J Breast Cancer.  2017 Jun;20(2):142-149. 10.4048/jbc.2017.20.2.142.

CD49f Can Act as a Biomarker for Local or Distant Recurrence in Breast Cancer

Affiliations
  • 1Laboratory of Pathology, State Key Laboratory of Biotherapy, National Collaborative Innovation Center for Biotherapy, Chengdu, China.
  • 2Cancer Center, State Key Laboratory of Biotherapy, National Collaborative Innovation Center for Biotherapy, Chengdu, China.
  • 3Laboratory of Molecular Diagnosis of Cancer, State Key Laboratory of Biotherapy, National Collaborative Innovation Center for Biotherapy, Chengdu, China.
  • 4Department of Pathology, West China Hospital, Sichuan University, Chengdu, China. molecularpathology@hotmail.com

Abstract

PURPOSE
Metastasis and local recurrence are the primary causes of treatment failure and patient death in breast cancer. The aim of this study was to validate a metastasis- and local recurrenceassociated biomarker for prognostic evaluation and planning treatment strategies.
METHODS
Formalin-fixed, paraffin-embedded tissues from a cohort of 312 patients (all stage II and III) were used. The prevalence of CD49f⁺ cells in the patients' tumors was analyzed and correlated with clinical characteristics to determine its prognostic and clinical implications.
RESULTS
CD49f⁺ tumor cells were found in a minority of tumors, with 62.8% of the samples showing not a single cell of this subtype. In the clinical characteristics analysis, which were performed with t-tests, CD49f⁺ tumors were not associated with age, tumor size, World Health Organization grade, nodal status, human epidermal growth factor receptor 2 status, progesterone receptor status, or estrogen receptor status, although they were significantly associated with disease recurrence (distant metastasis or/and local recurrence). Univariate survival analysis using the Kaplan-Meier method showed that CD49f⁺ tumors were associated with markedly decreased disease-free survival (DFS); the same result was found using multivariate Cox analysis, even when only chemotherapy-treated patients were analyzed.
CONCLUSION
Our results indicated that breast tumors with CD49f⁺ cancer cells are associated with an increased risk for disease recurrence after initial surgery with poor clinical outcomes (decreased DFS). Therefore, as it requires testing for only one additional protein, adding CD49f testing to conventional surgical pathology is a strategy that has great potential for prognostic and treatment-guidance purposes.

Keyword

Breast neoplasms; Integrin alpha6; Metastasis; Neoplastic stem cells; Prognosis

MeSH Terms

Breast Neoplasms*
Breast*
Cohort Studies
Disease-Free Survival
Estrogens
Humans
Integrin alpha6
Methods
Neoplasm Metastasis
Neoplastic Stem Cells
Pathology, Surgical
Prevalence
Prognosis
Receptor, Epidermal Growth Factor
Receptors, Progesterone
Recurrence*
Treatment Failure
World Health Organization
Estrogens
Integrin alpha6
Receptor, Epidermal Growth Factor
Receptors, Progesterone
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