- Aspirin-induced Bcl-2 translocation and its phosphorylation in the nucleus trigger apoptosis in breast cancer cells
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Choi BH, Chakraborty G, Baek K, Yoon HS
- KMID: 2154266
- Exp Mol Med.
- 2013 Oct;45(10):e47.
Here, we report that B-cell lymphoma 2 (Bcl-2) is a novel target molecule of aspirin in breast cancer cells. Aspirin influenced the formation of a complex by Bcl-2 and FKBP38... -
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- Current Concepts of Stem Cell Therapy
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Hwang JH
- KMID: 2272495
- Korean J Obstet Gynecol.
- 2005 Jan;48(1):14-20.
Stem cells are defined by their capacity for self-renewal and multilineage differentiation, making them uniquely situated to treat a broad spectrum of human diseases. The transplantation of tissue-specific stem cells,... -
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- Protective mechanism of glucose against alloxan-induced beta-cell damage: pivotal role of ATP
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Rho HW, Lee JN, Kim HR, Park BH, Park JW
- KMID: 927128
- Exp Mol Med.
- 2000 Mar;32(1):12-17.
Glucose prevents the development of diabetes induced by alloxan. In the present study, the protective mechanism of glucose against alloxan-induced beta-cell damage was investigated using HIT-T 15 cell, a Syrian... -
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- The molecular mechanism for nuclear transport and its application
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Kim YH, Han ME, Oh SO
- KMID: 2451231
- Anat Cell Biol.
- 2017 Jun;50(2):77-85.
- doi: 10.5115/acb.2017.50.2.77
Transportation between the cytoplasm and the nucleoplasm is critical for many physiological and pathophysiological processes including gene expression, signal transduction, and oncogenesis. So, the molecular mechanism for the transportation needs... -
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- Ultrastructural and Autoradiographic Studies of the Effect of Aflatoxin G1 on Hepatic Cells
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Kim CS, Lee YB
- KMID: 687681
- Yonsei Med J.
- 1974 Jun;15(1):17-26.
- doi: 10.3349/ymj.1974.15.1.17
To investigate toxicity of aflatoxin Gl and its mechanism, light microscopic, histochemical, electron microscopic and autoradiographic studies were done on the rat liver at various time intervals after the administration... -
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- The Correlations of E-Cadherin Catenin Complex(alpha, beta, gamma, p120cat) Expressions and Clinicopathological Findings in Tongue Cancer
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Shim WY, Wang SG, Lee BJ, Rho HJ, Goh EK, Chon KM, Park DY
- KMID: 2276251
- Korean J Otolaryngol-Head Neck Surg.
- 2004 Oct;47(10):1004-1012.
BACKGROUND AND OBJECTIVES: E-cadherin and catenins (alpha, beta, gamma, p120cat) are important epithelial adhesion molecules in normal epithelial cells. Loss of E-cadherin-catenin adhesion is an important step in the progression... -
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- Significance of the Nuclear Grade as a Prognostic Factor for Patients with Localized Renal Cell Carcinoma
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Ha JY, Chang HS, Kim CI
- KMID: 2061249
- Korean J Urol.
- 2007 May;48(5):471-476.
- doi: 10.4111/kju.2007.48.5.471
PURPOSE: As the number of patients with localized renal cell carcinoma has increased, there are conflicting reports on the nuclear grade as a prognostic factor. The aim of this study... -
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- Distinct Patterns of Cleavage and Translocation of Cell Cycle Control Proteins in CD95-induced and p53-induced apoptosis
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Park WS, Jung KC, Chung DH, Nam WD, Choi WJ, Bae Y
- KMID: 648894
- J Korean Med Sci.
- 2003 Aug;18(4):467-472.
- doi: 10.3346/jkms.2003.18.4.467
Apoptotic cell death induced by p53 occurs at a late G1 cell cycle checkpoint termed the restriction(R)point, and it has been proposed that p53-induced apoptosis causes upregulation of CD95. However,... -
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- What is the Meaning of Anaphase-Promoting Complex 7 in Malignant Neoplasms?
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Chang WY
- KMID: 2391452
- Ann Coloproctol.
- 2017 Aug;33(4):123-124.
- doi: 10.3393/ac.2017.33.4.123
No abstract available. -
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- Characterization of mesenchymal cells beneath cornification of the fetal epithelium and epidermis at the face: an immunohistochemical study using human fetal specimens
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Kim JH, Jin ZW, Murakami G, Cho BH
- KMID: 2308931
- Anat Cell Biol.
- 2016 Mar;49(1):50-60.
- doi: 10.5115/acb.2016.49.1.50
Fetal development of the face involves a specific type of cornification in which keratinocytes provide a mass or plug to fill a cavity. The epithelial-mesenchymal interaction was likely to be... -
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- Biliary intraepithelial neoplasia: a case with benign biliary stricture
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Jung W, Kim BH
- KMID: 1792613
- Korean J Hepatol.
