- Expression of Cyclin Dependent Kinase Inhibitors of KIP Family in Gastric Cancer
-
Lee SJ, Joo YE, Kim HS, Choi SK, Rew JS, Park CS, Kim SJ
- KMID: 1113428
- Korean J Gastroenterol.
- 2005 Aug;46(2):84-93.
BACKGROUND/AIMS: The cyclin-dependent kinase inhibitors (CDKI) including p21, p27, and p57 of the kinase inhibitor protein (KIP) family are negative regulators of cell cycle progression and potentially act as... -
- CITED
-
- Close
- SHARE
-
- Close
- Expression of G1 Cell Cycle Regulators in Rat Liver upon Repeated Exposure to Thioacetamide
-
Kim KT, Han SY, Jeong JS
- KMID: 760708
- Korean J Hepatol.
- 2007 Mar;13(1):81-90.
BACKGROUND/AIMS: Eukaryotic cell cycle is regulated by signal transduction pathways mediated by complexes of cyclin dependent kinases (CDKs) and their partner cyclins, or by interaction with CDK inhibitors. Thioacetamide... -
- CITED
-
- Close
- SHARE
-
- Close
- The Effects of p21 on Bladder Cancers
-
Jung W, Cho IC, Ha YS, Jo SH, Park MS, Lee YS, Yoon SJ, Kim WJ
- KMID: 2294271
- Korean J Urol.
- 2006 Nov;47(11):1149-1154.
- doi: 10.4111/kju.2006.47.11.1149
Purpose: p21 protein is an inhibitor of cyclin-dependent kinases, which may be able to arrest the cell cycle at the G1 phase by inhibiting DNA replication through the interaction with... -
- CITED
-
- Close
- SHARE
-
- Close
- Aberrant Cell Cycle Regulation in Cervical Carcinoma
-
Kim YT, Zhao M
- KMID: 2158138
- Yonsei Med J.
- 2005 Oct;46(5):597-613.
- doi: 10.3349/ymj.2005.46.5.597
Carcinoma of the uterine cervix is one of the most common malignancies among women worldwide. Human papillomaviruses (HPV) have been identified as the major etiological factor in cervical carcinogenesis. However,... -
- CITED
-
- Close
- SHARE
-
- Close
- The role of p21/CIP1/WAF1 (p21) in the negative regulation of the growth hormone/growth hormone receptor and epidermal growth factor/epidermal growth factor receptor pathways, in growth hormone transduction defect
-
Kostopoulou E, Rojas Gil , Spiliotis
- KMID: 2432278
- Ann Pediatr Endocrinol Metab.
- 2018 Dec;23(4):204-209.
- doi: 10.6065/apem.2018.23.4.204
PURPOSE: Growth hormone transduction defect (GHTD) is characterized by severe short stature, impaired STAT3 (signal transducer and activator of transcription-3) phosphorylation and overexpression of the cytokine inducible SH2 containing protein... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of p21CIP1 as a determinant of SC-560 response in human HCT116 colon carcinoma cells
-
Lee E, Choi MK, Han IO, Lim SJ
- KMID: 1094159
- Exp Mol Med.
- 2006 Jun;38(3):325-331.
SC-560, a strucutral analogue of celecoxib, induces growth inhibition in a wide range of human cancer cells in a cyclooxygenase (COX)-independent manner. Since SC-560 suppresses the growth of cancer cells... -
- CITED
-
- Close
- SHARE
-
- Close
- Trichostatin A-mediated upregulation of p21
-
Yi T, Baek JH, Kim HJ, Choi MH, Seo SB, Ryoo HM, Kim GS, Woo KM
- KMID: 1094662
- Exp Mol Med.
- 2007 Apr;39(2):213-221.
Histone deacetylase inhibitors (HDIs), a new class of anti-cancer agents, have been reported to suppress formation of osteoclast precursors and their fusion into multinucleated cells. However, little is known about... -
- CITED
-
- Close
- SHARE
-
- Close
- Low-dose radiation response of the p21(WAF1/CIP1) gene promoter transduced by adeno-associated virus vector
-
Nenoi M, Daino K, Ichimura S, Takahash S, Akuta T
- KMID: 1098090
- Exp Mol Med.
- 2006 Oct;38(5):553-564.
