- Functional Inactivation of pRb Associated with Cyclin D1- and Cyclin-dependent Kinase 4 Overexpression Plays A Key Role in Human Pituitary Tumorigenesis
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Myong NH
- KMID: 1472555
- Korean J Pathol.
- 2009 Feb;43(1):56-62.
- doi: 10.4132/KoreanJPathol.2009.43.1.56
BACKGROUND: Human pituitary adenoma (PA) is a common intracranial tumor, but the mechanism underlying tumorigenesis has not been established. Functional inactivation of retinoblastoma protein (pRb) following cyclin D1- and cyclin-dependent... -
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- Expression of Cyclin D1 and CDK4 in DMBA-Induced Rat Ovarian Cancer
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Kim KK
- KMID: 2166233
- Cancer Res Treat.
- 2001 Jun;33(3):229-235.
PURPOSE: Ovarian cancer is a common gynecologic malignancy and the leading cause of death in women. It is typically not diagnosed until it has reached the advanced stages. We performed... -
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- Aberrant Cell Cycle Regulation in Cervical Carcinoma
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Kim YT, Zhao M
- KMID: 2158138
- Yonsei Med J.
- 2005 Oct;46(5):597-613.
- doi: 10.3349/ymj.2005.46.5.597
Carcinoma of the uterine cervix is one of the most common malignancies among women worldwide. Human papillomaviruses (HPV) have been identified as the major etiological factor in cervical carcinogenesis. However,... -
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- DNA Methylation in Lung Cancer
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Lee MK
- KMID: 2200226
- J Lung Cancer.
- 2002 Dec;1(1):23-28.
DNA modification in vertebrate genomes is confined to the self-complementary sequence CpG. Between 60% and 90% of CpGs are methylated at the 5 position of cytosine, and the remainder is... -
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- Expression of G1 Cell Cycle Regulators in Rat Liver upon Repeated Exposure to Thioacetamide
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Kim KT, Han SY, Jeong JS
- KMID: 760708
- Korean J Hepatol.
- 2007 Mar;13(1):81-90.
BACKGROUND/AIMS: Eukaryotic cell cycle is regulated by signal transduction pathways mediated by complexes of cyclin dependent kinases (CDKs) and their partner cyclins, or by interaction with CDK inhibitors. Thioacetamide... -
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- Role of Akt in Tumorigenesis and Angiogenesis of MC-SV-HUC T2 Cell Line
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Kim MK
- KMID: 1484901
- Korean J Anat.
- 2008 Jun;41(2):111-119.
Protein Kinase B (PKB/Akt) is a serine/threonine kinase that plays important roles in multiple physiological and pathological processes. Specially, Akt activation induces tumorigenesis in many cancers. However, molecular mechanism related... -
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- Expression of Cyclin D1, CDK4, p16 and Rb Proteins in Human Soft Tissue Sarcomas
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Yoo J, Lee AW, Kang SJ, Kim BK
- KMID: 2275610
- Korean J Pathol.
- 2001 Jun;35(3):238-244.
BACKGROUND: Altered cell cycle regulation may underlie the development and/or progression of human malignancies. The purpose of this study is to determine if the oncogenesis of soft tissue sarcomas could... -
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- Differential expression of proteins related to START checkpoint of the cell cycle in human stomach, lung, cervix and liver cancers
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Kim JR, Kim SY, Kim MJ, Kim JH
- KMID: 2045608
- Exp Mol Med.
- 1997 Jun;29(2):123-128.
START (restriction) checkpoint in late G1 of the cell cycle is important in the regulation of cell proliferation. Many tumors have shown abnormalities partly in the components such as p53,... -
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- Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles
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Rastegar H, Ashtiani H, Aghaei M, Barikbin B, Ehsani A
- KMID: 2157441
- Ann Dermatol.
- 2015 Dec;27(6):667-675.
- doi: 10.5021/ad.2015.27.6.667
BACKGROUND: The number of people suffering from balding or hair thinning is increasing, despite the advances in various medical therapies. Therefore, it is highly important to develop new therapies to... -
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- Gene Alterations of Ovarian Cancer Cells Expressing Estrogen Receptors by Estrogen and Bisphenol A Using Microarray Analysis
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Hwang KA, Park SH, Yi BR, Choi KC
- KMID: 2053658
- Lab Anim Res.
