- Study for the Antinociceptive Effect and Toxicity of Chronic Intrathecal Infusion of Cannabinoids in Rats
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Yoon MH, Bae HB, Choi JI, Bae CS, Kim SJ, Kim CM, Jeong ST, Kim KS, Jin WJ, Kim JP, Kim JS
- KMID: 2277975
- Korean J Pain.
- 2005 Dec;18(2):133-137.
- doi: 10.3344/kjp.2005.18.2.133
BACKGROUND: Cannabinoids have shown antinociceptive action. The aims of this study were to examine the effect of chronic infusion of a cannabinoids receptors agonist (WIN 55, 212-2) for thermal nociception... -
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- Pain medication and long QT syndrome
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Klivinyi C, Bornemann-Cimenti H
- KMID: 2400902
- Korean J Pain.
- 2018 Jan;31(1):3-9.
- doi: 10.3344/kjp.2018.31.1.3
Long QT syndrome is a cardiac repolarization disorder and is associated with an increased risk of torsades de pointes. The acquired form is most often attributable to administration of specific... -
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- Assessment of the Abuse Liability of Synthetic Cannabinoid Agonists JWH-030, JWH-175, and JWH-176
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Tampus R, Yoon SS, de la Pena JB, Botanas CJ, Kim HJ, Seo JW, Jeong EJ, Jang CG, Cheong JH
- KMID: 2380311
- Biomol Ther.
- 2015 Nov;23(6):590-596.
- doi: 10.4062/biomolther.2015.120
The emergence and use of synthetic cannabinoids have greatly increased in recent years. These substances are easily dispensed over the internet and on the streets. Some synthetic cannabinoids were shown... -
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- Neurotoxicity of Synthetic Cannabinoids JWH-081 and JWH-210
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Cha HJ, Seong YH, Song MJ, Jeong HS, Shin J, Yun J, Han K, Kim YH, Kang H, Kim HS
- KMID: 2380312
- Biomol Ther.
- 2015 Nov;23(6):597-603.
- doi: 10.4062/biomolther.2015.057
Synthetic cannabinoids JWH-018 and JWH-250 in 'herbal incense' also called 'spice' were first introduced in many countries. Numerous synthetic cannabinoids with similar chemical structures emerged simultaneously and suddenly. Currently there... -
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- Synthetic Cannabinoid-Induced Immunosuppression Augments Cerebellar Dysfunction in Tetanus-Toxin Treated Mice
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Yun J, Gu SM, Lee TH, Song YJ, Seong S, Kim YH, Cha HJ, Han KM, Shin J, Oh H, Jung K, Ahn C, Park HK, Kim HS
- KMID: 2378804
- Biomol Ther.
- 2017 May;25(3):266-271.
- doi: 10.4062/biomolther.2016.116
Synthetic cannabinoids are one of most abused new psychoactive substances. The recreational use of abused drug has aroused serious concerns about the consequences of these drugs on infection. However, the... -
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- The Psychiatric Effects of Cannabis
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Kim BS
- KMID: 2465998
- J Korean Soc Biol Ther Psychiatry.
- 2019 Oct;25(3):183-191.
- doi: 10.0000/jksbtp.2019.25.3.183
With the recent legalization of recreational cannabis in Canada and 11 states of the U.S., the interest surrounding cannabis use is increasing. However, many people and even clinicians in Korea... -
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- The pharmacological management of neuropathic pain
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Ko Y, Kim YH
- KMID: 2015657
- J Korean Med Assoc.
- 2012 Jun;55(6):582-592.
- doi: 10.5124/jkma.2012.55.6.582
Neuropathic pain has recently been defined as "pain arising as a direct consequence of a lesion or disease affecting the somatosensory system". Neuropathic pain is a debilitating chronic condition that... -
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- A Systematic Review of the Effectiveness of Medical Cannabis for Psychiatric, Movement and Neurodegenerative Disorders
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Lim K, See YM, Lee J
- KMID: 2396300
- Clin Psychopharmacol Neurosci.
- 2017 Nov;15(4):301-312.
