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N-acetyl-l-cysteine controls osteoclastogenesis through regulating Th17 differentiation and RANKL in rheumatoid arthritis

Kim HR, Kim KW, Kim BM, Lee KA, Lee SH

BACKGROUND/AIMS: This study aimed to determine the regulatory role of N-acetyl-l-cysteine (NAC), an antioxidant, in interleukin 17 (IL-17)-induced osteoclast differentiation in rheumatoid arthritis (RA). METHODS: After RA synovial fibroblasts were stimulated...
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Molecular and Biochemical Properties of a Cysteine Protease of Acanthamoeba castellanii

Hong Y, Kang JM, Joo SY, Song SM, Lê HG, Thái TL, Lee J, Goo YK, Chung DI, Sohn WM, Na BK

Acanthamoeba spp. are free-living protozoa that are opportunistic pathogens for humans. Cysteine proteases of Acanthamoeba have been partially characterized, but their biochemical and functional properties are not clearly understood yet....
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Promoter methylation of cysteine dioxygenase type 1: gene silencing and tumorigenesis in hepatocellular carcinoma

Choi JI, Cho EH, Kim SB, Kim R, Kwon J, Park M, Shin HJ, Ryu HS, Park SH, Lee KH

BACKGROUNDS/AIMS: Cysteine dioxygenase type 1 (CDO1) acts as a tumor suppressor and is silenced by promoter methylation in various malignancies. The relationship between the CDO1 methylation status and hepatocellular carcinoma...
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N-acetyl-L-cysteine and cysteine increase intracellular calcium concentration in human neutrophils

Hasan MA, Ahn WG, Song DK

N-acetyl-L-cysteine (NAC) and cysteine have been implicated in a number of human neutrophils' functional responses. However, though Ca²⁺ signaling is one of the key signalings contributing to the functional responses...
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N-Acetyl Cysteine in the Treatment of Obsessive Compulsive and Related Disorders: A Systematic Review

Oliver G, Dean O, Camfield D, Blair-West S, Ng C, Berk M, Sarris J

OBJECTIVE: Obsessive compulsive and related disorders are a collection of debilitating psychiatric disorders in which the role of glutamate dysfunction in the underpinning neurobiology is becoming well established. N-acetyl cysteine...
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Effects of Ambroxol, S-carboxymethylcysteine, Dextromethorphan and Noscapine on Mucin Release from Airway Goblet Cells

Heo HJ, Lee HJ, Yoon CS, Lim SP, Seok JH, Seo UK, Lee CJ

  • KMID: 2071614
  • Korean J Physiol Pharmacol.
  • 2005 Dec;9(6):323-326.
In the present study, we investigated whether ambroxol, S-carboxymethyl-L-cysteine, dextromethorphan and noscapine affect mucin release from airway goblet cells. Confluent primary hamster tracheal surface epithelial cells were metabolically radiolabeled and...
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The Effects of Prostaglandin E1 and N-Acetyl-L-Cysteine for Ischemic Renal Reperfusion Injury in the Rat

Cho MY, Jung SI, Cho WY, Kim HK, Won NH, Choi SY, Whang CW

  • KMID: 2096990
  • J Korean Soc Transplant.
  • 1999 Dec;13(2):229-242.
BACKGROUND: Some studies has showed that even though reperfusion is essential for the recovery of renal function, it, itself, might be caused of renal injury through liberation of oxygen free...
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Effect of N-Acetylcysteine on the Superoxide Release, Chemotaxis from the Neutrophils and Glutathione Level of Plasma and Neutrophils

Song JS, Lee SY, Moon HS, Park SH

  • KMID: 2317877
  • Tuberc Respir Dis.
  • 1994 Oct;41(5):475-483.
BACKGROUND: N-acetylcysteine(ACE) is used both orally and intravenously in a variety of experimental pathologies resembling human disease states which exhibit endothelial toxicity as a result of oxidative stress, including acute...
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