Korean J Clin Microbiol.  2005 Apr;8(1):41-46.

Association of Chlamydophila pneumoniae, Cytomegalovirus, Helicobacter pylori and HIV Infections with Myocardial Infarction

• Heo WB
• Kim YK
• Eun SJ
• Ryu JK
• Lee WK

Abstract

BACKGROUND
There is some evidence linking the infections with common organisms such as Chlamydophila pneumoniae, cytomegalovirus (CMV), Helicobacter pylori and HIV to myocardial infarction (MI). We had performed a serologic study to assess whether C.pneumoniae, CMV, H. pylori and HIV infections are associated with MI.
METHODS
Serum samples were obtained from 54 cases of acute MI, 33 cases of old MI, and 60 normal controls. C-reactive protein (CRP) as an inflammation marker was measured and antibodies to C.pneumoniae, CMV, H.pylori and HIV were assayed by ELISA. Odds ratios (OR) were calculated against control group.
RESULTS
CRP was significantly higher in the acute MI and old MI group. ORs of C.pneumoniae infection increased considerably in the acute MI (IgM 1.57, IgG 4.80) and old MI group (IgM 2.42, IgG 5.18). ORs of CMV infection were 3.30 in the acute MI and 5.12 in old MI group. ORs of H. pylori infection showed below 1 in the acute MI and old MI. Anti-HIV antibody showed all negative result in three groups, so OR could not be calculated.
CONCLUSION
C.pneumoniae and CMV infections appear to be risk factors for MI.

Keyword

Myocardial infarction; Chlamydophila pneumoniae; Cytomegalovirus; Helicobacter pylori; HIV; Coronary artery disease; Risk factors

MeSH Terms

Antibodies
C-Reactive Protein
Chlamydial Pneumonia*
Chlamydophila pneumoniae*
Chlamydophila*
Coronary Artery Disease
Cytomegalovirus*
Enzyme-Linked Immunosorbent Assay
Helicobacter pylori*
Helicobacter*
HIV Infections*
HIV*
Immunoglobulin G
Inflammation
Myocardial Infarction*
Odds Ratio
Risk Factors
Antibodies
C-Reactive Protein
Immunoglobulin G