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Degranulation of human eosinophils induced by Paragonimus westermani-secreted protease

Shin MH, Chung YB, Kita H

Eosinophil degranulation is considered to be a key effector function for the killing of helminthic worms and tissue inflammation at worm-infected lesion sites. However, relatively little data are available with...
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Atrial natriuretic peptide induces rat peritoneal mast cell activation by cGMP-independent and calcium uptake-dependent mechanism

Chai OH, Lee YH, Han EH, Kim HT, Lee MS, Song CH

  • KMID: 755096
  • Exp Mol Med.
  • 2000 Dec;32(4):179-186.
Atrial natriuretic peptide (ANP), a 28 amino acid basic polypeptide, is known to induce histamine release from human and rat mast cells in vitro and cause a wheel...
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A 27 kDa Cysteine Protease Secreted by Newly Excysted Paragonimus westermani Metacercariae Induces Superoxide Anion Production and Degranulation of Human Eosinophils

Chung YB, Kita H, Shin MH

Eosinophil degranulation plays a crucial role in tissue inflammatory reactions associated with helminth parasitic nfections and allergic diseases. Paragonimus westermani, a lung fluke causing human paragonimiasis, secretes a large amount...
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Activation of MAPK Is Required for ROS Generation and Exocytosis in HMC-1 Cells Induced by Trichomonas vaginalis-Derived Secretory Products

Narantsogt G, Min A, Nam YH, Lee YA, Kim KA, Agvaandaram G, Dorjsuren , El-Benna J, Shin MH

Trichomonas vaginalis is a flagellated protozoan parasite that causes vaginitis and cervicitis in women and asymptomatic urethritis and prostatitis in men. Mast cells have been reported to be predominant in...
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Inhibition of Mast Cell Function and Proliferation by mTOR Activator MHY1485

Rakhmanova V, Jin M, Shin J

Mast cells integrate innate and adaptive immunity and are implicated in pathophysiological conditions, including allergy, asthma, and anaphylaxis. Cross-linking of the high-affinity IgE receptor (FcεRI) initiates diverse signal transduction pathways...
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Dermal mast cell responses in Paragonimus westermani-infected mice

Shin MH

This study was carried out to determine whether dermal mast cell responses to Paragonimus westermani in an abnormal host, the mouse, were dependent on the site of metacercarial inoculation....
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Mechanisms and therapeutic targets of ischemic acute kidney injury

Han SJ, Lee HT

Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem without effective therapy and is a significant and frequent cause of morbidity and mortality during...
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Allergy and Genetics

Shin DH

  • KMID: 2335099
  • J Korean Pediatr Soc.
  • 1994 Apr;37(4):439-451.
Allergy was originally defined in 1906 in 1906 by Clemens von Pirquet as 'altered reactivity' to denote the different reaction which on second exposure to and antigen due to the...
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Imidacloprid inhibits IgE-mediated RBL-2H3 cell degranulation and passive cutaneous anaphylaxis

Shi L, Zou L, Gao J, Xu H, Shi X, Chen H

BACKGROUND: Imidacloprid has been commonly used as a pesticide for crop protection and acts as nicotinic acetylcholine receptor agonists. Little information about the relationship between imidacloprid and allergy is available. OBJECTIVE:...
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Role of IgG, IgA, and IgE Antibodies in Nasal Polyp Tissue: Their Relationships with Eosinophilic Infiltration and Degranulation

Suh KS, Park HS, Nahm DH, Kim YK, Lee YM, Park K

To confirm local production of IgE, and evaluate role of immunoglobulins on eosinophil activation in nasal polyp (NP) tissue, we measured IgG, IgA, secretory IgA(sIgA), total (tIgE) and specific IgE...
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Allergen Frequencies on MAST CLA by Age Groups Using New Korean Panel

Park KI, Chun HS, Shin JW, Kim HS, Song KS

  • KMID: 2055402
  • J Clin Pathol Qual Control.
  • 1999 Jun;21(1):243-249.
BACKGROUND: Atopic allergy is a hypersensitive immunologic condition mediated by serum immunoglobulin E (IgE). IgE antibody binds to receptors on the surface of mast cells and basophilic leukocytes and subsequent...
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