- Modulation of calcium current by cyclic GMP in the single ventricular myocytes of the rabbit
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Ahnn JH, Suh KP, Earm YE
- KMID: 1686432
- Korean J Thorac Cardiovasc Surg.
- 1992 Apr;25(4):364-382.
No abstract available. -
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- Effect of Cyclic GMP on Human Cytomegalovirus Gene Expression
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Yoon JH, Lee GC, Song BH, Kim YJ, Lee CH
- KMID: 1544232
- J Korean Soc Virol.
- 1999 Dec;29(4):261-269.
No abstract available. -
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- Effects of calcium antagonists on contractions of chorionic arteries in normal and preeclampsia placenta
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Kook H, Yoon YD, Baik YH
- KMID: 644958
- J Korean Med Sci.
- 1996 Jun;11(3):250-257.
- doi: 10.3346/jkms.1996.11.3.250
This study was undertaken to observe the effects of organic or inorganic calcium antagonists and to investigate the involvement of cyclic nucleotides in regulating the vascular tone in the chorionic... -
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- Study on Contractile Responses Induced by Anoxia in Porcine Cerebral Artery
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Ko JS, Kang SS, Baik YH
- KMID: 2068043
- J Korean Neurosurg Soc.
- 1995 Jun;24(6):623-630.
This study was designed to observe anoxia-induced responses and to clarify their possible mechanisms in porcine basilar and circle of Willis arteries. Anoxia produced a transient vasoconstriction, which then recovered... -
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- Potentiating Effects of Bay K 8644 on the Relaxation Induced by Ultraviolet or Visible Light in Porcine Coronary Artery
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Kook H, Baik YH, Kang JC, Chae SW
- KMID: 2093567
- Korean Circ J.
- 1996 Feb;26(1):78-87.
- doi: 10.4070/kcj.1996.26.1.78
BACKGROUND: This study was aimed at defining the varying responses of porcine coronary artery(PCA) to various wavelengths of ultraviolet irradiation, and at relating them to the changes in cyclic GMP... -
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- Regulatory role of cyclic nucleotides in non-adrenergic non-cholinergic relaxation of lower esophageal sphincter from dogs
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Kim YT, Rhim BY
- KMID: 2285174
- Korean J Physiol Pharmacol.
- 1997 Jun;1(3):303-313.
The role of the lower esophageal sphincter (LES) is characterized by the ability to maintain tone and to relax allowing the passage of a bolus. It is known that LES relaxation during... -
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- Involvement of Spontaneously Formed Cyclic Nucleotides in Cat Gastric Muscle Relaxation
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Sim SS, Baek HJ, Rhie DJ, Yoon SH, Hahn SJ, Jo YH, Kim MS
- KMID: 2285221
- Korean J Physiol Pharmacol.
- 1999 Jun;3(3):275-282.
Muscle strips and muscle cells from cat stomach were used to investigate whether spontaneously formed cyclic nucleotides were involved in the inhibition of gastric smooth muscle contraction. A phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine (IBMX), increased the... -
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- Effects of Adenosine Triphosphate on Relaxation of Rabbit Cavernosal Smooth Muscle
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Park HS, Kim JJ
- KMID: 2289723
- Korean J Urol.
- 1994 Aug;35(8):846-851.
Externally applied acetylcholine(Ach) in corpus cavernosum has been shown to cause endothelium dependent smooth muscle relaxation. ATP is accepted as a relaxant of smooth muscle by both a direct action... -
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- A Study of Vascular Relaxation Mechanism of GS-389, a New Potent Vasodilator
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Yum MK, Chang KC, Yun YS
- KMID: 2228994
- Korean Circ J.
- 1991 Dec;21(6):1111-1125.
- doi: 10.4070/kcj.1991.21.6.1111
The mechanism of vasodilation effect of GS-389, 1-(4'-methoxybenzyl)-6,7 -dimethoxy-1,2,3,4-tetrhydroisoquinoline hydrocholoride, a possible cyclic GMP specific phosphodiesterase inhibitor, on rat and mouse thoracic aorta ring has been investigated. GS-389 relaxed rat... -
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- Past, Present and Future of PDE5 Inhibitor
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Kim JJ, Moon DG
- KMID: 2226569
- Korean J Androl.
- 2008 Jun;26(2):49-60.
The phosphodiesterase type-5 inhibitors (PDE5-Is) sildenafil, vardenafil and tadalafil are widely used as first-line therapy for erectile dysfunction (ED). Since the approval of sildenafil in 1998, more than 40 million... -
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- New Frontiers in Pharmacology
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Lee WC
- KMID: 687775
- Yonsei Med J.
- 1979 Dec;20(2):87-91.
