- Darapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, Reduces Rho Kinase Activity in Atherosclerosis
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Zhang J, Xu DL, Liu XB, Bi SJ, Zhao T, Sui SJ, Ji XP, Lu QH
- KMID: 2374035
- Yonsei Med J.
- 2016 Mar;57(2):321-327.
- doi: 10.3349/ymj.2016.57.2.321
PURPOSE: Increased lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and Rho kinase activity may be associated with atherosclerosis. The principal aim of this study was to examine whether darapladib (a selective Lp-PLA2... -
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- KR-31543 reduces the production of proinflammatory molecules in human endothelial cells and monocytes and attenuates atherosclerosis in mouse model
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Choi JH, Yoo JY, Kim SO, Yoo SE, Oh GT
- KMID: 1402317
- Exp Mol Med.
- 2012 Dec;44(12):733-739.
KR-31543, (2S, 3R, 4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro-2-dimethyoxymethyl-3-hydroxy-2-methyl-2H-1-benz opyran is a new neuroprotective agent for ischemia-reperfusion damage. It has also been reported that KR-31543 has protective effects on lipid peroxidation and H2O2-induced reactive... -
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- A Higher Burden of Small Low-density Lipoprotein Particles is Associated with Profound Changes in the Free Androgen Index in Male Adolescents
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Choi YJ, Choi SH, Kim HJ, Han SJ, Hwang JS, Chung YS, Lee KW, Cho HK, Kim DJ
- KMID: 1777884
- J Korean Med Sci.
- 2011 Apr;26(4):534-539.
- doi: 10.3346/jkms.2011.26.4.534
From a young age, males are at higher cardiovascular risk than females. Dyslipidemia, including a higher burden related to small low-density lipoproteins (LDL), plays an important role in precipitating atherosclerosis... -
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- Relation of Anti- to Pro-Inflammatory Cytokine Ratios with Acute Myocardial Infarction
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Biswas S, Ghoshal PK, Mandal SC, Mandal N
- KMID: 1785653
- Korean J Intern Med.
- 2010 Mar;25(1):44-50.
- doi: 10.3904/kjim.2010.25.1.44
BACKGROUND/AIMS: Acute myocardial infarction (AMI) is a leading cause of death. Inflammatory processes play an important role in atherosclerosis, which is intimately related to AMI. The aim of this study... -
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