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The Antimydriatic Effect of Brimonidine 0.15% on the Dark-adapted Pupil in Dark Brown Irides

Rho SS, Yang HS, Lew HM, Ahn JH

  • KMID: 2337690
  • J Korean Ophthalmol Soc.
  • 2008 Oct;49(10):1649-1657.
PURPOSE: To analyze the effect of the daily use of brimonidine tartrate 0.15% on the dark-adapted pupil diameter in dark brown irides. METHODS: Twenty-five healthy volunteers administered brimonidine tartrate 0.15% to...
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Comparison of Allergy Prevalence between Brimonidine/Timolol Fixed Combination and 0.15% Brimonidine in Glaucoma Patients

Park EJ, Chun YS

PURPOSE: To compare the allergy prevalence and clinical manifestations of 0.2% brimonidine/0.5% timolol fixed combination (BTFC) and 0.15% brimonidine in Korean patients with glaucoma. METHODS: We retrospectively analyzed the medical records...
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Changes in the Lacrimal Excretory System Depending on the Administration Mode of Brimonidine Tartrate: Spray vs. Irrigation

Yang HS, Oh DE

PURPOSE: To investigate the effects of 0.15% brimonidine tartrate ophthalmic solution spray on the luminal changes in the nasolacrimal excretory system. METHODS: A prospective study was performed on 52 eyes in...
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The Efficacy of Brinzolamide 1%/Brimonidine 0.2% Fixed Combination in Normal Tension Glaucoma

Shin HU, Jin SW

PURPOSE: To evaluate the efficacy and safety of brinzolamide 1%/brimonidine 0.2% fixed combination (BBFC) in normal tension glaucoma (NTG) patients. METHODS: This prospective study included patients treated with brinzolamide 1% monotherapy,...
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Brimonidine 0.2% versus Apraclonidine 0.5% for Controlling Intraocular Pressure Elevation after Q-switched Nd:YAG Laser Posterior Capsulotomy

Jeon SL, Lee JY, Lee KW

  • KMID: 2206147
  • J Korean Ophthalmol Soc.
  • 2002 Sep;43(9):1670-1678.
PURPOSE: To compare the effectiveness of 0.2% brimonidine tartrate and that of 0.5% apraclonidine hydrochloride for controlling IOP elevation after Nd:YAG laser capsulotomy. METHODS: Thirty eyes were given with 0.2% brimonidine...
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Topical Brimonidine as an Effective Adjuvant to Local Anesthetics for Post Treatment Erythema and Pain Reduction

Kwon HJ, Kim JM, Jeong GJ, Lee SJ, Lee HW, Park KY, Seo SJ

BACKGROUND: There are few pharmacologic options to reduce laser-associated post treatment erythema and to extend topical anesthesia duration. To improve the tolerability of painful laser treatment, dermatologists should encourage development...
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Prophylactic Use of Brimonidine for Intraocular Pressure Elevation after Nd: YAG Laser Posterior Capsulotomy

Cha SC, Bae SB, Lim HS

  • KMID: 2205614
  • J Korean Ophthalmol Soc.
  • 1999 Oct;40(10):2866-2875.
The purpose of this study was to evaluate the incidence and magnitude of intraocular pressure [IOP] spike following Nd: YAG laser posterior capsulotomy [YAG capsulotomy] in after-cataract patients with versus...
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The Relationship between Allergic Conjunctivitis due to Brimonidine and Systemic Allergic Disease in Glaucoma Patients

Han J, Choi W, Lee WS, Bae HW, Kim CY, Seong GJ

PURPOSE: Several different topical eye drop medications are used to lower the intraocular pressure of glaucoma patients. Among them, 0.1% brimonidine tartrate is commonly used and accompanies allergic conjunctivitis as...
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The Antinociceptive and Antiallodynic Effects by Brimonidine, a Selective alpha2 Adrenergic Agonist

Park JY, Park JH, Hwang JH

BACKGROUND: Clonidine, an alpha2 adrenoceptor agonist, has been known to have antinociceptive and antiallodynic effects. The antinociceptive and antiallodynic effects of brimonidine, a new selective alpha2 agonist, have not...
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The Additive Effect of 0.2%Brimonidine[Alphagan]to Beta-Adrenergic Receptor Blockers in Patients with Open Angle Glaucoma

