- CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells
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Kim EJ, Kang KH, Ju JH
- KMID: 2365977
- Korean J Intern Med.
- 2017 Jan;32(1):42-61.
- doi: 10.3904/kjim.2016.198
Recent advances in genome editing with programmable nucleases have opened up new avenues for multiple applications, from basic research to clinical therapy. The ease of use of the technology—and particularly... -
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- Applications of kidney organoids derived from human pluripotent stem cells
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Kim YK, Nam SA, Yang CW
- KMID: 2415990
- Korean J Intern Med.
- 2018 Jul;33(4):649-659.
- doi: 10.3904/kjim.2018.198
The establishment of protocols to differentiate kidney organoids from human pluripotent stem cells provides potential applications of kidney organoids in regenerative medicine. Modeling of renal diseases, drug screening, nephrotoxicity testing... -
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- Application of CRISPR/Cas9 in Treating Hepatitis B Virus
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Cho JY
- KMID: 2396565
- J Liver Cancer.
- 2017 Sep;17(2):111-116.
- doi: 10.17998/jlc.17.2.111
The advent of oral antiviral agents has revolutionized hepatitis B treatment. It has led to decreased incidence and mortality related to hepatocellular carcinoma. However, although nucleos(t)ide analogs (NA) are fast... -
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- Effects of clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) protein 9 system-Based Deletion of miR-451 in Mouse Embryonic Stem Cells on Their Self-Renewal and Hematopoietic Differentiation
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Kim SJ, Kim CH, An B, Ha KS, Hong SH, Kim KS
- KMID: 2377348
- Tissue Eng Regen Med.
- 2017 Apr;14(2):179-185.
- doi: 10.1007/s13770-017-0031-8
Pluripotent stem cells (PSCs) are a useful source of cells for exploring the role of genes related with early developmental processes and specific diseases due to their ability to differentiate... -
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- Genome Editing Using Engineered Nucleases
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Shin JH, Kim H
- KMID: 2162812
- J Korean Orthop Res Soc.
- 2015 Dec;18(2):60-73.
- doi: 10.0000/jkors.2015.18.2.60
Genome editing is a useful research tool essentially applicable to gene therapy in the field of biotechnology, pharmaceutics and medicine. Scientists have developed three types of programmable nucleases for genome... -
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- Protocatechuic Aldehyde Represses Proliferation and Migration of Breast Cancer Cells through Targeting C-terminal Binding Protein 1
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Deng Y, Guo W, Li G, Li S, Li H, Li X, Niu B, Song M, Zhang Y, Xu Z, Li F
- KMID: 2470879
- J Breast Cancer.
- 2020 Feb;23(1):20-35.
- doi: 10.4048/jbc.2020.23.e7
PURPOSE: C-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor that is overexpressed in many cancers. CtBP1 transcriptionally represses a broad array of tumor suppressors, which promotes cancer cell proliferation,... -
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- PF-04620110, a Potent Antidiabetic Agent, Suppresses Fatty Acid-Induced NLRP3 Inflammasome Activation in Macrophages
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Jo SI, Bae JH, Kim SJ, Lee JM, Jeong JH, Moon JS
- KMID: 2460961
- Diabetes Metab J.
- 2019 Oct;43(5):683-699.
- doi: 10.4093/dmj.2019.0112
BACKGROUND: Chronic inflammation has been linked to insulin resistance and type 2 diabetes mellitus (T2DM). High-fat diet (HFD)-derived fatty acid is associated with the activation of chronic inflammation in T2DM.... -
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