- The Heterochromatin-1 Phosphorylation Contributes to TPA-Induced AP-1 Expression
-
Choi WJ
- KMID: 2170624
- Biomol Ther.
- 2014 Jul;22(4):308-313.
Activator protein-1 (AP-1) is an inducible transcription factor that contributes to the generation of chronic inflammation in response to oxidative and electrophilic stress. Previous studies have demonstrated that the PI3K/Akt1... -
- CITED
-
- Close
- SHARE
-
- Close
- Genetically Engineered Mouse Models for Drug Development and Preclinical Trials
-
Lee H
- KMID: 2170618
- Biomol Ther.
- 2014 Jul;22(4):267-274.
Drug development and preclinical trials are challenging processes and more than 80% to 90% of drug candidates fail to gain approval from the United States Food and Drug Administration. Predictive... -
- CITED
-
- Close
- SHARE
-
- Close
- Silymarin Inhibits Cytokine-Stimulated Pancreatic Beta Cells by Blocking the ERK1/2 Pathway
-
Kim EJ, Kim J, Lee MY, Sudhanva M, Devakumar , Jeon YJ
- KMID: 2170620
- Biomol Ther.
- 2014 Jul;22(4):282-287.
We show that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibits cytokine mixture (CM: TNF-alpha, IFN-gamma, and IL-1beta)-induced production of nitric oxide (NO) in the pancreatic beta... -
- CITED
-
- Close
- SHARE
-
- Close
- Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS)
-
Choi YL, Park EJ, Kim E, Na DH, Shin YH
- KMID: 2170626
- Biomol Ther.
- 2014 Jul;22(4):321-327.
Collagen pentapeptide (Lys-Thr-Thr-Lys-Ser, KTTKS) and its palmitoylated derivative (pal-KTTKS) have received a great deal of attention as cosmeceutical ingredients for their anti-wrinkle effects. The objective of this study was to... -
- CITED
-
- Close
- SHARE
-
- Close
- Antitumor and Apoptosis Induction Effects of Paeonol on Mice Bearing EMT6 Breast Carcinoma
-
Ou Y, Li Q, Wang J, Li K, Zhou S
- KMID: 2170629
- Biomol Ther.
- 2014 Jul;22(4):341-346.
Paeonol is a major phenolic micromolecular component of Moutan cortex Radicis, a traditional Chinese Medicine. It has shown antitumor effects in previous studies; however, the underlying mechanisms remain unknown. This... -
- CITED
-
- Close
- SHARE
-
- Close
- Fucodiphlorethol G Purified from Ecklonia cava Suppresses Ultraviolet B Radiation-Induced Oxidative Stress and Cellular Damage
-
Kim KC, Piao MJ, Zheng J, Yao CW, Cha JW, Kumara MH, Han X, Kang HK, Lee NH, Hyun JW
- KMID: 2170623
- Biomol Ther.
- 2014 Jul;22(4):301-307.
Fucodiphlorethol G (6'-[2,4-dihydroxy-6-(2,4,6-trihydroxyphenoxy)phenoxy]biphenyl-2,2',4,4',6-pentol) is a compound purified from Ecklonia cava, a brown alga that is widely distributed offshore of Jeju Island. This study investigated the protective effects of fucodiphlorethol G... -
- CITED
-
- Close
- SHARE
-
- Close
- Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells
-
An D, Kim K, Kim J
- KMID: 2170631
- Biomol Ther.
- 2014 Jul;22(4):355-362.
We have developed a fully automated high throughput drug screening (HTDS) system based on the microfluidic cell culture array to perform combinational chemotherapy. This system has 64 individually addressable cell... -
- CITED
-
- Close
- SHARE
-
- Close
- Anti-Inflammatory and PPAR Transactivational Effects of Oleanane-Type Triterpenoid Saponins from the Roots of Pulsatilla koreana
-
Li W, Yan XT, Sun YN, Ngan TT, Shim SH, Kim YH
- KMID: 2170628
- Biomol Ther.
- 2014 Jul;22(4):334-340.
