- Isolation of perchloric acid soluble, heat stable, ethanol extractable protein from Mycobacterium tuberculosis
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Kim DS, Han BH, Lee KY
- KMID: 699911
- Yonsei Med J.
- 1996 Oct;37(5):339-349.
- doi: 10.3349/ymj.1996.37.5.339
The perchloric acid soluble, heat stable, and ethanol insoluble antigen of M. tuberculosis (TB-PBE) was prepared, and antigenicity of this antigen was studied in vivo and in vitro. TB-PBE showed... -
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- Molecular Targets of Dietary Polyphenols with Anti-inflammatory Properties
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Yoon JH, Baek SJ
- KMID: 2158137
- Yonsei Med J.
- 2005 Oct;46(5):585-596.
- doi: 10.3349/ymj.2005.46.5.585
There is persuasive epidemiological and experimental evidence that dietary polyphenols have anti-inflammatory activity. Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) have long been used to combat inflammation. Recently, cyclooxygenase (COX)... -
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- Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression
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Kim DH, Cho IH, Kim HS, Jung JE, Kim JE, Lee KH, Park T, Yang YM, Seong SY, Ye SK, Chung MH
- KMID: 1110126
- Exp Mol Med.
- 2006 Aug;38(4):417-427.
To elucidate the roles of 8-hydroxydeoxyguanosine (oh8dG), the nucleoside of 8-hydroxyguanine (oh8Gua), we examined the effects of oh8dG upon LPS-induced intercellular adhesion molecule-1 (ICAM-1) expression and the underlying mechanisms in... -
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- Early ultrastructural changes of apoptosis induced by fumonisin B1 in rat liver
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Moon WS, Kim JH, Kang MJ, Lee DG
- KMID: 1758509
- Yonsei Med J.
- 2000 Apr;41(2):195-204.
- doi: 10.3349/ymj.2000.41.2.195
A time sequential study was performed to investigate the histological and ultrastructural findings of fumonisin B1-induced apoptosis in the male Sprague-Dawley rat liver. Six hours after administration of FB1, marked... -
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- Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody
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Jung DY, Kim EY, Joo SY, Park JB, Moon C, Kim SH, Sim EY, Joh JW, Kwon CH, Kwon GY, Kim SJ
- KMID: 1103582
- Exp Mol Med.
- 2008 Feb;40(1):1-10.
- doi: 10.3858/emm.2008.40.1.1
Pancreatic islet transplantation can correct the abnormal glucose metabolism of Type 1 diabetes. Although immunosuppressants greatly reduce the acute rejection rate in transplant patients, the long-term side effects can be... -
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- Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells
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Park SN, Noh KT, Jeong YI, Jung ID, Kang HK, Cha GS, Lee SJ, Seo JK, Kang DH, Hwang TH, Lee EK, Kwon B, Park YM
- KMID: 2154227
- Exp Mol Med.
- 2013 Feb;45(2):e8.
We evaluated the effectiveness of rhamnogalacturonan II (RG-II)-stimulated bone marrow-derived dendritic cells (BMDCs) vaccination on the induction of antitumor immunity in a mouse lymphoma model using EG7-lymphoma cells expressing ovalbumin... -
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- Single Nucleotide Polymorphisms of Cytokine Genes are Associated with Fibrosis of the Intrahepatic Bile Duct Wall in Human Clonorchiasis
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Chung BS, Lee JK, Choi MH, Park MH, Choi D, Hong ST
- KMID: 1720624
- Korean J Parasitol.
- 2009 Jun;47(2):145-151.
- doi: 10.3347/kjp.2009.47.2.145
This study examined the association of cytokine gene polymorphisms with intrahepatic bile duct wall fibrosis in human clonorchiasis. A total of 240 residents in Heilongjiang, China underwent ultrasonography, blood sampling,... -
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