- 2011 Jun;27(2):99-107.
- doi: 10.5625/lar.2011.27.2.99
Since endocrine disrupting chemicals (EDCs) may interfere with the endocrine system(s) of our body and have an estrogenicity, we evaluated the effect(s) of bisphenol A (BPA) on the transcriptional levels... -
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- TEL(ETV 6)-AML1 Translocations with TEL and CDKN2 Inactivation in Acute Lymphoblastic Leukemia(ALL)
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Kim DH
- KMID: 1979964
- Korean J Pediatr Hematol Oncol.
- 1997 Oct;4(2):227-235.
Abnormalities of the short arm of chromosome 12 are relatively common in childhood ALL. Approximately 5~7% of children with ALL have cytogenetic evidence of a translocation involving 12p, whereas 3~5%... -
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- Expression of CDK 4, Connexin 32, and PCNA in N-diethylnitrosamine-Induced Lesions of Rat Liver
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Hur B, Kim HJ
- KMID: 1725542
- Korean J Pathol.
- 1999 May;33(5):309-318.
Cellular altered foci (CAF), hyperplastic nodules (HN) including regenerating and adenomatous nodules, and hepatocellular carcinomas (HCC) were induced in Sprague-Dawley rat liver by prolonged administration of N-diethylnitrosamine (DEN, 200 ppm).... -
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- Genetic Alterations of p16Ink4A and p15Ink4B in Gastric Carcinomas
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Hur K, Yang HK, Jang JJ, Kim JP, Kim DY
- KMID: 2059285
- J Korean Cancer Assoc.
- 1999 Oct;31(5):887-897.
PURPOSE: p16Ink4A and p15lnk4B, encoded by the genes located on chromosome 9p21, are cyclin-dependent kinase 4 inhibitors and are the upstream regulators of pRB (retinoblastoma protein) function and are involved... -
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- Differential protein expression of etoposide-treated CaSki cervical carcinoma cells
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Lee SB, Bae JS, Kim JJ, Tong SY, Yim EK, Lee KH, Kim CJ, Um SJ, Park JS
- KMID: 2143540
- Korean J Gynecol Oncol.
- 2005 Dec;16(4):333-346.
OBJECTIVE: This study was designed to examine the pharmaco-dynamic pattern of proteomic expression in cervical carcinoma cells (CaSki cell line; HPV-16 positive) after in vitro treatment by the etoposide. METHODS: We... -
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- Immunohistochemical Array for Clear Cell Type Mucoepidermoid Carcinoma
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Kim YS, Lee SS, Song JY, Kim EC, Lee SK
- KMID: 1837532
- Korean J Pathol.
- 2010 Jun;44(3):284-294.
BACKGROUND: The protein expression profile of clear cell type mucoepidermoid carcinoma (MEC) is not well known. METHODS: We examined a case of clear cell type MEC by immunohistochemical (IHC) array using... -
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- The Cytotoxic Effect of Oral Wet Wipes on Gingival Cells
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Jung IH, Park JH, Lee MK, Hwang YS
- KMID: 2411439
- J Dent Hyg Sci.
- 2018 Apr;18(2):76-84.
- doi: 10.17135/jdhs.2018.18.2.76
Wet wipes are being increasingly used because of their convenience. Particularly, oral wet wipes are useful for regular cleaning of a baby's mouth after birth. Therefore, the consumption of oral... -
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- Candidates for Tumor Markers of Cervical Cancer Discovered by Proteomic Analysis
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Song JY, Bae HS, Koo DH, Lee JK, Jung HH, Lee KW, Lee NW
- KMID: 2157970
- J Korean Med Sci.
- 2012 Dec;27(12):1479-1485.
- doi: 10.3346/jkms.2012.27.12.1479
Cervical cancer is the second most common gynecological cancer among Korean women. While nationwide screening program has developed, the pathogenesis of cervical cancer is unknown. The aim of this study... -
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