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Use of serology and polymerase chain reaction to detect atypical respiratory pathogens during acute exacerbation of chronic obstructive pulmonary disease

Jung CY, Choe YH, Lee SY, Kim WJ, Lee JD, Ra SW, Choi EG, Lee JS, Park MJ, Na JO

BACKGROUND/AIMS: To use serological and multiplex polymerase chain reaction (PCR) assays to examine sputum samples from patients experiencing acute exacerbation of chronic obstructive pulmonary disease (AECOPD) for the presence of...
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Distribution and Characterization of Airborne Respiratory Pathogens in Public Facilities

Hwang SJ, Yun HC, Ku PT, Sim JH, Cha YW, Lee MO

Respiratory infections, which are caused by airborne pathogens, are the most common disease of all ages worldwide. This study was conducted to characterize the airborne respiratory pathogens in the public...
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Robust immunoreactivity of teenager sera against peptide 19 from Porphyromonas gingivalis HSP60

Kwon EY, Cha GS, Joo JY, Lee JY, Choi J

PURPOSE: Epitope spreading is a phenomenon in which distinct subdominant epitopes become major targets of the immune response. Heat shock protein (HSP) 60 from Porphyromonas gingivalis (PgHSP60) and peptide 19...
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Evaluation of EuDxâ„¢-PN MLC Detection Kit for Detection of Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila in Respiratory Specimens

Lee MK, Sung H, Cho AR, Chi HY

BACKGROUND: Infection by the intracellular bacteria Mycoplasma pneumoniae, Chamydophila pneumoniae, and Legionella pneumophila are common causes of community-acquired pneumonia (CAP). This study describes the evaluation of a new multiplex real-time...
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Clinical presentations of Chlamydia pneumoniae in children hospitalized for acute respiratory infections: a comparison to Mycoplasma pneumonia

Sung JJ, Kim EJ, Sun YH, Jeon IS, Tchah H, Ryoo E, Son DW, Cho HK, Cho HJ, Kim NY

PURPOSE: Chlamydia pneumoniae is a common intracellular bacterial pathogen and plays an important role in acute respiratory infections. The purpose of this study was to investigate clinical presentations of C....
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Role of Atypical Pathogens and the Antibiotic Prescription Pattern in Acute Bronchitis: A Multicenter Study in Korea

Park S, Oh KC, Kim KS, Song KT, Yoo KH, Shim YS, Lee YJ, Lee MG, Yun JU, Kim HS, Kim YH, Lee WJ, Kim DI, Cha HG, Lee JM, Seo JS, Jung KS

The role of atypical bacteria and the effect of antibiotic treatments in acute bronchitis are still not clear. This study was conducted at 22 hospitals (17 primary care clinics and...
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A Case of Childhood Paroxysmal Cold Hemoglobinuria Related with Suspicious Chlamydia Infection

Yoon JH, Cho JS, Park HJ, Shim H, Kong SY, Yoon JY, Park BK

Paroxysmal cold hemoglobinuria (PCH) is a rare diagnosis of acquired hemolytic anemia in children, which is caused by a specific cold antibody named Donath-Landsteiner hemolysin. Although various bacteria or viruses...
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Efficiency of Chlamydia Pneumoniae Culture in the Upper Airway Epithelial Cell Lines: AMC-HN-4, AMC-HN-7, and AMC-HN-8

Choi DH, Lee SJ, Won JY

BACKGROUND AND OBJECTIVES: Chlamydia pneumoniae (C. pneumoniae) is a well-known pathogen of upper and lower respiratory tract infection. For a more efficient and practical cell culture system, we studied the...
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Association between Intracellular Infectious Agents and Schizophrenia

Park MH, Kwon YJ, Jeong HY, Lee HY, Hwangbo Y, Yoon HJ, Shim SH

  • KMID: 2171219
  • Clin Psychopharmacol Neurosci.
  • 2012 Aug;10(2):117-123.
OBJECTIVE: A number of studies have reported association between Toxoplasma gondii (T. gondii) and Chlamydia infection and the risk of schizophrenia. The aim of the present study was to compare...
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Comparison of Sputum and Nasopharyngeal Aspirates for Molecular Detection of Community-Acquired Pneumonia Pathogens

Kim S, Lee SS, Jung H, Park HK, Cho CR, Um TH

  • KMID: 1820221
  • J Lab Med Qual Assur.
  • 2012 Jun;34(1):37-41.
BACKGROUND: Community-acquired pneumonia (CAP) is a leading cause of infectious diseases and mortality. CAP is primarily treated by administration of adequate antibiotics against the causative pathogens. Because detection of some...
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Comparison of Sputum and Nasopharyngeal Swab Specimens for Molecular Diagnosis of Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila

Cho MC, Kim H, An D, Lee M, Noh SA, Kim MN, Chong YP, Woo JH

BACKGROUND: Differentiation of atypical pathogens is important for community-acquired pneumonia (CAP). In this study, we compared sputum and nasopharyngeal swabs (NPS) for use in detection of Mycoplasma pneumoniae (MP), Chlamydophila...
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Mycoplasma pneumoniae Pneumonia Unresponsive to Macrolide Treatment

Ji M, Sung H, Shim TS, Jang W, Kim MN

  • KMID: 2312211
  • Lab Med Online.
  • 2012 Oct;2(4):226-231.
We present a case of community-acquired pneumonia (CAP) that developed in a previously healthy young woman. She was diagnosed with Mycoplasma pneumoniae pneumonia, but did not respond to macrolide treatment....
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Comparison of Collagen-coated Polyethylene Terephthalate Disc Plate and Shell Vial Culture Method for the Isolation of Chlamydophila pneumoniae

Kim MH, Lee WK

BACKGROUND: Chlamydophila pneumoniae is one of the major respiratory infectious pathogens and can be accurately diagnosed by cell culturing. The author performed this study to compare the usefulness of the...
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Clinical Evaluation of the Multiplex PCR Assay for the Detection of Bacterial Pathogens in Respiratory Specimens from Patients with Pneumonia

Jung CL, Lee MA, Chung WS

BACKGROUND: Community-acquired pneumonia (CAP) is a major infectious disease with significant morbidity and mortality worldwide. Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, and Bordetella pertussis are common...
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Infection Rate of Chlamydia pneumoniae in Patients with Chronic Cough

Chun SY, Park KO, Park YB, Choi JH, Lee JY, Mo EK, Park SH, Kim CH, Lee CY, Hwang YI, Jang SH, Shin TR, Park SM, Kim DG, Lee MG, Hyun IG, Jung KS

  • KMID: 2319452
  • Tuberc Respir Dis.
  • 2010 Dec;69(6):426-433.
BACKGROUND: Persistent cough has recently been found to be associated with Chlamydia pneumoniae infection. We aimed to investigate the infection rate of C. pneumonia in adult patients with chronic cough. METHODS:...
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The Bacterial Etiology of Community-Acquired Pneumonia in Korea: A Nationwide Prospective Multicenter Study

Chong YP, Jung KS, Lee KH, Kim MN, Moon SM, Park S, Hur J, Kim DM, Jeon MH, Woo JH

BACKGROUND: Successful therapy for community-acquired pneumonia (CAP) requires appropriate empirical antimicrobial therapy based on the local microbe and resistance patterns. However, the available data on the bacterial etiology and antimicrobial...
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Chlamydophila pneumoniae enhances secretion of VEGF, TGF-beta and TIMP-1 from human bronchial epithelial cells under Th2 dominant microenvironment

Park CS, Kim TB, Moon KA, Bae YJ, Lee HR, Jang MK, Moon HB, Cho YS

PURPOSE: Chlamydophila pneumoniae infection in the airways is thought to be associated with the pathogenesis of asthma, especially in non-atopic severe asthma with irreversible airway obstruction that may be related...
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The Clinical Significance of Nasopharyngeal Carriages in Immunocompromised Children as Assessed

Kim KH, Shin JH, Kim SY

BACKGROUND: The aim of this study was to determine the prevalence of asymptomatic nasopharyngeal carriages in immunocompromized children by using a multiplex reverse transcriptase-polymerase chain reaction (mRT-PCR) assay kit. METHODS:...
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Detection of nasopharyngeal carriages in children by multiplex reverse transcriptase-polymerase chain reaction

Shin JH, Han HY, Kim SY

PURPOSE: The aim of this study was to determine the prevalence of asymptomatic nasopharyngeal carriages in children using a multiplex reverse transcriptase-polymerase chain reaction (mRT-PCR) assay kit. METHODS: We obtained...
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The Effect of Chlamydia pneumoniae on the Expression of Peroxisome Proliferator-Activated Receptor-gamma in Vascular Smooth Muscle Cells

Kim YH, Choi SY, Suh JH, Kim TK, Seung KB, Wang YP, Chang K

PURPOSE: This study was designed to investigate the change of peroxisome proliferator-activated receptor gamma (PPARgamma) after the infection of the human coronary artery smooth muscle cells (HCSMCs) with Chlamydia pneumoniae...
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