Jeong CW, Seong GJ

  • KMID: 2336919
  • J Korean Ophthalmol Soc.
  • 2000 Mar;41(3):731-736.
Effect and side effects of adding 0.2% brimonidine to beta blockers was studied in 44 eyes of 32 glaucoma patients with inadequately controlled intraocular pressure[IOP]with beta blockers alone. Routine eye...
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Prophylactic Effect of Brimonidine 0.15% on IOP Elevation After Intravitreal Triamcinolone Acetonide Injection

Lee MW, Kyung SE, Chang MH

PURPOSE: The purpose of this study was to investigate the prophylactic effect of brimonidine 0.15% on intraocular pressure (IOP) elevation and the risk factors for its elevation after intravitreal triamcinolone...
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Prophylactic Use of Brimonidine or Apraclonidine for Intraocular Pressure Elevation following Laser Iridotomy

Suh WJ, Cha SC

  • KMID: 2206056
  • J Korean Ophthalmol Soc.
  • 2002 May;43(5):830-836.
PURPOSE: The purpose of this study was to evaluate and compare the prophylactic effect of brimonidine 0.2% and apraclonidine 0.5% in preventing intraocular pressure(IOP) elevation in patients undergoing laser iridotomy. METHODS:...
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Short-term Effect of 0.2% Brimonidine(Alphagan) in Normal Koreans

Lee YS, Seong GJ

  • KMID: 2205484
  • J Korean Ophthalmol Soc.
  • 1999 Mar;40(3):765-771.
Brimonidine(Alphagan)is a relatively selective-adrenoceptor agonist that activates receptor in the ciliary body, which lowers intraoculat pressure by decreasing aqueous production and increasing uveoscleral outflow. We investigated the short-term intraocular pressure...
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A Case of Herpetic Simplex Keratitis after Application of 0.015% Tafluprost Eye Drops

Park HG, Choi S

  • KMID: 2338580
  • J Korean Ophthalmol Soc.
  • 2013 Dec;54(12):1950-1953.
PURPOSE: To report a single case of herpes simplex keratitis after application of 0.015% tafluprost eye drops. CASE SUMMARY: A 68-year-old male presented with left eye discomfort, epiphora, decreased visual acuity...
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Effect of Bimatoprost on the Permeability of Trabecular Meshwork Cell Monolayer

Chang B, Kim JW

PURPOSE: To investigate the effects of bimatoprost on the permeability of cultured human trabecular meshwork cells (HTMC) monolayer. METHODS: HTMCs were cultured until confluency in the inner Transwell chamber and then...
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Comparison of antiallodynic effect of intrathecal morphine, brimonidine and rilmenidine between neuritis and ligation injury induced neuropathic pain

Kim YK, Park JY, Hwang JH

BACKGROUND: Mechanical allodynia is generally resulted from nerve damage by direct injury or inflammation. Thus, this study was designed to compare the antiallodynic effect of morphine, brimonidine and rilmenidine in...
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The Effect of Brimonidine Premedication on the Sympathetic Nervous System during Ketamine Anesthesia in the Ratv

Hwang KS, Choi Y, Lee SY, Lee YS, Lee YK, Jun HJ, Park SE, Han SM

BACKGROUND: The use of ketamine as the sole anesthetic induces marked central sympathetic stimulation, causing an increase of heart rate and blood pressure. alpha2-receptor agonist has been demonstrated to attenuate...
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The Effect of Intradermal Norepinephrine on Allodynia in a Neuropathic Pain Rat Model

Hwang JH, Choi DK, Kang HJ, Kim YK, Park JY

BACKGROUND: A spinal nerve ligation (SNL) injury may produce a neuropathic pain syndrome that includes tactile allodynia. This pain state may be diminished by sympathectomy. Intradermal (I.D.) injection...
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Comparison of Two Combinations of Maximum Medical Therapy for Lowering Intraocular Pressure in Primary Open-angle Glaucoma

Wy S, Kim YK, Jeoung JW, Park KH, Ha A

PURPOSE: We sought to compare the efficacy as well as the safety of two maximum medical therapy combinations applied to lower the intraocular pressure (IOP) in different primary open-angle glaucoma...
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The Effect of alpha2 Adrenoceptors and Imidazoline Receptors on the Mechanical Allodynia in Rats with Nerve Ligation Injury

Hwang JH, Kim YK, Park JY, Jun HJ

BACKGROUND: Clonidine, an alpha2 adrenoceptor agonist, has been known to have an antiallodynic effect in many animal and human studies. Clonidine, however, acts on imidazoline receptors as well as...
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