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Two Cases of Transfusion-related Acute Lung Injury Triggered by HLA and Anti-HLA Antibody Reaction

Lee JH, Kang ES, Kim DW

Transfusion-related acute lung injury (TRALI) is a serious adverse transfusion reaction that is presented as acute hypoxemia and non-cardiogenic pulmonary edema, which develops during or within 6 hr of transfusion....
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In vivo hepatitis B virus-neutralizing activity of an anti-HBsAg humanized antibody in chimpanzees

Kim SH, Oh HK, Ryu CJ, Park SY, Hong HJ

Previously, we constructed a humanized antibody (HuS10) that binds to the common a antigenic determinant on the S protein of HBV. In this study, we evaluated its HBV-neutralizing activity in...
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Gamma interferon modulates epidermal cell proliferation and mixed epidermal cell-lymphocyte reaction

Kim SY, Houh W

Gamma interferon (gamma-IFN), a lymphokine produced by activated T lymphocytes, has a variety of effects on target cell. It induces class II antigens of the major histocompatibility complex not...
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Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene

Kim MH, Kang SY, Lee WI

PURPOSE: The aim of this study is to investigate the molecular characteristics of occult hepatitis B virus (HBV) infection in ‘anti-HBc alone’ subjects. MATERIALS AND METHODS: Twenty-four patients with ‘anti-HBc alone’...
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Subdominant H60 antigen-specific CD8 T-cell response precedes dominant H4 antigen-specific response during the initial phase of allogenic skin graft rejection

Yoo KI, Jeon JY, Ryu SJ, Nam G, Youn H, Choi EY

In allogeneic transplantation, including the B6 anti-BALB.B settings, H60 and H4 are two representative dominant minor histocompatibility antigens that induce strong CD8 T-cell responses. With different distribution patterns, H60 expression...
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Clinical Relevance of Pretransplant HLA Class II Donor-specific Antibodies in Renal Transplantation Patients with Negative T-cell Cytotoxicity Crossmatches

Song EY, Lee YJ, Hyun J, Kim YS, Ahn C, Ha J, Kim SJ, Park MH

BACKGROUND: We evaluated the clinical relevance of pretransplant donor-specific HLA antibodies (DSA) in renal transplantation patients who had negative T-cell cytotoxicity crossmatches. METHODS: From 328 consecutive renal transplant recipients, we selected...
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Sensitization to and Challenge with Gliadin Induce Pancreatitis and Extrapancreatic Inflammation in HLA-DQ8 Mice: An Animal Model of Type 1 Autoimmune Pancreatitis

Moon SH, Kim J, Kim MY, Park DH, Song TJ, Kim SA, Lee SS, Seo DW, Lee SK, Kim MH

BACKGROUND/AIMS: The aim of this study was to establish a pathogenetic mechanism of pancreatitis in celiac disease and IgG4-related disease using gluten-sensitive human leukocyte antigen (HLA)-DQ8 transgenic mice. METHODS: Transgenic mice...
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The Clinical Significance of Antibody Screening Test Including Di(a+) Panel Cell in Asian-Mongoloid Populations

Park TS, Oh SH, Choi JC, Lee DD, Kim HH, Chang CL, Lee EY, Son HC

The Di(a) antigen is well known as one of the antigens with low incidence among Caucasians; however, it has been discovered with a relatively higher incidence among Mongoloid populations. Thus,...
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An Experience of the Use of Anti-HBc and Anti-HBs for Blood Donor Screening Tests at a Tertiary Hospital Blood Center in Korea

Lim YA, Yoon S

BACKGROUND: The aim of this study was to report the first experience of using tests of antibody to hepatitis B core antigen (anti-HBc) and antibody to hepatitis B surface antigen...
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Identification and characterization of allergens of Chironomus flaviplumus adults (Chironomidae, Diptera) in mice

Ree HI, Lee SH, Kim YK, Jeon S, Chang JK, Kim YS

Non-biting midges (Chironomidae, Diptera) are one of the largest insect families, which are distributed worldwidely and are found in nearly all types of inland waters. They are known to be...
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The significance of anti-HBc and occult hepatitis B virus infection in the occurrence of hepatocellular carcinoma in patients with HBsAg and anti-HCV negative alcoholic cirrhosis

Kim MJ, Kwon OS, Chung NS, Lee SY, Jung HS, Park DK, Ku YS, Kim YK, Kim YS, Kim JH

BACKGROUND/AIMS: Alcohol and the hepatitis B virus (HBV) exert synergistic effects in hepatocelluar carcinogenesis. We aimed to elucidate the clinical significance of the antibody to hepatitis B core antigen...
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The Inverse Association Between the Presence of Antibody to Hepatitis B Surface Antigen and Atopy in Young Adults

Koh YI, Choi IS, Park CH, Ahn JS, Ji SG

BACKGROUND: Some bacterial and viral infections may reduce the risk of atopy, and this is based on the concept of their ability to divert the immune system towards the Th1...
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Comparison of the Frequencies and Distributions of Unexpected Antibodies Based on Different Calculation Criteria

Kim SY, Kang JE, Song DY, Kim KH, Kim HH, Lee EY, Son HC

BACKGROUND: The frequencies and distributions of unexpected antibodies have been reported using two different criteria, based on either number of persons tested or number of tests performed. But there has...
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Change of Hepatitis B Virus DNA Status in Anti-HBc Positive Liver Graft

Kwon CH, Suh KS, Cho JY, Yi NJ, Jang JJ, Lee KU

  • KMID: 760646
  • Korean J Hepatol.
  • 2006 Jun;12(2):191-200.
BACKGROUND/AIMS: Many patients with positive anti-HBc, but negative HBsAg, are known to harbor occult HBV infection, which may transmit the virus through the graft in liver transplantation. We examined...
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An Evaluation of Platelet Transfusion Response Using HLA Crossmatch-compatible Donors in Patients with Platelet Refractoriness

Hyun J, Lim YM, Park KD, Han BY, Kim YH, Han KS, Park MH

BACKGROUND: Majority of immune-mediated platelet refractoriness is caused by HLA alloimmunization and can be effectively managed by HLA-matched platelet transfusions. However, HLA class I-typed large-sized donor registry has not been...
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