- Control of Scarring in Adult Wounds using Antisense Connective Tissue Growth Factor Ollgodeoxynucleotides
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Chung HT
- KMID: 1550742
- Korean J Immunol.
- 1999 Dec;21(4):311-317.
Adult wounds heal with scar formation, whereas fetal wounds heal without scarring and with a lesser inflammatory and cytokine response. Recently connective tissue growth factor (CTGF) is known to play... -
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- Biological roles of insulin-like growth factor binding proteins (IGFBPs)
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Kim HS, Rosenfeld , Oh YM
- KMID: 2045603
- Exp Mol Med.
- 1997 Jun;29(2):85-96.
The insulin-like growth factor binding protein (IGFBP) family is a critical component of the insulin-like growth factor (IGF) system which regulate the biological actions of the IGFs and may also... -
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- The Role and Relation of VEGF, TGF-beta1 and CTGF in the Scar Formation of the Rat
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Jeon DW, Kim JY, Han SM, Noh HJ, Han KH, Park KK
- KMID: 2119900
- J Korean Soc Plast Reconstr Surg.
- 2004 Jan;31(1):110-118.
Skin fibrotic disorders are understood to develop under the influence of various cytokines, such as transforming growth factor(TGF)-beta1, connective tissue growth factor(CTGF) and vascular endothelial growth factor (VEGF). To establish... -
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- The Role of CTGF in Osteosarcoma Progression
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Han I, Lee MR, Kim HS
- KMID: 1707758
- J Korean Bone Joint Tumor Soc.
- 2014 Jun;20(1):1-6.
- doi: 10.5292/jkbjts.2014.20.1.1
PURPOSE: To examine the expression of Connective Tissue Growth Factor (CTGF) in osteosarcoma and to evaluate its role in osteosarcoma invasion and proliferation. MATERIALS AND METHODS: The mRNA expression of CTGF... -
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- The Effect of Preoperative Subconjunctival Injection of Mitomycin C and Triamcinolone in Recurrent Pterygium
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Oh JH, Kim HK
- KMID: 2212487
- J Korean Ophthalmol Soc.
- 2009 Jul;50(7):1005-1014.
- doi: 10.3341/jkos.2009.50.7.1005
PURPOSE: To evaluate the effect of a preoperative subconjunctival injection of mitomycin C or triamcinolone in patients with recurrent pterygium. METHODS: The records of 50 eyes of 50 patients who... -
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- Connective Tissue Growth Factor Neutralization Aggravates the Psoriasis Skin Lesion: The Analysis of Psoriasis Model Mice and Patients
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Hayakawa K, Ikeda K, Fujishiro , Yoshida Y, Hirai T, Tsushima H, Miyashita , Morimoto S, Suga Y, Takamori K, Ogawa H, Sekigawa I
- KMID: 2399754
- Ann Dermatol.
- 2018 Feb;30(1):47-53.
- doi: 10.5021/ad.2018.30.1.47
BACKGROUND: Connective tissue growth factor (CTGF) is a multifunctional cellular protein and playing a role as a central mediator in tissue remodeling and fibrosis. The physiological function of CTGF in... -
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- Inhibition of Fibrotic Contraction by C-Phycocyanin through Modulation of Connective Tissue Growth Factor and α-Smooth Muscle Actin Expression
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An E, Park H, Lee AR
- KMID: 2382938
- Tissue Eng Regen Med.
- 2016 Aug;13(4):388-395.
- doi: 10.1007/s13770-015-0104-5
The effects of C-phycocyanin (C-pc), a phycobiliprotein, on the expression of pro-fibrotic mediators in hyper-tropic scarring such as connective tissue growth factor (CTGF) and α-smooth muscle actins (α-SMA) were investigated... -
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- Expression of growth factor, extracellular matrix and antioxidant (N-acetylcysteine) effect in TGF beta1 treated rat lens system
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Park MS, Ahn CS, Hong YS
- KMID: 2206311
- J Korean Ophthalmol Soc.
- 2002 Dec;43(12):2543-2554.
PURPOSE: The objective of this study was to characterize transdifferentiated lens epithelial cells analyzed by reverse transcription-polymerase chain reaction (RT-PCR) for the expression of mRNAs encoding growth factors, growth factor... -
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- Hypoxia Induces the Expression of Connective Tissue Growth Factor in Dermal Fibroblasts
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Hong KH, Yoo SA, Kang SS, Shin YJ, Kim WU, Cho CS
- KMID: 2202327
- J Korean Rheum Assoc.
- 2004 Dec;11(4):387-397.
OBJECTIVE: Connective tissue growth factor (CTGF) has been proposed to play a role in fibrotic process of systemic sclerosis. Since hypoxia was known to be associated with fibrosis in several... -
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- Local Silencing of Connective Tissue Growth Factor by siRNA/Peptide Improves Dermal Collagen Arrangements
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Cho Lee AR, Woo I
- KMID: 2441263
- Tissue Eng Regen Med.
- 2018 Dec;15(6):711-719.
- doi: 10.1007/s13770-018-0166-2
BACKGROUND: Collagen organization within tissues has a critical role in wound regeneration. Collagen fibril diameter, arrangements and maturity between connective tissue growth factor (CTGF) small interfering RNA (siRNA) and mismatch... -
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- Antifibrotic Effects of Phosphodiesterase (PDE) Inhibitor in Experimental Interstitial Fibrosis induced by Unilateral Ureteral Obstruction
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Ha IS, Um EY, Kang HG, Hahn HW, Park HW, Cheong HI, Choi Y
- KMID: 2116640
- J Korean Soc Pediatr Nephrol.