In this study, 23 oleanane-type triterpenoid saponins were isolated from a methanol extract of the roots of Pulsatilla koreana. The NF-kappaB inhibitory activity of the isolated compounds was measured in... -
- CITED
-
- Close
- SHARE
-
- Close
- Adipose-Derived Stem Cells Improve Efficacy of Melanocyte Transplantation in Animal Skin
-
Lim WS, Kim CH, Kim JY, Do BR, Kim EJ, Lee AY
- KMID: 2170627
- Biomol Ther.
- 2014 Jul;22(4):328-333.
Vitiligo is a pigmentary disorder induced by a loss of melanocytes. In addition to replacement of pure melanocytes, cocultures of melanocytes with keratinocytes have been used to improve the repigmentation... -
- CITED
-
- Close
- SHARE
-
- Close
- Pachymic Acid Enhances Pentobarbital-Induced Sleeping Behaviors via GABA(A)-ergic Systems in Mice
-
Shah VK, Choi JJ, Han JY, Lee MK, Hong JT, Oh KW
- KMID: 2170625
- Biomol Ther.
- 2014 Jul;22(4):314-320.
This study was investigated to know whether pachymic acid (PA), one of the predominant triterpenoids in Poria cocos (Hoelen) has the sedative-hypnotic effects, and underlying mechanisms are mediated via gamma-aminobutyric... -
- CITED
-
- Close
- SHARE
-
- Close
- Anti-Inflammatory Effect of Mangostenone F in Lipopolysaccharide-Stimulated RAW264.7 Macrophages by Suppressing NF-kappaB and MAPK Activation
-
Cho BO, Ryu HW, So Y, Lee CW, Jin CH, Yook HS, Jeong YW, Park JC, Jeong IY
- KMID: 2170621
- Biomol Ther.
- 2014 Jul;22(4):288-294.
Mangostenone F (MF) is a natural xanthone isolated from Garcinia mangostana. However, little is known about the biological activities of MF. This study was designed to investigate the anti-inflammatory effect... -
- CITED
-
- Close
- SHARE
-
- Close
- Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells
-
Kim HJ, Kim J, Kang KS, Lee KT, Yang HO
- KMID: 2170619
- Biomol Ther.
- 2014 Jul;22(4):275-281.
Autophagy is a series of catabolic process mediating the bulk degradation of intracellular proteins and organelles through formation of a double-membrane vesicle, known as an autophagosome, and fusing with lysosome.... -
- CITED
-
- Close
- SHARE
-
- Close
- Cytochalasin B Modulates Macrophage-Mediated Inflammatory Responses
-
Kim MY, Kim JH, Cho JY
- KMID: 2170622
- Biomol Ther.
- 2014 Jul;22(4):295-300.
The actin cytoskeleton plays an important role in macrophage-mediated inflammatory responses by modulating the activation of Src and subsequently inducing nuclear factor (NF)-kappaB translocation. In spite of its critical functions,... -
- CITED
-
- Close
- SHARE
-
- Close
- Dependence Potential of the Synthetic Cannabinoids JWH-073, JWH-081, and JWH-210: In Vivo and In Vitro Approaches
-
Cha HJ, Lee KW, Song MJ, Hyeon YJ, Hwang JY, Jang CG, Ahn JI, Jeon SH, Kim HU, Kim YH, Seong WK, Kang H, Yoo HS, Jeong HS
- KMID: 2170632
- Biomol Ther.
- 2014 Jul;22(4):363-369.
Synthetic cannabinoids (CBs) such as the JWH series have caused social problems concerning their abuse liability. Because the JWH series produces euphoric and hallucinogenic effects, they have been distributed illegally... -
- CITED
-
- Close
- SHARE
-
- Close
- Selective Estrogen Receptor Modulation by Larrea nitida on MCF-7 Cell Proliferation and Immature Rat Uterus
-
Ahn HN, Jeong SY, Bae GU, Chang M, Zhang D, Liu X, Pei Y, Chin YW, Lee J, Oh SR, Song YS
- KMID: 2170630
- Biomol Ther.
- 2014 Jul;22(4):347-354.
Larrea nitida is a plant that belongs to the Zygophyllaceae family and is widely used in South America to treat inflammatory diseases, tumors and menstrual pain. However, its pharmacological activity... -
- CITED
-
- Close
- SHARE
-
- Close
