- Basal Forebrain Cholinergic-induced Activation of Cholecystokinin Inhibitory Neurons in the Basolateral Amygdala
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Lee S, Kim JH
- KMID: 2451068
- Exp Neurobiol.
- 2019 Jun;28(3):320-328.
- doi: 10.5607/en.2019.28.3.320
The basolateral amygdala (BLA) receives dense projections from cholinergic neurons of the basal forebrain. Acetylcholine can contributes to amygdala-dependent behaviors: formation and extinction of fear memory and appetitive instrumental learning.... -
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- beta-Amyloid Neurotoxicity on Basal Forebrain Cholinergic Neuron Cultures
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Kim DH, Lee JH, Hong HN, Ko JY
- KMID: 1529459
- Korean J Anat.
- 1997 Jun;30(3):225-234.
beta-amyloid[Abeta] peptide consisting of 40 of 42 amino acids peptide is the principal constituent of senile plaques in Alzheimer`s disease. Recently, it has been demonstrated that this peptide and its... -
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- Distribution of the Mouse Striatal Cholinergic Neurons in Their Early Postnatal Period
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Hann HJ, Lee HL
- KMID: 2092652
- Korean J Anat.
- 1998 Aug;31(4):503-511.
The category of striatal complex contains caudate nucleus, putamen, nucleus accumbens septi, and olfactory tubercle. The striatal complex is composed of two compartments, dorsal and ventral striatum. In the striatum,... -
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- Distribution Pattern and Synaptic Circuitry of Cholinergic Neurons in the Rat Retina
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Kim IB, Oh SJ, Na WK, Lee MY, Chun MH
- KMID: 2092648
- Korean J Anat.
- 1998 Feb;31(1):137-150.
The role of acetylcholine as an excitatory neurotransmitter is well established, and cholinergic neurons appear to play an important role in the mammalian retinae. Though it has been reported that... -
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- Synaptic Morphology of the Mouse Striatal Cholinergic Neurons in the Early Postnatal Life
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Hann HJ, Lee HL
- KMID: 2224577
- Korean J Anat.
- 1999 Apr;32(2):161-170.
The cholinergic neurons in the striatal complex are the major interneurons that integrate the informations incoming to and outflowing from the striatum. The shape of synapses may change even after... -
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- Brain Mechanisms Generating REM Sleep
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Sohn JW
- KMID: 2317251
- Sleep Med Psychophysiol.
- 1995 Dec;2(2):133-137.
The author reviews current knowledge about what REM sleep is and where and how it is generated. REM sleep is the state in which our most vivid dreams occur. REM... -
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- Muscarine M2 Receptor-mediated Presynaptic Inhibition of GABAergic Transmission in Rat Meynert Neurons
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Jang IS, Akaike N
- KMID: 1614991
- Korean J Physiol Pharmacol.
- 2002 Apr;6(2):63-70.
Cholinergic modulation of GABAergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) by the activation of muscarine receptors was investigated in mechanically dissociated rat nucleus basalis of the Meynert neurons using the... -
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- Basal Forebrain Cholinergic Deficits Reduce Glucose Metabolism and Function of Cholinergic and GABAergic Systems in the Cingulate Cortex
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Jeong DU, Oh JH, Lee JE, Lee J, Cho ZH, Chang JW, Chang WS
- KMID: 2466366
- Yonsei Med J.
- 2016 Jan;57(1):165-172.
- doi: 10.3349/ymj.2016.57.1.165
PURPOSE: Reduced brain glucose metabolism and basal forebrain cholinergic neuron degeneration are common features of Alzheimer's disease and have been correlated with memory function. Although regions representing glucose hypometabolism in... -
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- Effects of gamma-Aminobutyric Acid on Intrinsic Cholinergic Action in Exocrine Secretion of Isolated, Perfused Rat Pancreas
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Park YD, Park HS, Cui ZY, Park HJ
- KMID: 2071592
- Korean J Physiol Pharmacol.
- 2003 Jun;7(3):169-174.
gamma-Aminobutyric acid (GABA) has been reported to enhance exocrine secretion evoked not only by secretagogues but also by intrinsic neuronal excitation in the pancreas. The pancreas contains cholinergic neurons abundantly... -
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- Choline Acetyltrans ferase Immunoreactivity in the Rat Brainstem
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Kim ES, Han DH
- KMID: 2338343
- J Korean Geriatr Soc.
- 2004 Sep;8(3):170-176.
BACKGROUND: Cholinergic neurons in the forebrain of mamals are well elucidated, meanwhile, the distribution of these neurons in the brainstem is not conformed according to investigators. To identify cholinergic neurons... -
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- Effect of Placenta-Derived Mesenchymal Stem Cells in a Dementia Rat Model via Microglial Mediation: a Comparison between Stem Cell Transplant Methods
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Cho JS, Lee J, Jeong DU, Kim HW, Chang WS, Moon J, Chang JW
- KMID: 2407864
- Yonsei Med J.