In cancer gene therapy, restriction of antitumor transgene expression in a radiation field by use of ionizing radiation-inducible promoters is one of the promising approaches for tumor-specific gene delivery. Although... -
- CITED
-
- Close
- SHARE
-
- Close
- Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor via mitogen-activated protein kinase
-
Jung GA, Shin BS, Jang YS, Sohn JB, Woo SR, Kim JE, Choi G, Lee KM, Min BH, Lee KH, Park GH
- KMID: 1123367
- Exp Mol Med.
- 2011 Oct;43(10):550-560.
- doi: 10.3858/emm.2011.43.10.061
Protein arginine methylation is important for a variety of cellular processes including transcriptional regulation, mRNA splicing, DNA repair, nuclear/cytoplasmic shuttling and various signal transduction pathways. However, the role of arginine... -
- CITED
-
- Close
- SHARE
-
- Close
- Growth Inhibition of Hepatocellular Carcinoma Huh7 Cells by Lactobacillus casei Extract
-
Han DJ, Kim JB, Park SY, Yang MG, Kim H
- KMID: 1793166
- Yonsei Med J.
- 2013 Sep;54(5):1186-1193.
- doi: 10.3349/ymj.2013.54.5.1186
PURPOSE: Lactobacillus casei (L. casei) is known to exert anti-proliferation effects on many types of cancer cells. However, the effect of L. casei on liver cancer has not been reported.... -
- CITED
-
- Close
- SHARE
-
- Close
- The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells
-
Kim WG, Choi HJ, Kim TY, Shong YK, Kim WB
- KMID: 2070111
- Korean J Intern Med.
- 2014 Jul;29(4):474-481.
BACKGROUND/AIMS: 5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a cellular energy sensor that monitors intracellular AMP/adenosine triphosphate (ATP) ratios and is a key regulator of the proliferation and survival of... -
- CITED
-
- Close
- SHARE
-
- Close
- The orphan nuclear receptor SHP inhibits apoptosis during the monocytic differentiation by inducing p21WAF1
-
Kim K, Choi YH, Kim HH, Cheong J
- KMID: 756235
- Exp Mol Med.
- 2009 Jun;41(6):429-439.
- doi: 10.3858/emm.2009.41.6.048
Small heterodimer partner (SHP) is an atypical member of nuclear receptor superfamily that lacks a DNA-binding domain. In previous study, we showed that SHP, c-jun, p65 of NF-kappaB subunits, and... -
- CITED
-
- Close
- SHARE
-
- Close
- Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells
-
Pae HO, Jeong GS, Jeong SO, Kim HS, Kim SA, Kim YC, Yoo SJ, Kim HD, Chung HT
- KMID: 1047077
- Exp Mol Med.
- 2007 Jun;39(3):267-277.
In vascular smooth muscle cells (VSMCs), induction of the heme oxygenase-1 (HO-1) confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) that is... -
- CITED
-
- Close
- SHARE
-
- Close
- Apoptotic Effects of Genistein, Biochanin-A and Apigenin on LNCaP and PC-3 Cells by p21 through Transcriptional Inhibition of Polo-like Kinase-1
-
Seo YJ, Kim BS, Chun SY, Park YK, Kang KS, Kwon TG
- KMID: 1123450
- J Korean Med Sci.
- 2011 Nov;26(11):1489-1494.
- doi: 10.3346/jkms.2011.26.11.1489
Natural isoflavones and flavones are important dietary factors for prostate cancer prevention. We investigated the molecular mechanism of these compounds (genistein, biochanin-A and apigenin) in PC-3 (hormone-independent/p53 mutant type) and... -
- CITED
-
- Close
- SHARE
-
- Close
- Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells
-
Jung EJ, Kim CW, Kim DR
- KMID: 756329
- Exp Mol Med.
- 2008 Jun;40(3):276-285.
- doi: 10.3858/emm.2008.40.3.276
Tropomyosin-related kinase A (TrkA) plays an important role in cell survival, differentiation, and apoptosis in various neuronal and nonneuronal cell types. Here we show that TrkA overexpression by the Tet-On... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Chromosomal Polyploidy on Survival of Colon Cancer Cells
-
Park SU, Choi ES, Jang YS, Hong SH, Kim IH, Chang DK
- KMID: 1128353
- Korean J Gastroenterol.
- 2011 Mar;57(3):150-157.
- doi: 10.4166/kjg.2011.57.3.150
BACKGROUND/AIMS: Tetraploid cells are frequently observed in the inflamed mucosal epithelial cells of the patients with Barrett's esophagus or chronic ulcerative colitis. Polyploidy often occurs during cell fusion, abortive cell... -
- CITED
-
- Close
- SHARE
-
- Close