- 2002 Apr;6(1):85-91.
PURPOSE: Phosphodiesterase (PDE) inhibitor increases the cellular content of cAMP, and cAMP suppresses connective tissue growth factor (CTGF) expression induced by TGF-beta1. Therefore, we investigated whether PDE inhibitor suppresses renal... -
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- Fluvastatin inhibits advanced glycation end products-induced proliferation, migration, and extracellular matrix accumulation in vascular smooth muscle cells by targeting connective tissue growth factor
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Hwang AR, Nam JO, Kang YJ
- KMID: 2410109
- Korean J Physiol Pharmacol.
- 2018 Mar;22(2):193-201.
- doi: 10.4196/kjpp.2018.22.2.193
Connective tissue growth factor (CTGF) is a novel fibrotic mediator, which is considered to mediate fibrosis through extracellular matrix (ECM) synthesis in diabetic cardiovascular complications. Statins have significant immunomodulatory effects... -
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- Hypoxia Induces Connective Tissue Growth Factor mRNA Expression
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Lee YK, Kim EJ, Lee JE, Noh JW, Kim YG
- KMID: 1778159
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S176-S182.
- doi: 10.3346/jkms.2009.24.S1.S176
Connective tissue growth factor (CTGF) is known to be a profibrotic growth factor, which mediate the fibrotic effect of transforming growth factor-beta(TGF-beta) and to stimulate cell proliferation and matrix production.... -
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- Hypoxia Induces Connective Tissue Growth Factor (CTGF) in Cultured Tubular Cells
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Lee YK, Kim EJ, Kim YO, Kim HJ, Lee JE, Huh WS, Kim DJ, Noh JW, Oh HY, Kim YG
- KMID: 2307233
- Korean J Nephrol.
- 2005 Sep;24(5):729-738.
BACKGROUND: Connective tissue growth factor (CTGF) is demonstrated to mediate the fibrotic effect of TGF-beta1 and to stimulate cell proliferation and matrix production. In the present study, we examined the... -
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- Local Delivery of CTGF siRNA with Poly(sorbitol-co-PEI) Reduces Scar Contraction in Cutaneous Wound Healing
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Cho KH, Singh B, Maharjan1 , Jang Y, Choi YJ, Cho CS
- KMID: 2395078
- Tissue Eng Regen Med.
- 2017 Jun;14(3):211-220.
- doi: 10.1007/s13770-017-0059-9
Healing process in scarring inevitably produces a considerable amount of non-organized dense collagen-rich matrix called scar thus impairing the native structure of skin. Connective tissue growth factor (CTGF) overexpression within... -
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- Reduced Expression of YAP in Dermal Fibroblasts is Associated with Impaired Wound Healing in Type 2 Diabetic Mice
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Yu J, Choi S, Um J, Park KS
- KMID: 2371103
- Tissue Eng Regen Med.
- 2017 Feb;14(1):49-55.
- doi: 10.1007/s13770-016-0019-9
Dermal fibroblasts play essential roles in wound healing and their dysfunction has been shown to be associated with impaired wound healing in diabetes. In the present study, we aimed at... -
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- High Glucose Induces Connective Tissue Growth Factor Expression and Extracellular Matrix Accumulation in Rat Aorta Vascular Smooth Muscle Cells Via Extracellular Signal-Regulated Kinase 1/2
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Ha YM, Lee DH, Kim M, Kang YJ
- KMID: 2285465
- Korean J Physiol Pharmacol.
- 2013 Aug;17(4):307-314.
- doi: 10.4196/kjpp.2013.17.4.307
Connective tissue growth factor (CTGF) is a potent pro-fibrotic factor, which is implicated in fibrosis through extracellular matrix (ECM) induction in diabetic cardiovascular complications. It is an important downstream mediator... -
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- Calcitonin induces connective tissue growth factor through ERK1/2 signaling in renal tubular cells
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Nakamura M, Ozaki T, Ishii A, Konishi M, Tsubota Y, Furui T, Tsuda H, Mori I, Ota K, Kakudo K
- KMID: 1123804
- Exp Mol Med.
- 2009 May;41(5):307-314.
- doi: 10.3858/emm.2009.41.5.034
Calcitonin (CT), a polypeptide hormone, plays important roles in a variety of physiological processes. CT has been used clinically to treat osteoporosis and humoral hypercalcemia of malignancy. In order to... -
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- A Simple, Quantitative Method for Assessing Angiogenic Genes Using Skeletal Muscle by Electroporation-Mediated Naked DNA Delivery
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Kim HJ, Jang HS, Kim JM, Lee YS, Kim KR, Kim JA, Jeon ES, Byun JH, Kim DK
- KMID: 2093869
- Korean Circ J.
- 2003 Apr;33(4):321-332.
- doi: 10.4070/kcj.2003.33.4.321
BACKGROUND AND OBJECTIVES: For the development of an arteriogenic gene therapy in peripheral artery occlusive disease, we developed a novel angiogenesis assay, with electroporation-mediated naked DNA delivery to the skeletal... -
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- Regulatory Mechanism of MicroRNA-145 in the Pathogenesis of Acute Aortic Dissection
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Li T, Liu C, Liu L, Xia H, Xiao Y, Wang X, Wang Y
- KMID: 2450190
- Yonsei Med J.
- 2019 Apr;60(4):352-359.
- doi: 10.3349/ymj.2019.60.4.352
PURPOSE: Previous studies have confirmed that microRNAs play important roles in the pathogenesis of acute aortic dissection (AAD). Here, we aimed to explore the role of miR-145 and its regulatory... -
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