- Trends of clinical trials from 2014 to 2016 in South Korea
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Huh KY, Hwang JG, Lee S
- KMID: 2429513
- Transl Clin Pharmacol.
- 2018 Dec;26(4):172-176.
- doi: 10.12793/tcp.2018.26.4.172
Mandatory registration of clinical trials in public registry can ensure the transparency of clinical trials. Public clinical trial registry of can provide current chronological and geographical distribution of clinical trial... -
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- Targeted Cancer Therapy Using Engineered Salmonella typhimurium
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Zheng JH, Min JJ
- KMID: 2432267
- Chonnam Med J.
- 2016 Sep;52(3):173-184.
- doi: 10.4068/cmj.2016.52.3.173
Obligate or facultative anaerobic bacteria such as Bifidobacterium, Clostridium, Salmonella, or Escherichia coli specifically colonize and proliferate inside tumor tissues and inhibit tumor growth. Among them, attenuated Salmonella typhimurium (S.... -
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- Assessment of statistical power for covariate effects in data from phase I clinical trials
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Kim Y, Son H, Son M, Lee D, Heo YA, Park K
- KMID: 2148857
- Transl Clin Pharmacol.
- 2015 Jun;23(1):31-34.
- doi: 10.12793/tcp.2015.23.1.31
One of the important purposes in population pharmacokinetic studies is to investigate the relationships between parameters and covariates to describe parameter variability. The purpose of this study is to evaluate... -
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- Use of Molecular Imaging in Clinical Drug Development: a Systematic Review
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Son H, Jang K, Lee H, Kim SE, Kang KW, Lee H
- KMID: 2450011
- Nucl Med Mol Imaging.
- 2019 Jun;53(3):208-215.
- doi: 10.1007/s13139-019-00593-y
BACKGROUND: Molecular imaging such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) can provide the crucial pharmacokinetic-pharmacodynamic information of a drug non-invasively at an early stage of... -
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- FK778, A Synthetic Malononitrilamide
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Fitzsimmons WE, First MR
- KMID: 1726179
- Yonsei Med J.
- 2004 Dec;45(6):1132-1135.
- doi: 10.3349/ymj.2004.45.6.1132
FK778 is a synthetic malononitrilamide (MNA) that has been demonstrated to have both both immunosuppressive and anti-proliferative activities. The MNAs inhibit both T-cell and B-cell function by blocking de novo... -
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- Induction of Apoptosis in Intestinal Toxicity to a Histone Deacetylase Inhibitor in a Phase I Study with Pelvic Radiotherapy
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Kalanxhi E, Risberg K, Barua IS, Dueland S, Waagene S, Andersen S, Pettersen , Lindvall J, Redalen KR, Flatmark K, Ree AH
- KMID: 2378109
- Cancer Res Treat.
- 2017 Apr;49(2):374-386.
- doi: 10.4143/crt.2016.080
PURPOSE: When integrating molecularly targeted compounds in radiotherapy, synergistic effects of the systemic agent and radiation may extend the limits of patient tolerance, increasing the demand for understanding the pathophysiological... -
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- PF-04620110, a Potent Antidiabetic Agent, Suppresses Fatty Acid-Induced NLRP3 Inflammasome Activation in Macrophages
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Jo SI, Bae JH, Kim SJ, Lee JM, Jeong JH, Moon JS
- KMID: 2460961
- Diabetes Metab J.
- 2019 Oct;43(5):683-699.
- doi: 10.4093/dmj.2019.0112
BACKGROUND: Chronic inflammation has been linked to insulin resistance and type 2 diabetes mellitus (T2DM). High-fat diet (HFD)-derived fatty acid is associated with the activation of chronic inflammation in T2DM.... -
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- Preclinical studies for pharmacokinetics and biodistribution of Ad-stTRAIL, an adenovirus delivering secretable trimeric TRAIL for gene therapy
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Kim CY, Park SH, Jeong M, Kwon OS, Doh H, Kang SH, Robbins PD, Kim BM, Seol DW, Kim BG
- KMID: 1123370
- Exp Mol Med.
- 2011 Oct;43(10):580-586.
- doi: 10.3858/emm.2011.43.10.065
Malignant glioma is the most frequent type in brain tumors. The prognosis of this tumor has not been significantly improved for the past decades and the average survival of patients... -
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