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Mechanisms of Cross-protection by Influenza Virus M2-based Vaccines

Lee YN, Kim MC, Lee YT, Kim YJ, Kang SM

Current influenza virus vaccines are based on strain-specific surface glycoprotein hemagglutinin (HA) antigens and effective only when the predicted vaccine strains and circulating viruses are well-matched. The current strategy of...
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Development and evaluation of protective capacity of Salmonella Enteritidis polyphosphate kinase-deleted and temperature-sensitive mutant

Kim K, Park S, Cho Y, Kwak JY, Kang ZW, Kim EH, Choi HW, Won HK, Noh YH, Hahn TW

  • KMID: 1790567
  • Korean J Vet Res.
  • 2013 Dec;53(4):211-216.
This study was focusing on evaluating the protection of polyphosphate kinase (ppk) deleted and/or temperature-sensitive (ts) Salmonella Enteritidis (SE) as an attenuated vaccine in chickens. We constructed SEppk, SEts and...
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Cross-Protective Immune Responses Elicited by Live Attenuated Influenza Vaccines

Jang YH, Seong BL

The desired effect of vaccination is to elicit protective immune responses against infection with pathogenic agents. An inactivated influenza vaccine is able to induce the neutralizing antibodies directed primarily against...
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Protection Against Salmonella Typhimurium, Salmonella Gallinarum, and Salmonella Enteritidis Infection in Layer Chickens Conferred by a Live Attenuated Salmonella Typhimurium Strain

Lee JH

In the present study, we investigated the protection conferred by a live attenuated Salmonella enterica serovar Typhimurium (ST) strain against Salmonella Typhimurium, Salmonella Gallinarum (SG), and Salmonella Enteritidis (SE) infection...
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Efficacy of human papillomavirus vaccines including cross protection : A review of recent evidence

Kim CJ, Park TC, Park JS

The efficacy and immunogenicity of human papillomavirus (HPV) vaccines has proven excellent in several phase 2 and phase 3 trials involving tens of thousand women. Two versions of HPV vaccine...
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Cross-reaction of 6B and 19F Specific Antibodies to Serotypes 6A, 6C, and 19A after Immunization with 7-valent Pneumococcal Conjugate Vaccine in Korean Children Aged 12-23 Months

Kim KH, Yang JY, Park IH, Lim SY

  • KMID: 2279010
  • Korean J Pediatr Infect Dis.
  • 2013 Aug;20(2):53-62.
PURPOSE: The cross-protection of 7-valent pneumococcal conjugate vaccine (PCV7) against vaccine-related serotypes has been controversial. We investigated the serological properties of cross-protective antibodies against vaccine-related serotypes 6A, 6C, and 19A...
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A novel M2e-multiple antigenic peptide providing heterologous protection in mice

Wen F, Ma JH, Yu H, Yang FR, Huang M, Zhou YJ, Li ZJ, Wang XH, Li GX, Jiang YF, Tong W, Tong GZ

Swine influenza viruses (SwIVs) cause considerable morbidity and mortality in domestic pigs, resulting in a significant economic burden. Moreover, pigs have been considered to be a possible mixing vessel in...
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Principles underlying rational design of live attenuated influenza vaccines

Jang YH, Seong BL

Despite recent innovative advances in molecular virology and the developments of vaccines, influenza virus remains a serious burden for human health. Vaccination has been considered a primary countermeasure for prevention...
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