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The Expression of Aldehyde Dehydrogenase Family in Breast Cancer

Qiu Y, Pu T, Li L, Cheng F, Lu C, Sun L, Teng X, Ye F, Bu H

  • KMID: 2353084
  • J Breast Cancer.
  • 2014 Mar;17(1):54-60.
PURPOSE: It is widely accepted that aldehyde dehydrogenase (ALDH) activity is a signature of breast cancer stem cells, and high activity has been reported to be associated with poor clinical...
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Efficacy and impact of PARPi monotherapy to subsequent platinum-based chemotherapy in BRCA1/2 mutant ovarian cancer patients with secondary platinum-sensitive relapse

Kun S, Ma Y, Bu H, Kong B

Objective The therapeutic effect of poly(ADP-ribose) polymerase inhibitors (PARPi) monotherapy compared with platinum-based chemotherapy, and the impact to subsequent platinum-based chemotherapy after PARPi resistance were inconclusive. Methods BRCA1/2 mutant ovarian cancer patients with...
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The Presence of EpCAM-/CD49f+ Cells in Breast Cancer Is Associated with a Poor Clinical Outcome

Ye F, Qiu Y, Li L, Yang L, Cheng F, Zhang H, Wei B, Zhang Z, Sun L, Bu H

PURPOSE: It is well established that breast cancer stem cells (BCSCs) play an essential role in tumor invasion for both local and distant metastasis. The aim of this study was...
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Sensory involvement in the SOD1-G93A mouse model of amyotrophic lateral sclerosis

Guo YS, Wu DX, Wu HR, Wu SY, Yang C, Li B, Bu H, Zhang YS, Li CY

A subset of patients of amyotrophic lateral sclerosis (ALS) present with mutation of Cu/Zn superoxide dismutase 1 (SOD1), and such mutants caused an ALS-like disorder when expressed in rodents. These...
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The role of botulinum toxin type A related axon transport in neuropathic pain induced by chronic constriction injury

Bu H, Jiao P, Fan X, Gao Y, Zhang L, Guo H

Background: The mechanism of peripheral axon transport in neuropathic pain is still unclear. Chemokine ligand 13 (CXCL13) and its receptor (C-X-C chemokine receptor type 5, CXCR5) as well as GABA...
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CD49f Can Act as a Biomarker for Local or Distant Recurrence in Breast Cancer

Ye F, Zhong X, Qiu Y, Yang L, Wei B, Zhang Z, Bu H

PURPOSE: Metastasis and local recurrence are the primary causes of treatment failure and patient death in breast cancer. The aim of this study was to validate a metastasis- and local...
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Screening of Recurrence Related MicroRNA in Ductal Carcinoma In Situ and Functional Study of MicroRNA-654-5p

Li S, Pu T, Xiao L, Gao H, Li L, Ye F, Liu Y, Bu H

PURPOSE: Ductal carcinoma in situ (DCIS) contributes to 20%–30% of newly diagnosed cases of breast cancer in China. Although the breast cancer-specific mortality of DCIS is extremely low, a small...
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