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Successful birth with preimplantation genetic diagnosis using single-cell allele-specific PCR and sequencing in a woman with hypochondroplasia due to FGFR3 mutation (c.1620C>A, p.N540K)

Park KE, Kim SA, Kang MJ, Kim HS, Cho SI, Yoo KW, Kim SY, Lee HJ, Oh SK, Seong MW, Ku SY, Jun JK, Park SS, Choi YM, Moon SY

Hypochondroplasia (HCH) is an autosomal dominant inherited skeletal dysplasia, usually caused by a heterozygous mutation in the fibroblast growth factor receptor 3 gene (FGFR3). A 27-year-old HCH woman with a...
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Ovarian stimulation and liver dysfunction: Is a clinical relationship possible? A case of hepatic failure after repeated cycles of ovarian stimulation

Giugliano , Cagnazzo E, Pansini G, Vesce F, Marci R

Liver damage induced by ovarian stimulation has been demonstrated in some cases reported in the literature. However, there has never been a fruitful debate on this topic. The present manuscript...
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Autophagy-related protein LC3 and Beclin-1 in the first trimester of pregnancy

Chifenti B, Locci MT, Lazzeri G, Guagnozzi , Dinucci D, Chiellini , Filice ME, Salerno MG, Battini L

Autophagy is a degradation process that acts in response to environmental stressors. Recently, autophagy has been detected in normal term, preeclamptic and intrauterine growth-restricted placentas. The object of this work...
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Natural conception rate following laparoscopic surgery in infertile women with endometriosis

Lee HJ, Lee JE, Ku SY, Kim SH, Kim JG, Moon SY, Choi YM

OBJECTIVE: To investigate the influence of laparoscopic surgery on the natural conception rate in infertile women with endometriosis during the first year after the operation. METHODS: We retrospectively studied 43 infertile...
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The utility of sperm DNA damage assay using toluidine blue and aniline blue staining in routine semen analysis

Kim HS, Kang MJ, Kim SA, Oh SK, Kim H, Ku SY, Kim SH, Moon SY, Choi YM

OBJECTIVE: The aim of the present study was to examine the relationship among male age, strict morphology, and sperm chromatin structure and condensation. METHODS: Sperm samples from a total of 100...
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Altered expression of norepinephrine transporter and norepinephrine in human placenta cause pre-eclampsia through regulated trophoblast invasion

Na KH, Choi JH, Kim CH, Kim KS, Kim GJ

OBJECTIVE: We investigated the norepinephrine transporter (NET) expression in normal and pre-eclamptic placentas and analyzed the invasion activity of trophoblastic cells based on norepinephrine (NE)-NET regulation. METHODS: NET and NE expression...
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Fertilization and pregnancy potential of immature oocytes from stimulated intracytoplasmic sperm injection cycles

Shin SB, Cho JW, Lee SH, Yang KM, Lim CK, Lee HS

OBJECTIVE: We evaluated the fertilization potential of immature oocytes obtained from controlled ovarian hyperstimulation cycles of patients undergoing ICSI. METHODS: We retrospectively analyzed 463 ICSI cycles containing at least one immature...
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Nuclear localization of Obox4 is dependent on its homeobox domain

Park GT, Lee KA

OBJECTIVE: Oocyte-specific homeobox 4 (Obox4) is preferentially expressed in oocytes and plays an important role in the completion of meiosis of oocytes. However, the Obox4 expression pattern has not been...
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