- Sugammadex: clinical development and practical use
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Fuchs-Buder T, Meistelman C, Raft J
- KMID: 2092374
- Korean J Anesthesiol.
- 2013 Dec;65(6):495-500.
- doi: 10.4097/kjae.2013.65.6.495
Sugammadex is belonging to a new class of drugs: the selective relaxant binding agents. Sugammadex can reverse residual paralysis by encapsulating free circulating non depolarizing muscle relaxants. The mains advantages... -
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- Clinical use of sugammadex
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Kim KS
- KMID: 2263228
- Anesth Pain Med.
- 2011 Oct;6(4):307-313.
An ideal reversal agent could be given at any time after the administration of a neuromuscular blocking agent, and should have no muscarinic side-effects. Sugammadex is a modified gamma-cyclodextrin designed... -
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- In the hour of Sugammadex
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Chon JY
- KMID: 2236226
- Korean J Anesthesiol.
- 2013 Jan;64(1):3-5.
- doi: 10.4097/kjae.2013.64.1.3
Sugammadex is a modified gamma-cyclodextrin which is showing favorable outcomes regarding reversal of neuromuscular blockade, especially by rocuronium. It is designed to encapsulate rocuronium and being considered a new class... -
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- Effect of Cholesterol Depletion on Interleukin-8 Production in Human Respiratory Epithelial Cells
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Kim MJ, Hong JY, Lee KE, Kim KW, Sohn MH, Kim KE
- KMID: 2260285
- Allergy Asthma Immunol Res.
- 2013 Nov;5(6):402-408.
- doi: 10.4168/aair.2013.5.6.402
PURPOSE: The lipid entities of cell membranes are components of the immune system and important mediators of inflammation. Despite increasing interest in the function of epithelial cells in inflammation, the... -
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- Cholesterol Depletion in Cell Membranes of Human Airway Epithelial Cells Suppresses MUC5AC Gene Expression
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Song KJ, Kim NH, Lee GB, Kim JH, Kwon JH, Kim KS
- KMID: 1727882
- Yonsei Med J.
- 2013 May;54(3):679-685.
- doi: 10.3349/ymj.2013.54.3.679
PURPOSE: If cholesterol in the cell membrane is depleted by treating cells with methyl-beta-cyclodextrin (MbetaCD), the activities of transmembrane receptors are altered in a cell-specific and/or receptor-specific manner. The proinflammatory... -
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- Cholesterol, a Major Component of Caveolae, Down-regulates Matrix Metalloproteinase-1 Expression through ERK/JNK Pathway in Cultured Human Dermal Fibroblasts
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Kim S, Han J, Lee DH, Cho KH, Kim KH, Chung JH
- KMID: 2266173
- Ann Dermatol.
- 2010 Nov;22(4):379-388.
- doi: 10.5021/ad.2010.22.4.379
BACKGROUND: Cholesterol is a major component of specialized membrane microdomains known as lipid rafts or caveolae, which modulate the fluidity of biological membranes. Membrane cholesterol therefore plays an important role... -
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- Methyl-beta-cyclodextrin inhibits cell growth and cell cycle arrest via a prostaglandin E(2) independent pathway
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Choi YA, Chin BR, Rhee DH, Choi HG, Chang HW, Kim JH, Baek SH
- KMID: 755669
- Exp Mol Med.
- 2004 Feb;36(1):78-84.
Methyl-beta-cyclodextrin, a cyclic oligosaccharide known for its interaction with the plasma membrane induces several events in cells including cell growth and anti-tumor activity. In this study, we have investigated the... -
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- GD3 Accumulation in Cell Surface Lipid Rafts Prior to Mitochondrial Targeting Contributes to Amyloid-beta-induced Apoptosis
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Kim JK, Kim SH, Cho HY, Shin HS, Sung HR, Jung JR, Quan ML, Jiang DH, Bae HR
- KMID: 2157855
- J Korean Med Sci.
- 2010 Oct;25(10):1492-1498.
- doi: 10.3346/jkms.2010.25.10.1492
Neuronal apoptosis induced by amyloid beta-peptide (A beta) plays an important role in the pathophysiology of Alzheimer's disease (AD). However, the molecular mechanism underlying A beta-induced apoptosis remains undetermined. The... -
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- Induction of tissue inhibitor of matrix metalloproteinase-2 by cholesterol depletion leads to the conversion of proMMP-2 into active MMP-2 in human dermal fibroblasts
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Kim S, Oh JH, Lee Y, Lee J, Cho KH, Chung JH
- KMID: 946668
- Exp Mol Med.
- 2010 Jan;42(1):38-46.
- doi: 10.3858/emm.2010.42.1.004
Cholesterol is one of major components of cell membrane and plays a role in vesicular trafficking and cellular signaling. We investigated the effects of cholesterol on matrix metalloproteinase-2 (MMP-2) activation... -
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