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Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro

Lim HC, Kim YG, Lim JH, Kim HS, Park H

PURPOSE: Itopride hydrochloride (itopride) inhibits acetylcholinesterase (AChE) and antagonizes dopamine D(2) receptor, and has been used as a gastroprokinetic agent. However, its prokinetic effect on the small bowel or colon...
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Effects of Tamoxifen on the Voltage-dependent Ionic Currents in Mouse Colonic Smooth Muscle Cells

Lee DM, Chang SJ, Park CG, Kim MW, Lim GH, Choi S, Yeum CH, Yoon PJ, Jun JY

  • KMID: 772862
  • Korean J Gastroenterol.
  • 2005 Nov;46(5):388-395.
BACKGROUND/AIMS: Tamoxifen is a widely used anticancer drug for breast cancer with frequent gastrointestinal side effects. Changes in gastrointestinal motility is associated with altered activities of membrane ion channels....
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The Effect of Urocortin 1 on Motility in Isolated, Vascularly Perfused Rat Colon

You IY, Lee S, Kim KB, Lee HS, Jang JS, Yeon M, Han JH, Yoon SM, Chae HB, Park SM, Youn SJ

BACKGROUND/AIMS: Urocortin 1, a corticotropin-releasing factor related peptide, increases colonic motility under stressful conditions. We investigated the effect of urocortin 1 on colonic motility using an experimental model with isolated...
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