- Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas
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Lee H
- KMID: 1093618
- Exp Mol Med.
- 2003 Oct;35(5):448-453.
Breast cancer susceptibility gene, BRCA2, is a tumor suppressor and individuals who inherit one defected copy of BRCA2 allele experience early onset breast cancer or ovarian cancer accompanied by the... -
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- Novel Germline Mutations of BRCA1 and BRCA2 in Korean Familial Breast Cancer Patients
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Kim HN, Shin MH, Lee R, Park MH, Kweon SS
- KMID: 2447211
- Chonnam Med J.
- 2019 May;55(2):99-103.
- doi: 10.4068/cmj.2019.55.2.99
Breast cancer is the second most common cancer in Korean women. Germline mutations in the BRCA1 and BRCA2 genes cause hereditary breast cancer and are detected in 15–20% of hereditary... -
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- Clinical significance of variants of unknown significances in BRCA genes
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Choi MC
- KMID: 2450245
- J Gynecol Oncol.
- 2019 Jul;30(4):e80.
- doi: 10.3802/jgo.2019.30.e80
No abstract available. -
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- Comparison of Targeted Next-Generation and Sanger Sequencing for the BRCA1 and BRCA2 Mutation Screening
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Park J, Jang W, Chae H, Kim Y, Chi HY, Kim M
- KMID: 2373527
- Ann Lab Med.
- 2016 Mar;36(2):197-201.
- doi: 10.3343/alm.2016.36.2.197
No abstract available. -
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- Development of thymic lymphomas in mice disrupted of Brca2 allele in the thymus
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Park PG, Lee H
- KMID: 756336
- Exp Mol Med.
- 2008 Jun;40(3):339-344.
- doi: 10.3858/emm.2008.40.3.339
Germ-line mutations in BRCA2 predispose to early-onset cancer. Homozygous mutant mouse, which has Brca2 truncated in exon 11 exhibit paradoxic occurrence of growth retardation and development of thymic lymphomas. However,... -
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- The Novel Pathogenic Mutation c.849dupT in BRCA2 Contributes to the Nonsense-Mediated mRNA Decay of BRCA2 in Familial Breast Cancer
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Li S, Ma J, Hu C, Zhang X, Xiao D, Hao L, Xia W, Yang J, Hu L, Liu X, Dong M, Ma D, Liu R
- KMID: 2421374
- J Breast Cancer.
- 2018 Sep;21(3):330-333.
- doi: 10.4048/jbc.2018.21.e33
In this study, we used next-generation sequencing methods to screen 300 individuals for BRCA1 and BRCA2. A novel mutation (c.849dupT) in BRCA2 was identified in a female patient and her... -
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- Conditional knockout of brca1/2 and p53 in mouse ovarian surface epithelium: Do they play a role in ovarian carcinogenesis?
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Kim KY, Park DW, Jeung EB, Choi KC
- KMID: 1072177
- J Vet Sci.
- 2010 Dec;11(4):291-297.
- doi: 10.4142/jvs.2010.11.4.291
Alterations of genes are known to be critical for the induction of tumorigenesis, but the mechanism of ovarian carcinogenesis is little understood and remains to be elucidated. In this study,... -
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- Young Israeli women with epithelial ovarian cancer: prevalence of BRCA mutations and clinical correlates
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Helpman L, Zidan O, Friedman E, Kalfon S, Perri T, Ben-Baruch G, Korach J
- KMID: 2413221
- J Gynecol Oncol.
- 2017 Sep;28(5):e61.
- doi: 10.3802/jgo.2017.28.e61
OBJECTIVE: The current study investigates disease patterns and outcomes in young Israeli epithelial ovarian cancer (EOC) patients and their association with BRCA mutation status. METHODS: Consecutive EOC patients diagnosed at or... -
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- Prevalence of BRCA1 and BRCA2 Mutations in Korean Breast Cancer Patients
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Ahn SH, Hwang UK, Kwak BS, Yoon HS, Ku BK, Kang HJ, Kim JS, Ko BK, Ko CD, Yoon KS, Cho DY, Kim JS, Son BH
- KMID: 1733488
- J Korean Med Sci.
- 2004 Apr;19(2):269-274.
- doi: 10.3346/jkms.2004.19.2.269
The incidence of breast cancer in Korea has been increasing in recent years, such that it is now the most common female cancer. Breast cancer in Korea is characterized by... -
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