J Korean Ophthalmol Soc.  2000 Mar;41(3):731-736.

The Additive Effect of 0.2%Brimonidine[Alphagan]to Beta-Adrenergic Receptor Blockers in Patients with Open Angle Glaucoma

• Jeong CW
• Seong GJ

Abstract

Effect and side effects of adding 0.2% brimonidine to beta blockers was studied in 44 eyes of 32 glaucoma patients with inadequately controlled intraocular pressure[IOP]with beta blockers alone. Routine eye examination and IOP measurement were performed before the additive therapy. 0.2% brimonidine eye drops were topically applied three times a day with previously used beta blockers. IOP was measured at 1 week, 1 month, and 3months after the combined therapy. Mean IOP was 17.2 +/-1.8 millimeters of mercury before combined therapy ;13.5 +/-1.6 millimeters of mercury after 1 week, 14.3 +/-2.5 millimeters of mercury after 1 month and 13.6 +/-2.3 millimeters of mercury after 3 months of therapy. Side effects of combined therapy were oral dryness[25.0%], ocular pain[9.4%], and blurring[6.3%]. These results indicate that adding 0.2%brimonidine in patients treated with beta blockers causes a further reduction of IOP that may prove to be clinically useful in glaucoma therapy.

Keyword

0.2% Brimonidine; Beta blockers; Glaucoma; IOP

MeSH Terms

Glaucoma
Glaucoma, Open-Angle*
Humans
Ophthalmic Solutions
Brimonidine Tartrate
Ophthalmic Solutions