- Targeting the Transforming Growth Factor-beta Signaling in Cancer Therapy
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Sheen YY, Kim MJ, Park SA, Park SY, Nam JS
- KMID: 2048301
- Biomol Ther.
- 2013 Sep;21(5):323-331.
TGF-beta pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-beta (TGF-beta) signaling pathway has the dual role in both tumor suppression and tumor promotion. To... -
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- Glutathione Depletion by L-Buthionine-S,R-Sulfoximine Induces Apoptosis of Cardiomyocytes through Activation of PKC-delta
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Kim YA, Kim MY, Jung YS
- KMID: 2048306
- Biomol Ther.
- 2013 Sep;21(5):358-363.
In the present study, we investigated the effect of intracellular glutathione (GSH) depletion in heart-derived H9c2 cells and its mechanism. L-buthionine-S,R-sulfoximine (BSO) induced the depletion of cellular GSH, and BSO-induced... -
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- Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin
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Kim B, Lee JY, Lee HY, Nam KY, Park J, Lee SM, Kim JE, Lee JD, Hwang JS
- KMID: 2048304
- Biomol Ther.
- 2013 Sep;21(5):343-348.
We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug... -
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- 6'-O-Galloylpaeoniflorin Protects Human Keratinocytes Against Oxidative Stress-Induced Cell Damage
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Yao CW, Piao MJ, Kim KC, Zheng J, Cha JW, Hyun JW
- KMID: 2048305
- Biomol Ther.
- 2013 Sep;21(5):349-357.
6'-O-galloylpaeoniflorin (GPF) is a galloylated derivate of paeoniflorin and a key chemical constituent of the peony root, a perennial flowering plant that is widely used as an herbal medicine in... -
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- Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition
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Byun HJ, Kang KJ, Park MK, Lee HJ, Kang JH, Lee EJ, Kim YR, Kim HJ, Kim YW, Jung KC, Kim SY, Lee CH
- KMID: 2048303
- Biomol Ther.
- 2013 Sep;21(5):338-342.
Sphingosylphosphorylcholine (SPC) is significantly increased in the malicious ascites of tumor patients and induces perinuclear reorganization of keratin 8 (K8) filaments in PANC-1 cells. The reorganization contributes to the viscoelasticity... -
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- Resveratrol Inhibits Nitric Oxide-Induced Apoptosis via the NF-Kappa B Pathway in Rabbit Articular Chondrocytes
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Eo SH, Cho H, Kim SJ
- KMID: 2048307
- Biomol Ther.
- 2013 Sep;21(5):364-370.
Resveratrol (trans-3,4'-trihydroxystillbene), a naturally occurring polyphenolic antioxidant found in grapes and red wine, elicits diverse biochemical responses and demonstrates anti-aging, anti-inflammatory, and anti-proliferative effects in several cell types. Previously, resveratrol... -
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- Antinociceptive, Immunomodulatory and Antipyretic Activity of Nymphayol Isolated from Nymphaea stellata (Willd.) Flowers
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Pandurangan SB, Paul AS, Savarimuthu I, Ali AA
- KMID: 2048310
- Biomol Ther.
- 2013 Sep;21(5):391-397.
In the present study, we aimed to analyze the antinociceptive, immunomodulatory and antipyretic activities of nymphayol were investigated in wistar rats and mice. Antinociceptive effect was evaluated by acetic acid... -
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- Anticolitic Effect of the Rhizome Mixture of Anemarrhena asphodeloides and Coptidis chinensis (AC-mix) in Mice
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Jang SE, Jeong JJ, Hyam SR, Han MJ, Kim DH
- KMID: 2048311
- Biomol Ther.
- 2013 Sep;21(5):398-404.
During a screening program to search the anticolitic herbal medicines, 80% ethanol extract of the rhizome of Anemarrhena asphodeloides (AA) was found to potently inhibit the expression of proinflammatory cytokines... -
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- Interrelation between Expression of ADAM 10 and MMP 9 and Synthesis of Peroxynitrite in Doxorubicin Induced Cardiomyopathy
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Lim SC
- KMID: 2048308
- Biomol Ther.
- 2013 Sep;21(5):371-380.
Doxorubicin is still main drug in chemotherapy with limitation of use due to adverse drug reaction. Increased oxidative stress and alteration of nitric oxide control have been involved in cardiotoxicity... -
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- Ginsenoside Rg3 Alleviates Lipopolysaccharide-Induced Learning and Memory Impairments by Anti-Inflammatory Activity in Rats
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Lee B, Sur B, Park J, Kim SH, Kwon S, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2048309
- Biomol Ther.
- 2013 Sep;21(5):381-390.
The purpose of this study was to examine whether ginsenoside Rg3 (GRg3) could improve learning and memory impairments and inflammatory reactions induced by injecting lipopolysaccharide (LPS) into the brains of... -
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- Kalopanaxsaponin A Exerts Anti-Inflammatory Effects in Lipopolysaccharide-Stimulated Microglia via Inhibition of JNK and NF-kappaB/AP-1 Pathways
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Jeong YH, Hyun JW, Kim Van Le T, Kim DH, Kim HS
- KMID: 2048302
- Biomol Ther.
- 2013 Sep;21(5):332-337.
Microglial activation plays an important role in the development and progression of various neurological disorders such as cerebral ischemia, multiple sclerosis, and Alzheimer's disease. Thus, controlling microglial activation can serve... -
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- Effect of Codonopsis lanceolata with Steamed and Fermented Process on Scopolamine-Induced Memory Impairment in Mice
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Weon JB, Yun BR, Lee J, Eom MR, Ko HJ, Kim JS, Lee HY, Park DS, Chung HC, Chung JY, Ma CJ
- KMID: 2048312
- Biomol Ther.
- 2013 Sep;21(5):405-410.
Codonopsis lanceolata (Campanulaceae) traditionally have been used as a tonic and to treat patients with lung abscesses. Recently, it was proposed that the extract and some compounds isolated from C.... -
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