- Early and Late Changes of MMP-2 and MMP-9 in Bleomycin-Induced Pulmonary Fibrosis
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Kim JY, Choeng HC, Ahn C, Cho SH
- KMID: 1782970
- Yonsei Med J.
- 2009 Feb;50(1):68-77.
- doi: 10.3349/ymj.2009.50.1.68
PURPOSE: Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of pulmonary fibrosis. To understand the role of MMP-2 and MMP-9 in pulmonary fibrosis, we evaluated the sequential dynamic change... -
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- Airway Obstruction after Acute Ozone Exposure in BALB/c Mice Using Barometric Plethysmography
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Jang AS, Choi IS, Kim SW, Song BC, Yeum CH, Jung JY
- KMID: 759627
- Korean J Intern Med.
- 2003 Mar;18(1):1-5.
BACKGROUND: Airway responsiveness after acute inhalation of ozone is related to the concentration and duration of ozone exposure. Using barometric whole-body plethysmography and increase in enhanced pause (Penh) as an... -
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- Potential use of an anticancer drug gefinitib, an EGFR inhibitor, on allergic airway inflammation
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Hur GY, Lee SY, Lee SH, Kim SJ, Lee KJ, Jung JY, Lee EJ, Kang EH, Jung KH, Lee SY, Kim JH, Shin C, Shim JJ, In KH, Kang KH, Yoo SH
- KMID: 1047088
- Exp Mol Med.
- 2007 Jun;39(3):367-375.
The EGFR plays an essential role in goblet cell hyperplasia and mucus hypersecretion. EGFR has an intrinsic tyrosine kinase activity that, when activated, induces the production of MUC5AC through the... -
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- TACI:Fc scavenging B cell activating factor (BAFF) alleviates ovalbumin-induced bronchial asthma in mice
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Moon EY, Ryu SK
- KMID: 1047085
- Exp Mol Med.
- 2007 Jun;39(3):343-352.
Asthma was induced by the sensitization and challenge with ovalbumin (OVA) in mice. B-cell activating factor (BAFF) plays a role in mature B cell generation and maintenance. Here, we investigated... -
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- Expression of Semaphorin 3A and Neuropilin 1 in Asthma
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Shim EJ, Chun E, Kang HR, Cho SH, Min KU, Park HW
- KMID: 1777678
- J Korean Med Sci.
- 2013 Oct;28(10):1435-1442.
- doi: 10.3346/jkms.2013.28.10.1435
Neuropilin 1 (NP1) is a part of essential receptor complexes mediating both semaphorin3A (SEMA3A) and vascular endothelial growth factor (VEGF) which is one of important mediators involved in the pathogenesis... -
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- Effect of bosentan on the production of proinflammatory cytokines in a rat model of emphysema
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Gamze K, Mehmet HM, Deveci F, Turgut T, ilhan F, Ozercan I
- KMID: 1090964
- Exp Mol Med.
- 2007 Oct;39(5):614-620.
Endothelin (ET) receptor antagonists have been developed to produce a reduction of ET related effects in various diseases, as well as in animal models of airway inflammation. We aimed to... -
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- Silencing IL-23 expression by a small hairpin RNA protects against asthma in mice
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Li Y, Sun M, Cheng H, Li S, Liu L, Qiao H, Hua S, Lu J
- KMID: 1104389
- Exp Mol Med.
- 2011 Apr;43(4):197-204.
- doi: 10.3858/emm.2011.43.4.024
To determine the impact of IL-23 knockdown by RNA interference on the development and severity of ovalbumin (OVA)-induced asthmatic inflammation, and the potential mechanisms in mice, the IL-23-specific RNAi-expressing pSRZsi-IL-23p19... -
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- Change of connexin 37 in allergen-induced airway inflammation
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Park SJ, Lee KS, Kim SR, Min KH, Lee KY, Choe YH, Park SY, Hong SH, Lee YC
- KMID: 1090966
- Exp Mol Med.
- 2007 Oct;39(5):629-640.
Gap junction channels formed with connexins directly link to the cytoplasm of adjacent cells and have been implicated in intercellular signaling. Connexin 37 (Cx37) is expressed in the gas-exchange region... -
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- Regulation of pro-inflammatory responses by lipoxygenases via intracellular reactive oxygen species in vitro and in vivo
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Kim SY, Kim TB, Moon KA, Kim TJ, Shin D, Cho YS, Moon HB, Lee KY
- KMID: 1094126
- Exp Mol Med.
- 2008 Aug;40(4):461-476.
- doi: 10.3858/emm.2008.40.4.461
Reactive oxygen species (ROS) performs a pivotal function as a signaling mediator in receptor-mediated signaling. However, the sources of ROS in this signaling have yet to be determined, but may... -
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