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MRI Assessment of Cerebral Small Vessel Disease in Patients with Spontaneous Intracerebral Hemorrhage

Park YS, Chung MS, Choi BS

PURPOSE: Cerebral small vessel disease (SVD) is known to be associated with ischemic stroke, intracerebral hemorrhage (ICH), and cognitive impairment. In this retrospective observational study, we explored SVD markers on...
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Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies

Das AS, Regenhardt RW, Vernooij M, Blacker D, Charidimou A, Viswanathan A

Cerebral small vessel disease (CSVD) is a common group of neurological conditions that confer a significant burden of morbidity and mortality worldwide. In most cases, CSVD is only recognized in...
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A Comparison Study of Cilostazol and Aspirin on Changes in Volume of Cerebral Small Vessel Disease White Matter Changes: Protocol of a Multicenter, Randomized Controlled Trial

Han HJ, Kim BC, Youn YC, Jeong JH, Kim JH, Lee JH, Park KH, Park KW, Kim EJ, Oh MS, Shim YS, Park HY, Yoon B, Yoon SJ, Cho SJ, Park KC, Na DL, Park SA, Lee JM, Choi SH

BACKGROUND AND PURPOSE: Cerebral small vessel disease (CSVD) is the most common cause of vascular dementia and a major contributor to mixed dementia. CSVD is characterized by progressive cerebral white...
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Prospective Memory Loss and Related White Matter Changes in Patients with Amnestic Mild Cognitive Impairment

Yoon B, Ryu SY, Yoon SJ

BACKGROUND AND PURPOSE: Prospective memory (PM) has a known relationship with frontal function, and PM decline has been observed in amnestic mild cognitive impairment (aMCI). Cerebral small vessel disease, as...
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Cerebral Small Vessel Disease: A Review Focusing on Pathophysiology, Biomarkers, and Machine Learning Strategies

Cuadrado-Godia E, Dwivedi P, Sharma S, Ois Santiago A, Roquer Gonzalez J, Balcells M, Laird J, Turk M, Suri HS, Nicolaides A, Saba L, Khanna NN, Suri JS

Cerebral small vessel disease (cSVD) has a crucial role in lacunar stroke and brain hemorrhages and is a leading cause of cognitive decline and functional loss in elderly patients. Based...
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Pulsatility of middle cerebral arteries is better correlated with white matter hyperintensities than aortic stiffening

Lee SH, Kim Y, Lee Y, Lee JH

BACKGROUND: Pulsatility of cerebral arteries and aortic stiffness have been associated with white matter hyperintensities (WMH). We explored which is better correlated with the severity of WMH in a population...
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Prevalence and Risk Factors of Cerebral Small Vessel Disease in a Chinese Population-Based Sample

Han F, Zhai FF, Wang Q, Zhou LX, Ni J, Yao M, Li ML, Zhang SY, Cui LY, Jin ZY, Zhu YC

BACKGROUND AND PURPOSE: Epidemiological data of cerebral small vessel disease (CSVD) in the general population of China are lacking. We report on the prevalence of lacunes, white matter hyperintensity (WMH),...
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Serum Neurofilament Light Chain Levels Are Related to Small Vessel Disease Burden

Duering M, Konieczny , Tiedt S, Baykara E, Tuladhar A, van Leijsen E, Lyrer P, Engelter S, Gesierich , Achmüller M, Barro C, Adam R, Ewers M, Dichgans M, Kuhle J, de Leeuw F, Peters N

BACKGROUND AND PURPOSE: Neurofilament light chain (NfL) is a blood marker for neuroaxonal damage. We assessed the association between serum NfL and cerebral small vessel disease (SVD), which is highly...
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Updates on Prevention of Hemorrhagic and Lacunar Strokes

Tsai HH, Kim JS, Jouvent E, Gurol ME

Intracerebral hemorrhage (ICH) and lacunar infarction (LI) are the major acute clinical manifestations of cerebral small vessel diseases (cSVDs). Hypertensive small vessel disease, cerebral amyloid angiopathy, and hereditary causes, such...
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Distribution Analysis of Cerebral Microbleeds in Alzheimer's Disease and Cerebral Infarction with Susceptibility Weighted MR Imaging

Park MY, Park HJ, Shin DS

BACKGROUND: Cerebral microbleeds (CMBs) reflect cerebral small vessel disease and has a pathological role in Alzheimer's disease (AD) and stroke according to their distribution. We investigated to determine whether association...
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Association between Aortic Atheroma and Cerebral Small Vessel Disease in Patients with Ischemic Stroke

Song TJ, Kim YD, Yoo J, Kim J, Chang HJ, Hong GR, Shim CY, Song D, Heo JH, Nam HS

BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVDs) are related with large artery atherosclerosis. However, the association between aortic atheroma (AA) and cerebral small vessel disease has rarely been reported....
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Phenotypic Features of Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Subjects with R544C Mutation

Lee JS, Ko K, Oh JH, Park JH, Lee HK

BACKGROUND AND PURPOSE: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most-common single gene disorder of cerebral small vessel disease. There is no definite evidence of genotype-phenotype...
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Is the Severity of Dilated Virchow-Robin Spaces Associated with Cognitive Dysfunction?

Jeong EH, Lee YJ, Kim SJ, Lee JH

BACKGROUND AND PURPOSE: Dilated Virchow-Robin spaces (dVRS) are not uncommon findings in the normal brain, particularly in the old people, and have been largely regarded as benign lesions. However, there...
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Association between Helicobacter pylori Infection and Cerebral Small Vessel Disease

Jang SH, Lee H, Kim JS, Park HJ, Jeong SM, Lee SH, Kim HH, Park JH, Shin DW, Yun JM, Cho B, Kwon HM

BACKGROUND: Small vessel disease is an important cause of cerebrovascular diseases and cognitive impairment in the elderly. There have been conflicting results regarding the relationship between Helicobacter pylori infection and...
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Prevention and Management of Cerebral Small Vessel Disease

Mok V, Kim JS

Lacunar infarcts/lacunes, white matter hyperintensities (WMH), and cerebral microbleeds (CMBs) are considered various manifestations of cerebral small vessel disease (SVD). Since the exact mechanisms of these manifestations differ, their associated...
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Prognostic Impact of Cerebral Small Vessel Disease on Stroke Outcome

Kim BJ, Lee SH

Cerebral small vessel disease (SVD), which includes white matter hyperintensities (WMHs), silent brain infarction (SBI), and cerebral microbleeds (CMBs), develops in a conjunction of cumulated injuries to cerebral microvascular beds,...
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Evolving Concept of Small Vessel Disease through Advanced Brain Imaging

Norrving B

Imaging plays a crucial role in studying and understanding cerebral small vessel disease. Several important findings have emerged from recent applications of advanced brain imaging methods. In patients with acute...
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Cerebral Small Vessel Disease and Chronic Kidney Disease

Toyoda K

Chronic kidney disease, defined by a decreased glomerular filtration rate or albuminuria, is recognized as a major global health burden, mainly because it is an established risk factor for cardiovascular...
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Genetics of Cerebral Small Vessel Disease

Choi JC

Cerebral small vessel disease (SVD) is an important cause of stroke and cognitive impairment among the elderly and is a more frequent cause of stroke in Asia than in the...
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Lacunar Infarction and Small Vessel Disease: Pathology and Pathophysiology

Caplan LR

Two major vascular pathologies underlie brain damage in patients with disease of small size penetrating brain arteries and arterioles; 1) thickening of the arterial media and 2) obstruction of the...
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