- The Therapeutic Efficacy of Apigenin in a Murine Model of Scleroderma
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Moon SJ, Min JK
- KMID: 1438530
- J Rheum Dis.
- 2012 Oct;19(5):237-238.
- doi: 10.4078/jrd.2012.19.5.237
No abstract available. -
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- Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
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Sung B, Chung HY, Kim ND
- KMID: 2367558
- J Cancer Prev.
- 2016 Dec;21(4):216-226.
- doi: 10.15430/JCP.2016.21.4.216
Apigenin (4′,5,7-trihydroxyflavone) is a flavonoid commonly found in many fruits and vegetables such as parsley, chamomile, celery, and kumquats. In the last few decades, recognition of apigenin as a cancer... -
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- Apigenin-induced apoptosis in cervical cancer cell lines
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Oh EK, Kim HJ, Bae SM, Park MY, Kim YW, Kim TE, Ahn WS
- KMID: 1479866
- Korean J Obstet Gynecol.
- 2008 Aug;51(8):874-881.
OBJECTIVE: Apigenin is a widely distributed plant flavonoid and was proposed as a potent antitumor agent. In this study, we investigated the anticancer effects of apigenin on human cervical cancer... -
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- Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells
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Sikder MA, Lee HJ, Ryu J, Park SH, Kim JO, Hong JH, Seok JH, Lee CJ
- KMID: 2320493
- Tuberc Respir Dis.
- 2014 Mar;76(3):120-126.
BACKGROUND: We investigated whether wogonin and apigenin significantly affect the epidermal growth factor receptor (EGFR) signaling pathway involved in MUC5AC mucin gene expression, and production from cultured airway epithelial cells;... -
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- Apigenin Inhibits Tumor Necrosis Factor-alpha-Induced Production and Gene Expression of Mucin through Regulating Nuclear Factor-Kappa B Signaling Pathway in Airway Epithelial Cells
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Seo HS, Sikder MA, Lee HJ, Ryu J, Lee CJ
- KMID: 2170594
- Biomol Ther.
- 2014 Nov;22(6):525-531.
- doi: 10.4062/biomolther.2014.094
In the present study, we investigated whether apigenin significantly affects tumor necrosis factor-alpha (TNF-alpha)-induced production and gene expression of MUC5AC mucin in airway epithelial cells. Confluent NCI-H292 cells were pretreated... -
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- The Inhibitory Effect of Apigenin on the Agonist-Induced Regulation of Vascular Contractility via Calcium Desensitization-Related Pathways
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Je HD, Kim HD, La HO
- KMID: 2170648
- Biomol Ther.
- 2014 Mar;22(2):100-105.
Apigenin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of... -
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- Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes
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Park JS, Kim DK, Shin HD, Lee HJ, Jo HS, Jeong JH, Choi YL, Lee CJ, Hwang SC
- KMID: 2170528
- Biomol Ther.
- 2016 Mar;24(2):163-170.
- doi: 10.4062/biomolther.2015.217
We examined whether apigenin affects the gene expression, secretion and activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3 in... -
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- Effects of Apigenin on Glutamate-induced [Ca2+]i Increases in Cultured Rat Hippocampal Neurons
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Han JH, Kim KJ, Jang HJ, Jang JH, Kim MJ, Sung KW, Rhie DJ, Jo YH, Hahn SJ, Lee MY, Yoon SH
- KMID: 1486142
- Korean J Physiol Pharmacol.
- 2008 Apr;12(2):43-49.
- doi: 10.4196/kjpp.2008.12.2.43
Flavonoids have been shown to affect calcium signaling in neurons. However, there are no reports on the effect of apigenin on glutamate-induced calcium signaling in neurons. We investigated whether apigenin... -
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- Dietary Flavonoid Apigenin is not Effective in Preventing Development of a Bleomycin-Induced Murine Model of Scleroderma
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Jun JB, Kim JK, Na YI, Han H, Paik SS, Kim SH, Kim YH
- KMID: 2223072
- J Rheum Dis.
- 2012 Aug;19(4):206-211.