- 2011 Dec;17(4):328-330.
- doi: 10.3350/kjhep.2011.17.4.328
No abstract available. -
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- Paraquat Induces Apoptosis through a Mitochondria-Dependent Pathway in RAW264.7 Cells
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Jang YJ, Won JH, Back MJ, Fu Z, Jang JM, Ha HC, Hong S, Chang M, Kim DK
- KMID: 2380288
- Biomol Ther.
- 2015 Sep;23(5):407-413.
- doi: 10.4062/biomolther.2015.075
Paraquat dichloride (N,N-dimethyl-4-4'-bipiridinium, PQ) is an extremely toxic chemical that is widely used in herbicides. PQ generates reactive oxygen species (ROS) and causes multiple organ failure. In particular, PQ has... -
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- The Degrees of Hepatocyte Cytoplasmic Expression of Hepatitis B Core Antigen correlate with Histologic Activity of Liver Disease in the Young Patients with Chronic Hepatitis B Infection
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Kim TH, Cho EY, Oh HJ, Choi CS, Kim JW, Moon HB, Kim HC
- KMID: 1781835
- J Korean Med Sci.
- 2006 Apr;21(2):279-283.
- doi: 10.3346/jkms.2006.21.2.279
Subcellular localizaton of HBcAg have been found to be related to the activity of liver disease and HBV replication. The aim of this study was to determine whether the degree... -
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- Interleukin-1beta promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways
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Lim JH, Um HJ, Park JW, Lee IK, Kwon TK
- KMID: 1009397
- Exp Mol Med.
- 2009 Oct;41(10):757-764.
- doi: 10.3858/emm.2009.41.10.082
Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this... -
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- The Production of Micronuclei from Chromosome Aberrations by Chemical Carcinogens in Mice
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Hahn S, Kim DS
- KMID: 687777
- Yonsei Med J.
- 1979 Dec;20(2):105-112.
- doi: 10.3349/ymj.1979.20.2.105
The effect of four alkylating agents (MMS, EMs, DMN, DEM), under various con centrations on mouse bone marrow erythrocytes, were studied by means of the micronucleus test. The results obtained... -
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- The hydrophobic amino acids involved in the interdomain association of phospholipase D1 regulate the shuttling of phospholipase D1 from vesicular organelles into the nucleus
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Jang YH, Min DS
- KMID: 1506220
- Exp Mol Med.
- 2012 Oct;44(10):571-577.
Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid. PLD is localized in most cellular organelles, where it is likely to play different... -
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- A Case of Salmonella Osteomyelitis in a Patient with Systemic Lupus Erythematosus
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Song JS, Park W, Um HS, Bae SK, Choi SW, Kim MK, Lee JW, Bae SH
- KMID: 1544939
- J Korean Rheum Assoc.
- 1999 Mar;6(1):91-96.
Systemic lupus ertthematosus(SLE) is a prototypic autoimmune disease characterized by the production of antibodies to components of the cell nucleus in association with a diverse array of clinical manifestations. Infection... -
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- Expression of p73 in Non-small Cell Lung Carcinomas
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Jung JH, Park G, Jung CK, Choi HJ, Yoo J, Kang SJ, Lee KY
- KMID: 2073780
- Korean J Pathol.
- 2007 Apr;41(2):109-115.
BACKGROUND: The p73 is a recently identified homologue of the tumor suppressor gene, p53, and it has been found to induce apoptosis and inhibit cell proliferation. However, its role in... -
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- Langerhans cell protein 1 (LCP1) binds to PNUTS in the nucleus: implications for this complex in transcriptional regulation
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Lee SJ, Lee JK, Maeng YS, Kim YM, Kwon YG
- KMID: 1123466
- Exp Mol Med.
- 2009 Mar;41(3):189-200.
- doi: 10.3858/emm.2009.41.3.022
Protein phosphatase-1 (PP1) nuclear targeting subunit (PNUTS), also called PP1R10, p99, or CAT 53 was originally isolated as a mammalian nuclear PP1-binding protein. In this study, we performed yeast two-hybrid... -
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- Synergistic Effect of Interleukin-6 and Hyaluronic Acid on Cell Migration and ERK Activation in Human Keratinocytes
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Choi JH, Jun JH, Kim JH, Sung HJ, Lee JH
- KMID: 2151415
- J Korean Med Sci.
- 2014 Nov;29(Suppl 3):S210-S216.
- doi: 10.3346/jkms.2014.29.S3.S210
Wound healing is initiated and progressed by complex integrated process of cellular, physiologic, and biochemical events, such as inflammation, cell migration and proliferation. Interleukin 6 (IL-6) is a multifunctional cytokine,... -
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