- doi: 10.3349/ymj.1979.20.2.87
No abstract available. -
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- Effect of Amiloride to Retinal Toxicity Induced by Tissue Plasminogen Activator
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Kim US, Oh HS, Kwon OW, Chung I, Lee SH, Lee JH
- KMID: 1397489
- Korean J Ophthalmol.
- 2012 Oct;26(5):378-382.
- doi: 10.3341/kjo.2012.26.5.378
PURPOSE: The effects of amiloride on cellular toxicity caused by tissue plasminogen activator (tPA) in mouse primary retinal cells were investigated. METHODS: Primary retinal cell cultures were maintained using glial conditioned... -
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- Endothelial Dysfunction and Alteration of Nitric Oxide/ Cyclic GMP Pathway in Patients with Exercise-Induced Hypertension
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Chang HJ, Chung JH, Choi BJ, Choi TY, Choi SY, Yoon MH, Hwang GS, Shin JH, Tahk SJ, Choi BI
- KMID: 1091042
- Yonsei Med J.
- 2003 Dec;44(6):1014-1020.
- doi: 10.3349/ymj.2003.44.6.1014
The diagnostic and prognostic implication of exaggerated blood pressure response to exercise have been controversial, with opinions ranging from a benign process to a harbinger of potential cardiovascular morbidity. Endothelial... -
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- Effect of Nitric Oxide on Penile Erection in Rats
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Jang TG, Suh JK
- KMID: 1662198
- Korean J Urol.
- 1995 Apr;36(4):377-385.
Nitric oxide (NO) is known to have a strong relaxant effect in various biological organs including blood vessels and corpus cavernosum. The goal of the present study was to investigate... -
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- Alteration of Nitric Oxide/cyclic-GMP pathway in patients with exaggerated systolic blood pressure response during exercise test
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Park IW, Chang HJ, Chung J, Shin JH, Choi TY, Choi SY, Yoon MH, Hwang GS, Tahk SJ, Choi BI
- KMID: 1833205
- Korean J Med.
- 2003 Jul;65(1):90-98.
BACKGROUND: The diagnostic and prognostic implication of exaggerated blood pressure response to exercise has not been well characterized. Endothelial dysfunction has been demonstrated in patients with atherosclerosis or with risk... -
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- Effect of NG-nitro-L-arginine methyl ester and Methylene Blue on the Endotoxin-induced Vascular Hyporesponsiveness
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Choi HC, Ha JH, Lee KY, Kim WJ, Sohn UD
- KMID: 2320331
- Yeungnam Univ J Med.
- 1997 Dec;14(2):337-349.
The study was undertaken to examine the intensity of involvement of inducible nitric oxide synthase(iNOS) and cyclic GMP signal transduction pathway as one of the mechanisms of vaso-relaxative action of... -
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- Effect of Nitric Oxide Donor on Penile Erection in Rats
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Jeon WS, Park TC, Suh JK
- KMID: 2290101
- Korean J Urol.
- 1997 Sep;38(9):931-938.
Nitric oxide (NO) is known to mediate penile erection by activating intracellular cyclic GMP pathway. It is also suggested that cGMP pathway, on penile erection, has dominant role over the... -
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- Effect and Mechanism of Phosphodiesterase Inhibitors on Trabecular Outflow
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Kim JW, Lee JB, Lee SH
- KMID: 2459522
- Korean J Ophthalmol.
- 2019 Oct;33(5):414-421.
- doi: 10.3341/kjo.2019.0057
PURPOSE: Phosphodiesterase (PDE) inhibitors increase matrix metalloproteinase (MMP) production by inhibiting re-uptake of adenosine and may potentiate nitric oxide (NO) activity. This study was performed to investigate the effects and... -
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- The hyperthermic effect of nitric oxide in central nervous system
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Jung JK, Sohn UD, Lee SY
- KMID: 1606844
- Korean J Physiol Pharmacol.
- 2001 Feb;5(1):93-98.
The precise mechanism of set-point regulation in hypothalamus was not elucidated. Nitric oxide synthases (NOS) were detected in hypothalamus, however, the roles of NO in hypothalamus was not fully studied. So, we tested... -
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- Nitric Oxide-Induced Intracellular Ca2+ Modulation in Macrovascular Endothelial Cells
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Jeon SH, Seol GH, Suh SH, Park SH
- KMID: 1858910
- Korean Circ J.
- 2004 Jun;34(6):600-609.
- doi: 10.4070/kcj.2004.34.6.600
BACKGROUND AND OBJECTIVES: Nitric oxide (NO) reduces the intracellular Ca2+ concentration ([Ca2+]i) in smooth muscle cells, whereas the effect of NO on [Ca2+]i in endothelial cells is still controversial. Therefore,... -
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