- Immortalization of Primary Keratinocytes and Its Application to Skin Research
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Choi M, Lee C
- KMID: 2380286
- Biomol Ther.
- 2015 Sep;23(5):391-399.
- doi: 10.4062/biomolther.2015.038
As a major component of the epidermal tissue, a primary keratinocyte has served as an essential tool not only for the study of pathogenesis of skin-related diseases but also for... -
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- Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2 and the Inhibition of H+/K+-ATPase
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Hwang IY, Jeong CS
- KMID: 2380295
- Biomol Ther.
- 2015 Sep;23(5):458-464.
- doi: 10.4062/biomolther.2015.052
Sennoside A (erythro) and sennoside B (threo) are dianthrone glycosides and diastereomers. We investigated their abilities to prevent the gastric lesions associated with diseases, such as, gastritis and gastric ulcer.... -
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- Acetylshikonin Inhibits Human Pancreatic PANC-1 Cancer Cell Proliferation by Suppressing the NF-kappaB Activity
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Cho SC, Choi BY
- KMID: 2380291
- Biomol Ther.
- 2015 Sep;23(5):428-433.
- doi: 10.4062/biomolther.2015.102
Acetylshikonin, a natural naphthoquinone derivative compound, has been used for treatment of inflammation and cancer. In the present study, we have investigated whether acetylshikonin could regulate the NF-kappaB signaling pathway,... -
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- Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid
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Peng JF, Liu L, Guo CX, Liu SK, Chen XP, Huang LH, Xiang H, Huang ZJ, Yuan H, Yang GP
- KMID: 2380287
- Biomol Ther.
- 2015 Sep;23(5):400-406.
- doi: 10.4062/biomolther.2015.010
MicroRNAs (miRNAs) are a family of non-coding RNA that are able to adjust the expression of many proteins, including ATP-binding cassette transporter and organic cation transporter. We sought to evaluate... -
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- Chondroprotective Effects of Wogonin in Experimental Models of Osteoarthritis in vitro and in vivo
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Park JS, Lee HJ, Lee DY, Jo HS, Jeong JH, Kim DH, Nam DC, Lee CJ, Hwang SC
- KMID: 2380293
- Biomol Ther.
- 2015 Sep;23(5):442-448.
- doi: 10.4062/biomolther.2015.045
We evaluated the chondroprotective effects of wogonin by investigating its effects on the gene expression and production of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as... -
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- Paraquat Induces Apoptosis through a Mitochondria-Dependent Pathway in RAW264.7 Cells
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Jang YJ, Won JH, Back MJ, Fu Z, Jang JM, Ha HC, Hong S, Chang M, Kim DK
- KMID: 2380288
- Biomol Ther.
- 2015 Sep;23(5):407-413.
- doi: 10.4062/biomolther.2015.075
Paraquat dichloride (N,N-dimethyl-4-4'-bipiridinium, PQ) is an extremely toxic chemical that is widely used in herbicides. PQ generates reactive oxygen species (ROS) and causes multiple organ failure. In particular, PQ has... -
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- Fisetin Suppresses Macrophage-Mediated Inflammatory Responses by Blockade of Src and Syk
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Kim JH, Kim MY, Kim JH, Cho JY
- KMID: 2380289
- Biomol Ther.
- 2015 Sep;23(5):414-420.
- doi: 10.4062/biomolther.2015.036
Flavonoids, such as fisetin (3,7,3',4'-tetrahydroxyflavone), are plant secondary metabolites. It has been reported that fisetin is able to perform numerous pharmacological roles including anti-inflammatory, anti-microbial, and anti-cancer activities; however, the... -
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- Imperatorin Suppresses Degranulation and Eicosanoid Generation in Activated Bone Marrow-Derived Mast Cells
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Jeong KT, Lee E, Park NY, Kim SG, Park HH, Lee J, Lee YJ, Lee E
- KMID: 2380290
- Biomol Ther.
