- Keratinocytic Vascular Endothelial Growth Factor as a Novel Biomarker for Pathological Skin Condition
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Bae ON, Noh M, Chun YJ, Jeong TC
- KMID: 2380357
- Biomol Ther.
- 2015 Jan;23(1):12-18.
- doi: 10.4062/biomolther.2014.102
Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in... -
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- Promising Pharmacological Directions in the World of Lysophosphatidic Acid Signaling
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Stoddard N, Chun J
- KMID: 2380356
- Biomol Ther.
- 2015 Jan;23(1):1-11.
- doi: 10.4062/biomolther.2014.109
Lysophosphatidic acid (LPA) is a signaling lipid that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. These receptors initiate signaling cascades relevant to development, maintenance, and healing processes... -
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- Atractylochromene Is a Repressor of Wnt/beta-Catenin Signaling in Colon Cancer Cells
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Shim AR, Dong GZ, Lee HJ, Ryu JH
- KMID: 2380359
- Biomol Ther.
- 2015 Jan;23(1):26-30.
- doi: 10.4062/biomolther.2014.095
Wnt/beta-catenin signaling pathway was mutated in about 90% of the sporadic and hereditary colorectal cancers. The abnormally activated beta-catenin increases the cancer cell proliferation, differentiation and metastasis through increasing the... -
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- Thymosin Beta-4, Actin-Sequestering Protein Regulates Vascular Endothelial Growth Factor Expression via Hypoxia-Inducible Nitric Oxide Production in HeLa Cervical Cancer Cells
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Ryu YK, Lee JW, Moon EY
- KMID: 2380358
- Biomol Ther.
- 2015 Jan;23(1):19-25.
- doi: 10.4062/biomolther.2014.101
Vascular endothelial growth factor (VEGF) is an important regulator of neovascularization. Hypoxia inducible nitric oxide (NO) enhanced the expression of VEGF and thymosin beta-4 (Tbeta4), actin sequestering protein. Here, we... -
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- Effect of Cordycepin-Enriched WIB801C from Cordyceps militaris Suppressing Fibrinogen Binding to Glycoprotein IIb/IIIa
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Lee DH, Kim HH, Lim DH, Kim JL, Park HJ
- KMID: 2380364
- Biomol Ther.
- 2015 Jan;23(1):60-70.
- doi: 10.4062/biomolther.2014.086
In this study, we investigated the effects of cordycepin-enriched (CE)-WIB801C, a n-butanol extract of Cordyceps militaris-hypha on collagen-stimulated platelet aggregation. CE-WIB801C dose dependently inhibited collagen-induced platelet aggregation, and had a... -
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- Ciglitazone, a Peroxisome Proliferator-Activated Receptor Gamma Ligand, Inhibits Proliferation and Differentiation of Th17 Cells
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Kim DH, Ihn HJ, Moon C, Oh SS, Park S, Kim S, Lee KW, Kim KD
- KMID: 2380365
- Biomol Ther.
- 2015 Jan;23(1):71-76.
- doi: 10.4062/biomolther.2014.042
Peroxisome proliferator-activated receptor gamma (PPARgamma) was identified as a cell-intrinsic regulator of Th17 cell differentiation. Th17 cells have been associated with several autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE), inflammatory... -
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- 7alpha-Hydroxycholesterol Elicits TLR6-Mediated Expression of IL-23 in Monocytic Cells
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Seo HC, Kim SM, Eo SK, Rhim BY, Kim K
- KMID: 2380367
- Biomol Ther.
- 2015 Jan;23(1):84-89.
- doi: 10.4062/biomolther.2014.067
We investigated the question of whether 7-oxygenated cholesterol derivatives could affect inflammatory and/or immune responses in atherosclerosis by examining their effects on expression of IL-23 in monocytic cells. 7alpha-Hydroxycholesterol (7alphaOHChol)... -
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- Anti-Inflammatory Effects of Water Chestnut Extract on Cytokine Responses via Nuclear Factor-kappaB-signaling Pathway
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Kim B, Kim JE, Choi BK, Kim HS
- KMID: 2380368
- Biomol Ther.
- 2015 Jan;23(1):90-97.
- doi: 10.4062/biomolther.2014.080
Water chestnut (Trapa japonica Flerov.) is an annual aquatic plant. In the present study, we showed that the treatment of water chestnut extracted with boiling water resulted in a significant... -
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- Therapeutic Effects of S-Petasin on Disease Models of Asthma and Peritonitis
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Lee KP, Kang S, Noh MS, Park SJ, Kim JM, Chung HY, Je NK, Lee YG, Choi YW, Im DS
- KMID: 2380362
- Biomol Ther.
- 2015 Jan;23(1):45-52.
- doi: 10.4062/biomolther.2014.069
To explore the anti-allergic and anti-inflammatory effects of extracts of Petasites genus, we studied the effects of s-petasin, a major sesquiterpene from Petasites formosanus (a butterbur species) on asthma and... -
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- Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans
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Lee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK
- KMID: 2380366
- Biomol Ther.
- 2015 Jan;23(1):77-83.
- doi: 10.4062/biomolther.2014.075
The seed of Vigna angularis has long been cultivated as a food or a folk medicine in East Asia. Genistein (4',5,7-trihydroxyisoflavone), a dietary phytoestrogen present in this plant, has been... -
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- Protective Effect of Liriodendrin Isolated from Kalopanax pictus against Gastric Injury
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Sohn YA, Hwang SA, Lee SY, Hwang IY, Kim SW, Kim SY, Moon A, Lee YS, Kim YH, Kang KJ, Jeong CS
- KMID: 2380363
- Biomol Ther.
- 2015 Jan;23(1):53-59.
- doi: 10.4062/biomolther.2014.103
In this study, we investigated the inhibitory activities on gastritis and gastric ulcer using liriodendrin which is a constituent isolated from Kalopanax pictus. To elucidate its abilities to prevent gastric... -
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- Tolfenamic Acid Suppresses Inflammatory Stimuli-Mediated Activation of NF-kappaB Signaling
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Shao HJ, Lou Z, Jeong JB, Kim KJ, Lee J, Lee SH
- KMID: 2380361
- Biomol Ther.
- 2015 Jan;23(1):39-44.
- doi: 10.4062/biomolther.2014.088
Tolfenamic acid (TA) is a traditional non-steroid anti-inflammatory drug (NSAID) and has been broadly used for the treatment of migraines. Nuclear factor kappa B (NF-kappaB) is a sequence-specific transcription factor... -
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- The Histone Deacetylase Inhibitor Trichostatin A Sensitizes Human Renal Carcinoma Cells to TRAIL-Induced Apoptosis through Down-Regulation of c-FLIP(L)
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Han MH, Park C, Kwon TK, Kim GY, Kim WJ, Hong SH, Yoo YH, Choi YH
- KMID: 2380360
- Biomol Ther.
- 2015 Jan;23(1):31-38.
- doi: 10.4062/biomolther.2014.092
Histone acetylation plays a critical role in the regulation of transcription by altering the structure of chromatin, and it may influence the resistance of some tumor cells to tumor necrosis... -
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