- 2018 May;59(3):406-415.
- doi: 10.3349/ymj.2018.59.3.406
PURPOSE: Loss of cholinergic neurons in the hippocampus is a hallmark of many dementias. Administration of stem cells as a therapeutic intervention for patients is under active investigation, but the... -
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- Estrogen and Alzheimer's Disease
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Lee JS, Kim CH
- KMID: 2286993
- Korean J Psychopharmacol.
- 1997 Apr;8(1):48-54.
Aging of the population in industrialized countries, as a result of increased life expectancy, is known to be associated with an increased risk of dementia, especially Alzheimer's disease. Estrogen use... -
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- Effects on 5-HT and Ach in the Rat by the I.C.V Injection of PCPA
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Pae YS
- KMID: 1965083
- Ewha Med J.
- 1993 Dec;16(4):321-330.
- doi: 10.12771/emj.1993.16.4.321
PCPA is a drug which depletes serotonin by inhibiting tryptophan hydroxylase activity. Recent evidence indicates that the ascending cholinergic projection from the basal forebrain and ascending serotonergic projections from the brain... -
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- Evidence of early involvement of apoptosis inducing factor-induced neuronal death in Alzheimer brain
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Lee JH, Cheon YH, Woo RS, Song DY, Moon C, Baik TK
- KMID: 1447450
- Anat Cell Biol.
- 2012 Mar;45(1):26-37.
- doi: 10.5115/acb.2012.45.1.26
Apoptosis inducing factor (AIF) has been proposed to act as a putative reactive oxygen species scavenger in mitochondria. When apoptotic cell death is triggered, AIF translocates to the nucleus, where... -
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- Novel Pharmacotherapies for Alzheimer's Disease
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Han SH
- KMID: 2188088
- J Korean Med Assoc.
- 2009 Nov;52(11):1059-1068.
- doi: 10.5124/jkma.2009.52.11.1059
Alzheimer disease (AD) is pathologically characterized by extracellular amyloid deposits composed of beta-amyloid (A beta) peptide, neurofibrillary tangles (NFTs) made up of hyperphosphorylated tau, and deficit of cholinergic neurons in... -
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- Neuroimmune interactions and kidney disease
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Hasegawa S, Inoue T, Inagi R
- KMID: 2457720
- Kidney Res Clin Pract.
- 2019 Sep;38(3):282-294.
- doi: 10.23876/j.krcp.19.014
The autonomic nervous system plays critical roles in maintaining homeostasis in humans, directly regulating inflammation by altering the activity of the immune system. The cholinergic anti-inflammatory pathway is a well-studied... -
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- Wogonin Attenuates Hippocampal Neuronal Loss and Cognitive Dysfunction in Trimethyltin-Intoxicated Rats
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Lee B, Sur B, Cho SG, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2164226
- Biomol Ther.
- 2016 May;24(3):328-337.
- doi: 10.4062/biomolther.2015.152
We examined whether wogonin (WO) improved hippocampal neuronal activity, behavioral alterations and cognitive impairment, in rats induced by administration of trimethyltin (TMT), an organotin compound that is neurotoxic to these... -
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- Vivid Dreaming after Acetyl-L-Carnitine Administration: A Report of Two Cases
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Kim H, Yoon DY, Park DY, Han HJ
- KMID: 2340304
- J Korean Geriatr Soc.
- 2014 Sep;18(3):162-164.
- doi: 10.4235/jkgs.2014.18.3.162
Acetyl-L-carnitine (ALC), an acetylated form of L-carnitine, is able to influence the activity of cholinergic neurons, cell membrane stabilization and enhancing mitochondrial function. A 52-year-old woman was referred to neurology... -
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- Neurobiology of Age-Associated Memory Impairment
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Kim SH, Shin KH
- KMID: 2064040
- J Korean Geriatr Psychiatry.
- 2001 Jun;5(1):17-24.
The diagnostic concept of age-associated memory impairment (AAMI) suggests that clinically recognized memory dysfunction could be a feature of normal aging. Although the memory impairment associated with aging is well... -
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- Phellodendron amurense and Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in Rats
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Lee B, Sur B, Shim I, Lee H, Hahm DH
- KMID: 2071752
- Korean J Physiol Pharmacol.
- 2012 Apr;16(2):79-89.
- doi: 10.4196/kjpp.2012.16.2.79
We examine whether Phellodendron amurense (PA) and its major alkaloid compound, berberine (BER), improved memory defects caused by administering scopolamine in rats. Effects of PA and BER on the acetylcholinergic... -
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