- doi: 10.4078/jrd.2012.19.4.206
OBJECTIVE: Systemic sclerosis is a connective tissue disease characterized by vasculopathy, excessive accumulation of extracellular matrix, and fibrosis of the skin and internal organs. The dietary flavonoid apigenin has been... -
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- Isolation and Quantitative Analysis of BACE1 Inhibitory Compounds from Cirsium maackii Flower
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Bhatarrai , Seong SH, Jung HA, Choi JS
- KMID: 2468066
- Nat Prod Sci.
- 2019 Dec;25(4):326-333.
- doi: 10.20307/nps.2019.25.4.326
The purpose of our study was to evaluate anti-AD potential of Cirsium maackii flowers. MeOH extract, CH2Cl2, EtOAc, and n-BuOH fraction of this flower notably inhibited BACE1 (ICâ‚…â‚€ = 76.47... -
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- The Effects of the 3-OH Group of Kaempferol on Interfollicular Epidermal Stem Cell Fate
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Chae JB, Choi HR, Shin JW, Na JI, Huh CH, Park KC
- KMID: 2428925
- Ann Dermatol.
- 2018 Dec;30(6):694-700.
- doi: 10.5021/ad.2018.30.6.694
BACKGROUND: Kaempferol (3,4′,5,7-tetrahydroxyflavone) is a flavonoid known to have a wide range of pharmacological activities. The 3-OH group in flavonoids has been reported to determine antioxidant activities. OBJECTIVE: We tested whether... -
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- Effects of Flavonoid Compounds on beta-amyloid-peptide-induced Neuronal Death in Cultured Mouse Cortical Neurons
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Choi SM, Kim BC, Cho YH, Choi KH, Chang J, Park MS, Kim MK, Cho KH, Kim JK
- KMID: 2172158
- Chonnam Med J.
- 2014 Aug;50(2):45-51.
- doi: 10.4068/cmj.2014.50.2.45
Excessive accumulation of beta-amyloid peptide (Abeta) is one of the major mechanisms responsible for neuronal death in Alzheimer's disease. Flavonoids, primarily antioxidants, are a group of polyphenolic compounds synthesized in... -
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- Apoptotic Effects of Genistein, Biochanin-A and Apigenin on LNCaP and PC-3 Cells by p21 through Transcriptional Inhibition of Polo-like Kinase-1
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Seo YJ, Kim BS, Chun SY, Park YK, Kang KS, Kwon TG
- KMID: 1123450
- J Korean Med Sci.
- 2011 Nov;26(11):1489-1494.
- doi: 10.3346/jkms.2011.26.11.1489
Natural isoflavones and flavones are important dietary factors for prostate cancer prevention. We investigated the molecular mechanism of these compounds (genistein, biochanin-A and apigenin) in PC-3 (hormone-independent/p53 mutant type) and... -
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- Protective Effect of Flavonoids on Lymphocyte DNA Damage Using Comet Assay
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Park YK, Jeon EJ, Kang MH
- KMID: 2269636
- Korean J Nutr.
- 2003 Mar;36(2):125-132.
The present study was attempted to investigate and compare the antioxidant potency of several well-know flavonoids, antioxidant vitamin and commercially available popular beverages. The antioxidant potency was assessed by the... -
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- Composition of Flavonoids and Antioxidative Activity from Juice of Jeju Native Citrus Fruits during Maturation
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Kim YD, Ko WJ, Koh KS, Jeon YJ, Kim SH
- KMID: 2264727
- Korean J Nutr.
- 2009 Apr;42(3):278-290.
- doi: 10.4163/kjn.2009.42.3.278
This study aims to evaluate the changes of flavonoid contents and antioxidants activity of Jeju native citrus fruits juice according to the harvest date. Flavonoids such as quercatagetin, narirutin, hesperidin... -
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- Effects of Scutellarin on MUC5AC Mucin Production Induced by Human Neutrophil Elastase or Interleukin 13 on Airway Epithelial Cells
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Jiang DP, Perelman J, Kolosov VP, Zhou XD
- KMID: 1785964
- J Korean Med Sci.
- 2011 Jun;26(6):778-784.
- doi: 10.3346/jkms.2011.26.6.778
Scutellarin is a flavonoid extracted from a traditional Chinese herb, Erigeron breviscapus. The present study investigated the effect of scutellarin on MUC5AC mucin production and the possible mechanism. Human bronchial... -
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