Korean J Intern Med.  2010 Mar;25(1):44-50. 10.3904/kjim.2010.25.1.44.

Relation of Anti- to Pro-Inflammatory Cytokine Ratios with Acute Myocardial Infarction

• Biswas S
• Ghoshal PK
• Mandal SC
• Mandal N

• KMID: 1785653
• DOI: http://doi.org/10.3904/kjim.2010.25.1.44

Abstract

BACKGROUND/AIMS
Acute myocardial infarction (AMI) is a leading cause of death. Inflammatory processes play an important role in atherosclerosis, which is intimately related to AMI. The aim of this study was to investigate the association between anti-inflammatory and pro-inflammatory cytokines ratios and AMI.
METHODS
A total of 90 AMI patients and 90 age-and sex-matched controls were recruited in this study. Plasma cytokines and conventional risk factors were determined by standard methods.
RESULTS
Patients with AMI showed increased interleukin (IL)-6 and tumor necrosis factor-alpha levels and lower anti- to pro-inflammatory cytokine ratios as compared with controls. A multivariate logistic regression analysis revealed that IL-10 to IL-6 ratio was independently associated with the occurrence of AMI (odds ratio [OR], 5.39; 95% confidence interval [CI], 2.39 to 12.17; p < 0.0001). In contrast, IL-6 levels were no longer significant in the multivariate model (OR, 1.02; 95% CI, 0.932 to 1.12; p = 0.603). A receiver operating characteristic (ROC) curve analysis indicated that IL-6 levels and IL-10 to IL-6 ratios were a significant predictor of AMI (area under ROC curve, 0.892 and 0.851, respectively).
CONCLUSIONS
Our results suggest that the ratio of IL-10 to IL-6 is independently associated with AMI, and reduced levels of this ratio may favor the development of AMI.

Keyword

Myocardial infarction, acute; Cytokines, inflammatory; ROC curve

MeSH Terms

Adult
Atherosclerosis/blood/epidemiology/immunology
Female
Humans
Interleukin-10/*blood
Interleukin-6/*blood
Logistic Models
Male
Middle Aged
Multivariate Analysis
*Myocardial Infarction/blood/epidemiology/immunology
Predictive Value of Tests
ROC Curve
Risk Factors