- doi: 10.9758/cpn.2017.15.4.301
The discovery of endocannabinoid’s role within the central nervous system and its potential therapeutic benefits have brought forth rising interest in the use of cannabis for medical purposes. The present... -
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- Dependence Potential of the Synthetic Cannabinoids JWH-073, JWH-081, and JWH-210: In Vivo and In Vitro Approaches
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Cha HJ, Lee KW, Song MJ, Hyeon YJ, Hwang JY, Jang CG, Ahn JI, Jeon SH, Kim HU, Kim YH, Seong WK, Kang H, Yoo HS, Jeong HS
- KMID: 2170632
- Biomol Ther.
- 2014 Jul;22(4):363-369.
Synthetic cannabinoids (CBs) such as the JWH series have caused social problems concerning their abuse liability. Because the JWH series produces euphoric and hallucinogenic effects, they have been distributed illegally... -
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- Cannabinoid receptor agonist protects cultured dopaminergic neurons from the death by the proteasomal dysfunction
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Jeon P, Yang S, Jeong H, Kim H
- KMID: 1447423
- Anat Cell Biol.
- 2011 Jun;44(2):135-142.
- doi: 10.5115/acb.2011.44.2.135
Cannabinoids have been proposed to possess neuroprotective properties; though their mechanism of action remains contentious, they are posited to prevent neurodegenerative disorders, including Parkinson's disease, the pathogenesis of which has... -
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- SR144528 as Inverse Agonist of CB2 Cannabinoid Receptor
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Rhee MH, Kim SK
- KMID: 1095119
- J Vet Sci.
- 2002 Sep;3(3):179-184.
It is now well established that several G protein- coupled receptors can signal without agonist stimulation (constitutive receptors). Inverse agonists have been shown to inhibit the activity of such constitutive... -
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- Functional activity of the cannabinoid 1 receptor is not affected by opioid antagonists in the rat brain
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Lee H
- KMID: 1767337
- Korean J Anesthesiol.
- 2013 Mar;64(3):257-261.
- doi: 10.4097/kjae.2013.64.3.257
BACKGROUND: WIN55212-2 is a synthetic cannabinoid agonist and selective to cannabinoid 1 (CB1) receptors, which are distributed mainly in the central nervous system. Opioid receptors and CB1 receptors have several... -
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- Selective Cannabinoid Receptor-1 Agonists Regulate Mast Cell Activation in an Oxazolone-Induced Atopic Dermatitis Model
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Nam G, Jeong SK, Park BM, Lee SH, Kim HJ, Hong SP, Kim B, Kim BW
- KMID: 2429478
- Ann Dermatol.
- 2016 Feb;28(1):22-29.
- doi: 10.5021/ad.2016.28.1.22
BACKGROUND: Many inflammatory mediators, including various cytokines (e.g. interleukins and tumor necrosis factor [TNF]), inflammatory proteases, and histamine are released following mast cell activation. However, the endogenous modulators for mast... -
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- Functional Role of Serine Residues of Transmembrane Dopamin VII in Signal Transduction of CB2 Cannabinoid Receptor
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Rhee MH
- KMID: 1095120
- J Vet Sci.
- 2002 Sep;3(3):185-191.
Using site-directed mutagenesis technique, I have replaced serine 285 and serine 292 with the alanine, and assessed the binding of agonist and signaling such as the inhibition of adenylyl cyclase... -
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- A role for endocannabinoids in acute stress-induced suppression of the hypothalamic-pituitary-gonadal axis in male rats
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Karamikheirabad M, Behzadi G, Faghihi M, Raoofian R, Ejtemaei Mehr S, Zuure WA, Sadeghipour HR
- KMID: 2167493
- Clin Exp Reprod Med.
- 2013 Dec;40(4):155-162.
- doi: 10.5653/cerm.2013.40.4.155
OBJECTIVE: Stress is known to be an inhibitor of the reproductive hypothalamic-pituitary-gonadal (HPG) axis. However, the neural and molecular connections between stress and reproduction are not yet understood. It is... -
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- Fluoroscopic Characterization of Colonic Dysmotility Associated to Opioid and Cannabinoid Agonists in Conscious Rats
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DÃaz-Ruano S, López-Pérez AE, Girón R, Pérez-GarcÃa I, MartÃn-Fontelles MI, Abalo R
- KMID: 2449102
- J Neurogastroenterol Motil.
- 2019 Apr;25(2):300-315.
- doi: 10.5056/jnm18202
BACKGROUND/AIMS: Gastrointestinal adverse effects have a major impact on health and quality of life in analgesics users. Non-invasive methods to study gastrointestinal motility are of high interest. Fluoroscopy has been... -
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