- Individualization of drug therapy: an historical perspective
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Atkinson A
- KMID: 2050935
- Transl Clin Pharmacol.
- 2014 Dec;22(2):52-54.
- doi: 10.12793/tcp.2014.22.2.52
No abstract available. -
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- Intracerebroventricular drug administration
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Atkinson A
- KMID: 2390930
- Transl Clin Pharmacol.
- 2017 Sep;25(3):117-124.
- doi: 10.12793/tcp.2017.25.3.117
Among the various routes of drug administration, perhaps the least studied is intracerebroventricular (ICV) administration. This route has been shown to be particularly useful in administering to the central nervous... -
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- Physiological spaces and multicompartmental pharmacokinetic models
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Atkinson A
- KMID: 2351805
- Transl Clin Pharmacol.
- 2015 Dec;23(2):38-41.
- doi: 10.12793/tcp.2015.23.2.38
The idea of body compartments has its origins in physiology and antedates their use in both physiologically-based predictive pharmacokinetic models and in the simpler compartmental models used to analyze pharmacokinetic... -
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- The stable isotope method for determining absolute bioavailability
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Atkinson A
- KMID: 2386760
- Transl Clin Pharmacol.
- 2017 Jun;25(2):53-58.
- doi: 10.12793/tcp.2017.25.2.53
The bioavailability of a drug is usually assessed in healthy subjects. However, it is reasonable to expect that significant alterations in bioavailability may occur in actual patients with different diseases... -
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- Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research
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Atkinson A
- KMID: 2467964
- Transl Clin Pharmacol.
- 2019 Dec;27(4):119-122.
- doi: 10.12793/tcp.2019.27.4.119
In the conventional concept of translational research, investigations flow from the laboratory bench to the bedside. However, clinical research can also serve as the starting point for subsequent laboratory investigations... -
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- Pitfalls in the calculation of hemodialysis clearance and in the assessment of dialysis efficacy
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Atkinson A
- KMID: 2413835
- Transl Clin Pharmacol.
- 2016 Dec;24(4):153-156.
- doi: 10.12793/tcp.2016.24.4.153
The therapeutic technique of hemodialysis and the concept of clearance have both followed a long but instructive course of development. In addition, it recently has been shown that physiological changes... -
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- Augmented renal clearance
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Atkinson A
- KMID: 2420292
- Transl Clin Pharmacol.
- 2018 Sep;26(3):111-114.
- doi: 10.12793/tcp.2018.26.3.111
Adding to the complexity of caring for critically ill patients is the fact that many of them have a creatinine clearance that exceeds 130 mL/min/1.73 m². This phenomenon, termed augmented... -
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