- A possible evolutionary role of formaldehyde
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Kalapos MP
- KMID: 755020
- Exp Mol Med.
- 1999 Mar;31(1):1-4.
Formaldehyde is a compound which is believed to have had a role in evolutionary processes. On the other hand, the (methyl)glyoxalase pathway is a route being present in all biological organisms whereas... -
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- Alpha-Ketoglutarate: Physiological Functions and Applications
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Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D
- KMID: 2170534
- Biomol Ther.
- 2016 Jan;24(1):1-8.
- doi: 10.4062/biomolther.2015.078
Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source... -
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- A Case of Suspected Fumarase Deficiency Presenting with Persistent Mild Metabolic Acidosis in Newborn Infant
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Choi DY, Kim JS, Shin YJ, Park HJ, Lee IK
- KMID: 2329326
- J Korean Child Neurol Soc.
- 2005 Nov;13(2):257-261.
Fumaric aciduria(fumarase deficiency) is a rare inborn error of metabolism resulted from a deficiency of fumarase, one of the constituent enzymes of the Krebs tricarboxylic acid cycle. Enzyme deficiency causes... -
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- Fumarase Deficiency with Spastic Quadriplegia: A case report
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Jung KH, Park JH, Ko YJ, Lee SE
- KMID: 2323513
- J Korean Acad Rehabil Med.
- 2000 Aug;24(4):793-798.
Fumarase catalyzes the conversion of fumarate to malate in the Krebs cycle. Fumarase deficiency is a rare inborn error of metabolism and is inherited in an autosomal recessive manner. It... -
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- Pediatric Obesity and Non-alcoholic Fatty Liver Disease: Is It Real Problematic?
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Kim SG
- KMID: 1128351
- Korean J Gastroenterol.
- 2011 Mar;57(3):141-143.
- doi: 10.4166/kjg.2011.57.3.141
No abstract available. -
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- A Study of Cytotoxical Mechanism of Mercurial Compounds in RAW264.7 Cell Line
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Kirn KH, Soh BY, Koh DH
- KMID: 2027963
- Korean J Occup Environ Med.
- 1996 Dec;8(3):560-569.
The effects of glucose on the productions of ATP and nitrite which are inhibited by mercury compounds, were examined in a cell culture system of RAW 264.7 cells. The cells... -
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- Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
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Jeoung NH, Harris RA
- KMID: 2029884
- Korean Diabetes J.
- 2010 Oct;34(5):274-283.
- doi: 10.4093/kdj.2010.34.5.274
In the well-fed state a relatively high activity of the pyruvate dehydrogenase complex (PDC) reduces blood glucose levels by directing the carbon of pyruvate into the citric acid cycle. In... -
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- Profiling of remote skeletal muscle gene changes resulting from stimulation of atopic dermatitis disease in NC/Nga mouse model
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Lee D, Seo Y, Kim YW, Kim S, Choi J, Moon SH, Bae H, Kim HS, Kim H, Kim JH, Kim TY, Kim E, Yim S, Lim I, Bang H, Kim JH, Ko JH
- KMID: 2455813
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):367-379.
- doi: 10.4196/kjpp.2019.23.5.367
Although atopic dermatitis (AD) is known to be a representative skin disorder, it also affects the systemic immune response. In a recent study, myoblasts were shown to be involved in... -
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- Measurements of Malonate Concentration in Rabbit with Experimental SAH
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Kim JJ, Ha YS, Paik SR, Chang CS, Kim YS
- KMID: 1955077
- J Korean Neurosurg Soc.
- 1995 Oct;24(10):1121-1129.
Malonate is regarded as a reversible competitive inhibitor of succinate dehydrogenase and malate transport in the Krebs cycle and showed neurotoxicity by persistent NMDA receptor activation due to inhibition of... -
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- Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
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Park S, Jeon JH, Min BK, Ha CM, Thoudam T, Park BY, Lee IK
- KMID: 2418715
- Diabetes Metab J.
- 2018 Aug;42(4):270-281.
- doi: 10.4093/dmj.2018.0101
Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial... -
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- Biochemical Characteristics of The Na-alpha-Ketoglutarate Cotransport System in Proximal Convoluted and Straight Tubules of the Rabbit Kidney
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Ahn DW, Kim KR, Park HS, Park YS
- KMID: 2254125
- Korean J Nephrol.
- 2007 Jan;26(1):5-13.
PURPOSE: alpha-Ketoglutarate (alphaKG), a Krebs cycle intermediate, is extensively used in the kidney as a fuel substrate and as a counter anion for organic acid secretion. It is known to... -
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- Mitochondrial Dysfunction and Apoptosis Related Gene Expression in A beta(25-35)-Treated Human Neuroblastoma Cell Line, SK-N-SH
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Choi YS, Kim SH
- KMID: 2338986
- J Korean Geriatr Soc.
- 2009 Sep;13(3):142-151.
BACKGROUND: Mitochondrial dysfunction plays an important role in Abeta-induced neuronal toxicity in Alzheimer's disease (AD). We measured the membrane potentials of mitochondria (delta psim) and assessed the genetic expressions of... -
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- A Study on the Isozymic Alterations of Lactic Dehydrogenase in the Tissues ofRats Following Sulfur Dioxide Exposure
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Kwon SP
- KMID: 687611
- Yonsei Med J.
- 1969 Jun;10(1):37-47.
- doi: 10.3349/ymj.1969.10.1.37
Lactic dehydrogenase (LDH) isozyme pattens were examined in rats after exposing the animal to 250 ppm of sulfur dioxide gas. The isozymes of the respective tissues were separated on cellulose-acetate... -
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