- 2015 Sep;23(5):421-427.
- doi: 10.4062/biomolther.2015.023
Imperatorin has been known to exert many biological functions including anti-inflammatory activity. In this study, we investigated the inhibitory effects of imperatorin on the production of inflammatory mediators in mouse... -
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- A New Histone Deacetylase Inhibitor, MHY219, Inhibits the Migration of Human Prostate Cancer Cells via HDAC1
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De U, Kundu S, Patra N, Ahn MY, Ahn JH, Son JY, Yoon JH, Moon HR, Lee BM, Kim HS
- KMID: 2380292
- Biomol Ther.
- 2015 Sep;23(5):434-441.
- doi: 10.4062/biomolther.2015.026
Histone deacetylase (HDAC) inhibitors are considered novel agents for cancer chemotherapy. We previously investigated MHY219, a new HDAC inhibitor, and its potent anticancer activity in human prostate cancer cells. In... -
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- Sedative-Hypnotic and Receptor Binding Studies of Fermented Marine Organisms
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Joung HY, Kang YM, Lee BJ, Chung SY, Kim KS, Shim I
- KMID: 2380298
- Biomol Ther.
- 2015 Sep;23(5):479-485.
- doi: 10.4062/biomolther.2014.122
This study was performed to investigate the sedative-hypnotic activity of gamma-aminobutyric acid (GABA)-enriched fermented marine organisms (FMO), including sea tangle (FST) and oyster (FO) by Lactobacillus brevis BJ20 (L. brevis... -
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- Anti-Oxidative Effect of Myrtenal in Prevention and Treatment of Colon Cancer Induced by 1, 2-Dimethyl Hydrazine (DMH) in Experimental Animals
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Lokeshkumar B, Sathishkumar V, Nandakumar N, Rengarajan T, Madankumar A, Balasubramanian MP
- KMID: 2380297
- Biomol Ther.
- 2015 Sep;23(5):471-478.
- doi: 10.4062/biomolther.2015.039
Colon cancer is considered as the precarious forms of cancer in many developed countries, with few to no symptoms; the tumor is often diagnosed in the later stages of cancer.... -
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- Antiviral Activity of Chrysin Derivatives against Coxsackievirus B3 in vitro and in vivo
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Song JH, Kwon BE, Jang H, Kang H, Cho S, Park K, Ko HJ, Kim H
- KMID: 2380296
- Biomol Ther.
- 2015 Sep;23(5):465-470.
- doi: 10.4062/biomolther.2015.095
Chrysin is a 5,7-dihydroxyflavone and was recently shown to potently inhibit enterovirus 71 (EV71) by suppressing viral 3C protease (3Cpro) activity. In the current study, we investigated whether chrysin also... -
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- Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay
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Kim YH, Bae YJ, Kim HS, Cha HJ, Yun JS, Shin JS, Seong WK, Lee YM, Han KM
- KMID: 2380299
- Biomol Ther.
- 2015 Sep;23(5):486-492.
- doi: 10.4062/biomolther.2015.041
Drug metabolism mostly occurs in the liver. Cytochrome P450 (CYP) is a drug-metabolizing enzyme that is responsible for many important drug metabolism reactions. Recently, the US FDA and EU EMA... -
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- A Dunnione Compound MB12662 Improves Cisplatin-Induced Tissue Injury and Emesis
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Park D, Jo IG, Jang JY, Kwak TH, Yoo SK, Jeon JH, Choi EK, Joo SS, Kim O, Kim YB
- KMID: 2380294
- Biomol Ther.
- 2015 Sep;23(5):449-457.
- doi: 10.4062/biomolther.2015.034
The present study was aimed to investigate the effects of MB12662, a synthetic dunnione compound, on cisplatin-induced vomiting reflexes and intestinal, renal, immune system, and hematopoietic toxicities in ferrets and... -
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