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Lotus (Nelumbo nuficera) flower essential oil increased melanogenesis in normal human melanocytes

Jeon S, Kim NH, Koo BS, Kim JY, Lee AY

In this study, the essential oil from lotus flower extract, including petals and stamens, was assessed with regard to its effects on melanogenesis in human melanocytes. The lotus flower essential...
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Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration

Jeon S, Kim NH, Koo BS, Lee HJ, Lee AY

  • KMID: 1090963
  • Exp Mol Med.
  • 2007 Oct;39(5):603-613.
Pigmentation may result from melanocyte proliferation, melanogenesis, migration or increases in dendricity. Recently, it has been reported that secreted phospholipase A2(sPLA2) known as a component of bee venom (BV), stimulates...
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Inhibition of gamma ray-induced apoptosis by stimulatory heterotrimeric GTP binding protein involves Bcl-xL down-regulation in SH-SY5Y human neuroblastoma cells

Kim SY, Seo M, Oh JM, Cho EA, Juhnn YS

  • KMID: 1090961
  • Exp Mol Med.
  • 2007 Oct;39(5):583-593.
Heterotrimeric GTP-binding proteins (G proteins) transduce extracellular signals into intracellular signals by activating effector molecules including adenylate cyclases that catalyze cAMP formation, and thus regulate various cellular responses such as...
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In Vitro and In Vivo Effect of Parathyroid Hormone Analogue (1-14) Containing alpha-amino-iso-butyric Acid Residue (Aib)1,3

Rhee Y, Lee W, Lee EJ, Ma S, Park SY, Lim SK

Firstly, parathyroid hormone (1-14) [PTH (1-14)] analogue containing various alpha-amino-iso-butyric acid residue (Aib) was synthesized by exchanging the 1st and 3rd Ala residues of alpha carbon of PTH (1-14). This...
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Inhibitory effects of epigallocatechin gallate on compound 48/80-inducedmast cell activation and passive cutaneous anaphylaxis

Li GZ, Chai OH, Song CH

  • KMID: 1093464
  • Exp Mol Med.
  • 2005 Aug;37(4):290-296.
Epigallocatechin gallate (EGCG) is a principle phenolic antioxidant found in a variety of plants, including green and black tea. The anti-allergic effect of EGCG is unknown. The purpose of this...
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Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells

Namkoong S, Lee SJ, Kim CK, Kim YM, Chung HT, Lee H, Han JA, Ha KS, Kwon YG, Kim YM

  • KMID: 1116204
  • Exp Mol Med.
  • 2005 Dec;37(6):588-600.
Prostaglandin E2(PGE2), a major product of cyclooxygenase, has been implicated in modulating angiogenesis, vascular function, and inflammatory processes, but the underlying mechanism is not clearly elucidated. We here investigated the...
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Structure and Function of a Minimal Receptor Activation Domain of Parathyroid Hormone

Lee EJ, Kim HY, Cho MK, Lee W, Lim SK

The structure and function of short-length amino terminal PTH analogues were studied. The substitution of Leu7 with Phe in [Ala3, 10Leu7Arg11]rPTH (1-11) NH2 analogue peptides did not show any reduction...
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Theophylline Increases the Uptake of Radioiodine by Mouse Thyroid

Lee JM, Caturegli , Ladenson P

Diagnostic and therapeutic use of radioiodine in the management of thyroid disorders depends on the ability of thyroid cells to concentrate radioiodine, a process that is regulated by the intracellular...
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Overexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells

Kim SY, Ghil SH, Kim SS, Myeong HH, Lee YD, Suh-Kim HY

  • KMID: 1121101
  • Exp Mol Med.
  • 2002 Dec;34(6):469-475.
Neurogenin1 (Ngn1) is a basic helix-loop-helix (bHLH) transcription factor expressed in neuronal precursors in the developing nervous system. The function of Ngn1 in neurogenesis has been shown in various...
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Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase

Marunaka Y, Niisato N, Ito Y

1) A beta agonist stimulated Na+ transport and decreased the intracellular Cl concentration ([Cl]c) associated with cell shrinkage via an increase in cytosolic cAMP level by activating adenylate cyclase in...
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A novel Na+-dependent transporter and NHE3 mediate H+ efflux in the luminal membrane of the pancreatic duct: regulation by cAMP

Lee MG, Ahn W, Choi JY, Muallem S, Kim KH

No abstract available.
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Effect of cilostazol on the neuropathies of streptozotocin-induced diabetic rats

Suh KS, Oh SJ, Woo JT, Kim SW, Yang IM, Kim JW, Kim YS, Choi YK, Park IK

  • KMID: 760332
  • Korean J Intern Med.
  • 1999 Jul;14(2):34-40.
OBJECTIVES: This study examined the effect of cilostazol, a potent phosphodiesterase inhibitor, on the progression of neuropathies associated with streptozotocin-induced diabetes mellitus in Sprague-Dawley rats. METHODS: Eight ...
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Development of two novel nontoxic mutants of Escherichia coli heat-labile enterotoxin

Park EJ, Chang JH, Kim JS, Chung SI, Yum JS

  • KMID: 1029939
  • Exp Mol Med.
  • 1999 Jun;31(2):101-107.
Escherichia coli heat-labile enterotoxin (LT) is composed of catalytic A and non-catalytic homo-pentameric B subunits and causes diarrheal disease in human and animals. In order to produce a nontoxic LT for vaccine...
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Effect of adenylate cyclase inhibitor and protein kinase C inhibitor on GnRH-induced LH release and LH beta subunit biosynthesis in rat anterior pituitary cells

Kim C, Park D, Ryu K

According to our previous studies together with others, GnRH, a hypothalamic decapeptide, has been known to be a major regulator for LH release and its subunit biosynthesis in anterior pituitary...
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New Frontiers in Pharmacology

Lee WC

No abstract available.
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